XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
  Asthma
  COPD
  Cystic Fibrosis
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Nov 17th, 2006 - 22:35:04

Respiratory Medicine Channel
subscribe to Respiratory Medicine newsletter

Latest Research : Respiratory Medicine

   DISCUSS   |   EMAIL   |   PRINT
A1 lets lungs breathe a sigh of relief
Apr 3, 2005, 13:11, Reviewed by: Dr.


The authors also show that high oxygen concentration stimulates A1, that A1 regulates death of cells in the lung, and that it plays a central role in the induction of other proteins that modulate programmed cell death. In mice lacking A1, the harmful effects of oxygen are intensified whereas overexpressing A1 decreases lung cell death in the presence of oxygen.


 
Patients with lung and heart disease are commonly given supplemental oxygen, however very high concentrations of oxygen administered for extended periods of time can trigger lung injury.

The mechanism underlying this lung injury has not been characterized. In a study appearing in the April 1 issue of The Journal of Clinical Investigation, Jack Elias and colleagues from Yale University demonstrate that a protein called A1 is a critical regulator in this type of lung injury.

The authors also show that high oxygen concentration stimulates A1, that A1 regulates death of cells in the lung, and that it plays a central role in the induction of other proteins that modulate programmed cell death. In mice lacking A1, the harmful effects of oxygen are intensified whereas overexpressing A1 decreases lung cell death in the presence of oxygen.

In an accompanying commentary, G.R.Scott Budinger and Jacob Sznajder writes that these studies will "influence future investigations into the molecular mechanisms by which these [A1] pathways become activated to contribute to�lung injury."
 

- TITLE: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxia acute lung injury
 

View the PDF of this article commentary

 
Subscribe to Respiratory Medicine Newsletter
E-mail Address:

 

TITLE: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxia acute lung injury

AUTHOR CONTACT:
Jack Elias
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone: (203) 785-4163; Fax: (203) 785-3826; E-mail: [email protected]

View the PDF of this article at:

ACCOMPANYING COMMENTARY:

TITLE: To live or die: a critical decision for the lung

AUTHOR CONTACT:
Jacob I. Sznajder
Northwestern University, Chicago, Illinois, USA.
Phone: (312) 908-8163; Fax: (312) 908-4650; E-mail: [email protected]

View the PDF of this article at: https://www.the-jci.org/article.php?id=24681


Related Respiratory Medicine News

Acute lung injury is prevented by FoxM1 protein
Six-minute walk test predicts mortality rates in patients with pulmonary fibrosis
A dog in home may worsen asthma in children
Cystic fibrosis-related diabetes is due to functional abnormalities in beta cells
COPD patients using beta-agonist inhalers are at risk
Beta-agonists linked with increased number of respiratory deaths -study shows
Beta-agonists more than double death rate in COPD patients
No evidence for inhaled corticosteroids efficacy in cystic fibrosis
Lung function test underused in patients with COPD
Wrinkles clue to risk of progressive lung disease (COPD)


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us