XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
 
 India
Search

Last Updated: Nov 18, 2006 - 12:32:53 PM

Dental Channel
subscribe to Dental newsletter

Latest Research : Dental

   DISCUSS   |   EMAIL   |   PRINT
PDT Kills Drug-Resistant Bacteria of oral cavity
Mar 10, 2006 - 9:17:00 PM, Reviewed by: Dr. Priya Saxena

Results showed that the photosensitizer accumulated in the samples within 15 minutes. Very low doses of light killed nearly all the S. mutans bacteria, reducing its concentration to less than 0.1 percent.

 
Photodynamic therapy may be an effective treatment for fungal infections and certain bacterial infections of the oral cavity, including some that are resistant to antibiotics, research from the University at Buffalo's School of Dental Medicine has shown.

Researchers found that the bacteria S. mutans, as well as fungal organisms of the genus Candida, cultured from HIV patients, were highly susceptible to killing with minimal doses of PDT, both in laboratory dishes and on biofilms grown on denture material.

Results of the research were presented today (March 10, 2006) at the International Association of Dental Research meeting in Orlando, Fla.

"The results of the studies so far, while not completed, may have important implications in the treatment of oral infectious diseases currently confounding the medical and dental community," said Thomas S. Mang, Ph.D., associate professor of oral and maxillofacial surgery and senior author on the study.

"PDT may provide an adjunct to current antibiotic treatment or an alternative where antibiotics no longer are working. This may be vital for patients undergoing cancer therapy, HIV patients who demonstrate resistance to antibiotics and the elderly with persistent oral infections."

Photodynamic therapy is based on the propensity of certain types of cells or organisms to absorb light-sensitive drugs. This selective retention allows researchers to direct a laser beam into the organism, which activates the drug and kills the organism but does not damage surrounding tissue.

PDT has been shown to be effective against certain types of cancer, particularly Kaposi's sarcoma, cancer of the esophagus and breast cancer that has metastasized to the chest wall. The drug Photofrin� has been approved by the FDA as a sensitizer for PDT in the treatment of early and late stage endobronchial and esophageal cancers, as well as high-grade abnormal tissues associated with Barrett's esophagus, a peptic ulcer of the lower esophagus caused by the presence of cells that normally stay in the stomach lining.

In the current research, after adding the light-sensitive drug Photofrin� to the cultured samples and biofilm, the samples were exposed to various intensities of light.

Results showed that the photosensitizer accumulated in the samples within 15 minutes. Very low doses of light killed nearly all the S. mutans bacteria, reducing its concentration to less than 0.1 percent.

PDT also demonstrated significant killing of three types of Candida: C. albicans, which causes thrush, and C. glabrata and C. krusei, in samples harvested from immunocompromised (HIV) patients.
 

- Results of the research were presented today (March 10, 2006) at the International Association of Dental Research meeting in Orlando, Fla.
 

www.buffalo.edu

 
Subscribe to Dental Newsletter
E-mail Address:

 

Additional researchers on the study from UB were Patricia Yen Bee Ng, biotechnology student; Maureen Donley, DDS., clinical associate professor of restorative dentistry, and Ernest Hausmann, D.M.D., Ph.D., professor emeritus of oral biology. Also, Alan Hutson, Ph.D., associate professor and chair of the Department of Biostatistics; Paul Bronson, research technician; Jean Wactowski-Wende, Ph.D., associate professor of social and preventive medicine, all from the UB School of Public Health and Health Professions.

Edward Rossomando, Ph.D., professor of biostructure function at the University of Connecticut, also contributed to the study.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.


Related Dental News

Common Antacids Could Help Keep Gingivitis at Bay
Tetracycline plus teeth equal gray smile
Periodontal bacteria may be linked to acute coronary syndrome (ACS)
Ultrasound may help regrow teeth
Effects of stress, depression and cortisol on periodontal disease
Roasted vegetables could cause dental erosion
Periodontal therapy may help diabetic patients improve sugar control
Archaea Identified As Possible Human Pathogen
Cimetidine Inhibits Gum Disease in Rabbits
Dentistry in vogue 9,000 years ago in Balochistan


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us