RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
  Brain Diseases
   Epilepsy
  Demyelinating Diseases
  Headache
  Memory
  Neurochemistry
  Neurodegenerative Diseases
  Regeneration
  Spinal Cord Diseases
  Stroke
  Taste
  Trigeminal Neuralgia
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Pediatrics Epilepsy Channel

subscribe to Epilepsy newsletter
Latest Research : Neurosciences : Brain Diseases : Epilepsy

   EMAIL   |   PRINT
Multiple-stage surgery brings hope for Tuberous Sclerosis with intractable seizures

May 6, 2006 - 6:50:00 PM , Reviewed by: Rashmi Yadav
“At some centers multiple-stage surgery would be considered aggressive, but we have established that this type of surgery is safe.”

 
[RxPG] Sadly, none of the treatments for epilepsy—anti-seizure medications, a procedure called vagus nerve stimulation, a special diet —could quell the electrical storms in the young boy’s brain. Caused by a rare genetic disease called tuberous sclerosis, the seizures began when he was only 2 months old. By the time he was 5, he was having more than 10 a day. The seizures left him with the developmental capabilities of a 1-year-old child.

Today the boy rarely experiences seizures and his development has improved dramatically thanks to a bold three-stage brain operation being performed at NYU Medical Center by pediatric neurosurgeon Howard Weiner, M.D., Associate Professor of Neurosurgery and Pediatrics at New York University School of Medicine.

This child’s case study is part of a report in the May issue of the journal Pediatrics that describes 25 children with tuberous sclerosis who have been operated on by Dr. Weiner over the last six years. It is the largest report of epilepsy surgery in young children with the disease by a single surgeon in the medical literature.

The youngest child was 7 months old, and the oldest 17. They initially were evaluated extensively by a team of physicians that included Dr. Weiner and Orrin Devinsky, M.D., Professor of Neurology, Neurosurgery, and Psychiatry and Director of NYU’s Comprehensive Epilepsy Center. The evaluation included an overnight stay in a special inpatient pediatric epilepsy unit at NYU’s Tisch Hospital, equipped with 24-hour electroencephalography (EEG) and video monitoring to correlate the children’s behavior with unusual brain activity.

After the evaluation revealed that seizures were affecting many areas of their brains, the team determined that the multi-stage operation would be necessary. Nearly all of the children underwent three separate brain operations over a 2-1/2 week period. Some of the operations lasted as long as nine hours. During the entire period the children remained in Tisch Hospital, where their parents could sleep next to them.

Two or more years after the operations, 17 of the 25 children were free of seizures or had only mild non-disabling attacks. Six children still experienced more severe non-disabling seizures but the number of such seizures was reduced by more than 90 percent. In two children the number was reduced by 50 percent to 90 percent. Despite the risks of brain surgery, Dr. Weiner and his colleagues report that the multiple surgeries did not cause serious infections or permanent damage to the brain.

“At some centers multiple-stage surgery would be considered aggressive, but we have established that this type of surgery is safe,” says Dr. Weiner. “Certainly this type of surgery should only be reserved for the toughest cases—children with tuberous sclerosis who are having uncontrolled seizures in association with developmental delay or even regression.”

Tuberous sclerosis produces tubers on many organs in the body, including the skin, kidneys, lungs, and eyes. In the brain, the hard calcified growths cause seizures. Mental retardation, autism, and other developmental problems can occur in as many as two-thirds of individuals with the disease, according to the National Institute of Neurological Disorders and Stroke. Children with tuberous sclerosis typically have more than two tubers but some may have up to 20 in their brain, says Dr. Weiner.

Many children with the disease aren’t usually considered candidates for brain surgery because it is difficult to identify which tubers are causing seizures using electroencephalography (EEG), which records electrical activity in the brain through electrodes placed on the scalp. The seizures in these children are spreading so quickly that by the time the electrodes pick up the abnormal nerve firings, it is no longer possible to determine where they originated. Other noninvasive imaging techniques cannot accurately pinpoint where seizures begin.

To overcome this problem, neurosurgeons place electrodes directly on the brain itself, which requires removing a portion of the bony cranium and cutting through the dura mater, the tough fibrous tissue covering the brain. The implanted grid of electrodes, attached to an EEG machine, is used to continuously monitor seizure activity over several days, providing a map for the surgeon to the location where the seizures arise. In the second operation, the surgeon removes the seizure-causing tissue in the brain.

Dr. Weiner takes the operation one step further. He places another set of electrodes in the brain after the second operation in order to locate any other areas that may be causing seizures. So children are again monitored with a grid of electrodes over a period of days, and then undergo a third operation to remove any tissue that still may be causing seizures.

Despite the promising results so far, Dr. Weiner says that it hasn’t yet been demonstrated that there is a “direct correlation between freedom from seizures and developmental normalcy.” However, he adds, “it is important to treat children as early as possible because persistent seizures are associated with a host of serious learning and developmental problems.”



Publication: The study appears in the May issue of the journal Pediatrics
On the web: http://www.med.nyu.edu/ 

Advertise in this space for $10 per month. Contact us today.


Related Epilepsy News
High frequency oscillation analysis on EEGs offers a new surgical approach to improve seizure control
Anti-epileptic drugs increase risk of fractures in patients above the age of fifty years
More research and attention needed for epilepsy
Recent - onset seizures affect white matter development
Ethosuximide - most effective treatment for childhood absence epilepsy
Studies focusing on early diagnosis and treatment of epilepsy with minimal side-effects
Sudden Unexpected Death In Epilepsy
Topiramate may increase the risk of birth defects
Glutamate- involved in blocking response to anti-epileptic medication
Responsive Neurostimulator System: An implantable device to treat epilepsy

Subscribe to Epilepsy Newsletter

Enter your email address:


 Additional information about the news article
The report in the journal Pediatrics is entitled “Epilepsy Surgery in Young Children with Tuberous Sclerosis: Results of a Novel Approach.” The authors are Dr. Weiner, Dr. Devinsky, Chad Carlson, M.D., Emily Ridgway, M.D., Charles M. Zaroff, Ph.D., Daniel Miles, M.D., and Josiane LaJoie, M.D.
 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)