Injectable Testosterone Undecanoate In Tea-seed Oil Found an an Effective Male Contraceptive

Mon, 11 May 2009 13:37:27 PST

( from http://www.rxpgnews.com ) Injectable testosterone could be the way to male contraception, that is effective, reversible, and minus serious short-term side-effects, according to a new study.

'For couples who can not, or prefer not to, use only female-oriented contraception, options have been limited to vasectomy, condom and withdrawal,' said Yi-Qun Gu, National Research Institute for Family Planning - in Beijing.

'Our study shows a male hormonal contraceptive regimen may be a potential, novel and workable alternative,' he added.

Gu said this study is the largest multi-centre, male hormonal contraceptive efficacy clinical trial of an androgen preparation in the world.

Participants included 1,045 healthy fertile Chinese men aged between 20-45 years. Each participant had fathered at least one child within the two years before the study and had a normal medical history.

Their female partners were between 18 and 38 years of age and had normal reproductive function.

Males were injected monthly with 500 mg of a formulation of testosterone undecanoate - in tea seed oil for 30 months. Results showed a cumulative contraceptive failure - rate of 1.1 per 100 men in the 24-month efficacy phase.

No serious adverse events were reported and reproductive function returned to the normal fertile reference range in all but two participants, said a NRIFP release.

'Despite the present encouraging results, the long-term safety of this hormonal male contraceptive regimen requires more extensive testing with a focus on cardiovascular, prostate and behavioural safety,' said Gu.

Persistent Sexual Arousal Syndrome Renamed As Restless Genital Syndrome

Sun, 28 Dec 2008 13:02:44 PST

( from http://www.rxpgnews.com ) Restless legs and overactive bladder could trigger imminent orgasms in women, according to a study.

Neuropsychiatrist Marcel Waldinger and his colleagues of Utrecht University and The Hague's HagaHospital studied 18 Dutch women with Persistent Sexual Arousal Syndrome -.

Their findings were recently published in the Journal of Sexual Medicine.

Women affected by this rare and mysterious syndrome experience persistent genital sensations as if they are continuously on the verge of an orgasm.

All participants received in depth interviews and various medical examinations such as MRI-scans of the brain and pelvis. The study showed that most women in this research also had restless legs, symptoms of an overactive bladder and pelvic varicosis.

'These results are a very important breakthrough in the research of this syndrome and show that this is a real physical disorder,' Waldinger emphasised.

In 2001, PSAS was mentioned for the first time in medical literature. Only 22 case reports have been described so far. A key feature of the syndrome is that sexual contact does not lead to diminishment but to aggravation of the symptoms. The complaints may lead to desperate and depressive feelings.

The majority of women in the study, the largest on PSAS so far, reported that their complaints were accompanied by restless legs and frequent urge to void.

Some of them reported to have restless legs symptoms long before their genital complaints. MRI-scan and ECHO-Doppler investigations of the pelvis and genitals also demonstrated a high prevalence of pelvic varicosis.

Notably, varicosis and restless legs are associated. The researchers are currently continuing their research on restless legs and bladder functioning in women with PSAS, said a Utrecht University release.

According to Waldinger, PSAS is a genital form of restless legs. Based on scientific observations, he postulated the view that the weird genital sensations are equivalent to the sensations belonging to the Restless Legs Syndrome.

'In order to emphasise this equivalence, we decided to change PSAS into Restless Genital Syndrome -', Waldinger explained.

RxPG News : Sexual Medicine

Injectable Testosterone Undecanoate In Tea-seed Oil Found an an Effective Male Contraceptive

Persistent Sexual Arousal Syndrome Renamed As Restless Genital Syndrome