http://www.rxpgnews.com/ Medical News and Information Thu, 21 Aug 2008 02:00:28 PST en-us http://www.rxpgnews.com/wnt/Wnt_-_One_Signal_Multiple_Pathways_Diversity_Comes_3925_3925.shtml WNT Type “Wnt” into Google Scholar, and you'll get nearly 72,000 hits, revealing the pivotal role this widely conserved family of signaling proteins plays in development and disease. Wnt proteins trigger complex signaling cascades that regulate cell growth, migration, differentiation, and many other aspects of development with the help of numerous interacting components. In the best-understood, “canonical” pathway, Wnt signaling molecules (called ligands) bind simultaneously to two coreceptors on the cell surface (Frizzled and LRP), allowing β-catenin proteins to stabilize (avoid destruction), enter the nucleus, associate with the transcription factor complex TCF/LEF, and activate genes involved in cell survival, proliferation, or differentiation. Inappropriate activation of β-catenin has been linked to several types of cancer. Wed, 05 Apr 2006 18:48:00 PST http://www.rxpgnews.com/wnt/Wnt_-_One_Signal_Multiple_Pathways_Diversity_Comes_3925_3925.shtml http://www.rxpgnews.com/wnt/Prostate_cancer_manipulates_Wnts_signaling_protein_2283_2283.shtml WNT Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful. Tue, 06 Sep 2005 20:40:00 PST http://www.rxpgnews.com/wnt/Prostate_cancer_manipulates_Wnts_signaling_protein_2283_2283.shtml http://www.rxpgnews.com/wnt/Ryk_Wnts_and_Frizzled3_receptors_in_neuronal_regen_2072_2072.shtml WNT The same family of chemical signals that attracts developing sensory nerves up the spinal cord toward the brain serves to repel motor nerves, sending them in the opposite direction, down the cord and away from the brain, report researchers at the University of Chicago in the September 2005 issue of Nature Neuroscience (available online August 14). The finding may help physicians restore function to people with paralyzing spinal cord injuries. Mon, 15 Aug 2005 20:49:00 PST http://www.rxpgnews.com/wnt/Ryk_Wnts_and_Frizzled3_receptors_in_neuronal_regen_2072_2072.shtml