http://www.rxpgnews.com/ Medical News and Information Thu, 21 Aug 2008 02:00:28 PST en-us http://www.rxpgnews.com/huntingtonsdisease/Mayo-discovers-link-between-Huntington-s-and-abnormal-cholesterol-levels-in-brain_7119.shtml Huntington's Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington's disease affects the brain. The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington's protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain. Sun, 03 Dec 2006 15:10:30 PST http://www.rxpgnews.com/huntingtonsdisease/Mayo-discovers-link-between-Huntington-s-and-abnormal-cholesterol-levels-in-brain_7119.shtml http://www.rxpgnews.com/huntingtonsdisease/PARP1_inhibitors_can_protect_Huntington_s_disease__4743_4743.shtml Huntington's An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels. In the August issue of Chemistry & Biology, a research team from the MassGeneral Institute for Neurodegenerative Disease (MIND) describes their discovery of a novel inhibitor of Poly (ADP-ribose) polymerase (PARP1) and their findings that PARP1 inhibitors can protect HD-affected cells from damage in laboratory assays. Sun, 30 Jul 2006 02:41:00 PST http://www.rxpgnews.com/huntingtonsdisease/PARP1_inhibitors_can_protect_Huntington_s_disease__4743_4743.shtml http://www.rxpgnews.com/huntingtonsdisease/Gene_therapy_protects_neurons_in_Huntington_s_dise_4590_4590.shtml Huntington's Researchers at Rush University Medical Center, Chicago, and Ceregene Inc., San Diego, have successfully used gene therapy to preserve motor function and stop the anatomic, cellular changes that occur in the brains of mice with Huntington's disease (HD). This is the first study to demonstrate that, using this delivery method, symptom onset might be prevented in HD mice with this treatment. Fri, 30 Jun 2006 03:02:00 PST http://www.rxpgnews.com/huntingtonsdisease/Gene_therapy_protects_neurons_in_Huntington_s_dise_4590_4590.shtml http://www.rxpgnews.com/huntingtonsdisease/Huntingtin_cleavage_is_caused_by_caspase-6_4482_4482.shtml Huntington's Researchers at the University of British Columbia's Centre for Molecular Medicine and Therapeutics (CMMT) have provided ground-breaking evidence for a cure for Huntington disease in a mouse offering hope that this disease can be relieved in humans. Sat, 17 Jun 2006 20:10:00 PST http://www.rxpgnews.com/huntingtonsdisease/Huntingtin_cleavage_is_caused_by_caspase-6_4482_4482.shtml http://www.rxpgnews.com/huntingtonsdisease/Clioquinol_an_antibiotic_shows_new_promise_for_Hun_2365_2365.shtml Huntington's Clioquinol, an antibiotic that was banned for internal use in the United States in 1971 but is still used in topical applications, appears to block the genetic action of Huntington's disease in mice and in cell culture, according to a study reported by San Francisco VA Medical Center (SFVAMC) researchers. Mon, 12 Sep 2005 18:14:00 PST http://www.rxpgnews.com/huntingtonsdisease/Clioquinol_an_antibiotic_shows_new_promise_for_Hun_2365_2365.shtml http://www.rxpgnews.com/huntingtonsdisease/Potential_therapeutic_target_for_Huntington_s_dise_1007_1007.shtml Huntington's Researchers studying yeast cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. Thu, 07 Apr 2005 18:14:00 PST http://www.rxpgnews.com/huntingtonsdisease/Potential_therapeutic_target_for_Huntington_s_dise_1007_1007.shtml