The researchers show that activity of a protein called plasmin is an essential step in the early phase of blister formation in the mouse model. They further show that plasmin joins another protein, MMP-9, in a pathological signaling pathway during the early phase of disease.
By Journal of Clinical Investigation, [RxPG] Pemphigus is a skin blistering disease that causes separation of the layers of the skin, along with inflammation.
In a paper appearing in the April 1 issue of The Journal of Clinical Investigation, Zhi Liu and colleagues from the University of North Carolina use a mouse model of pemphigus to unravel the mechanisms of this disease.
The researchers show that activity of a protein called plasmin is an essential step in the early phase of blister formation in the mouse model. They further show that plasmin joins another protein, MMP-9, in a pathological signaling pathway during the early phase of disease.
According to a related commentary by Kim Yancey of the Medical College of Wisconsin, these results "will facilitate the development of effective interventions that counteract the chronic morbidity and, at times, mortality" of skin blistering diseases.
Publication:
TITLE: Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
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TITLE: Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
AUTHOR CONTACT:
Zhi Liu
University of North Carolina, Chapel Hill, North Carolina, USA.
Phone: (919) 966-0785; Fax: (919) 966-3898; E-mail: [email protected]
View the PDF of this article at: https://www.the-jci.org/article.php?id=23977
ACCOMPANYING COMMENTARY:
TITLE: The pathophysiology of autoimmune blistering diseases
AUTHOR CONTACT:
Kim B. Yancey
Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Phone: (414) 456-4081; Fax: (414) 456-6518; E-mail: [email protected]
View the PDF of this article at: https://www.the-jci.org/article.php?id=24855
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