Potential role of amyloid-beta in the pathogenesis of age-related macular degeneration
Sep 27, 2005 - 1:20:38 AM
Age-related macular degeneration (AMD) is the main cause of blindness in patients over the age of 60. In these AMD patients, choroidal neovascularization (CNV) is the most common cause of visual loss. The earliest clinically visible abnormality in AMD are extracellular deposits, called drusen. However, it was unclear which component of drusen contributes to AMD.
Recent data demonstrated that amyloid-beta (Abeta) deposition was found in drusen from eyes with AMD.
In a paper appearing online on September 15 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Takeshi Yoshida and colleagues from the University of Tokyo show that Abeta contained in drusen plays an important role in the pathogenesis of AMD. These results suggest that approaches for clearing Abeta deposition might be an effective strategy against the development of AMD.
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