USA
Update on Rare Multi-Drug Resistant HIV strain in New York City man
By New York City Department of Health and Mental Hygiene
Mar 31, 2005, 16:53

The New York City Department of Health and Mental Hygiene is continuing its investigation of a multi-drug-class resistant strain of HIV that appears to have rapidly progressed to AIDS in a New York City man. This is an update on the status of the investigation.

* The source of the New York City man's infection is still unknown and remains under investigation.

* Although the patient's strain of HIV is highly drug resistant, the patient is responding to treatment thus far that includes the two drugs to which his strain appears to be susceptible, as well as other drugs which may be effective.

* The extent to which this strain has spread remains under investigation. As of today, no other cases of multi-drug-class resistant, rapidly progressive HIV have been identified.

* We have reached most of the named contacts of the patient. Many were previously HIV-infected. Obtaining blood samples for resistance testing, and testing of these samples to determine the genetic relatedness of strains is continuing and may take weeks to months to complete.

* Laboratories have identified several patients whose strains may be related to this patient's strains. However, database matching and laboratory analysis of these strains is complex and we do not expect to have results of genetic analyses of these strains for weeks or months. No patients with identical strains have been identified.

* The Aaron Diamond AIDS Research Center recently presented findings from a study of a group of men who have sex with men who were tested for HIV between 1999 and 2004, which indicated that more than one quarter of those with recent infection have resistance to one or more drugs. Resistance to any 2 classes of antiretroviral drugs increased from 2.6% in 2000 to 9.4% in 2004.

In summary, there is good news and bad news , and there are many things that we still don't know .

The good news:

* The patient is responding to treatment thus far. This indicates that the strain, while difficult to treat, appears to be treatable at this point. However, the patient remains critically ill and must continue to be monitored closely.

* To date, no other patients have been identified with the same strain

* Through efforts of the Health Department, physicians, laboratories, and others, there is now a monitoring system in place to identify similar cases if they occur.

* The Health Department has learned from physicians that they are testing patients for this strain of HIV. This means that we have a better chance of identifying additional cases in the coming months and years if they occur.

* Community organizations and physicians report an increased discussion of the need for safer sex and HIV prevention

* The patient is responding to treatment thus far. This indicates that the strain, while difficult to treat, appears to be treatable at this point. However, the patient remains seriously ill and must continue to be monitored closely.

The bad news:

* Many of the patient's partners were anonymous and the Health Department will not be able to reach them. Therefore, they may not be tested for HIV and, if infected, may not be diagnosed for months or years.

* Investigation of the social network surrounding this case indicates that unsafe, anonymous sex along with the use of drugs including crystal methamphetamine remains common. Many of the patient's partners already knew they were HIV-positive, some for many years. Nevertheless, they had unsafe sex and used drugs. Many had a recent history of other sexually transmitted diseases, such as syphilis and gonorrhea.

* Many unsafe sexual encounters occurred in public sex venues and through Internet contacts.

What we don't know (a partial list)

* The precise time of this patient's infection, which occurred sometime between 4-20 months prior to his first positive HIV test.

* How many other people have similar strains of HIV
o Whether there have been additional patients with this strain who remain undiagnosed;
o Whether there will be such cases in the future.

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