XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
  Hypertension
  CAD
  Myocardial Infarction
  CHF
  Clinical Trials
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

Cardiology Channel
subscribe to Cardiology newsletter

Latest Research : Cardiology

   DISCUSS   |   EMAIL   |   PRINT
Genetic clues to cardiomyopathy's origins
Aug 19, 2006, 17:44, Reviewed by: Dr. Sanjukta Acharya

"We now have the genetic ability that is, making a diagnosis off of a blood test of the gene to evaluate these patients from the perspective of the disease's origin"

 
A genetic discovery sheds new light on the cause of cardiomyopathy and sudden death in young adults, which originates in the previously overlooked right ventricle of the heart, said a researcher at Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) in Houston.

In a report that appears online today in the journal Circulation Research, Dr. Jeffrey Towbin, professor of pediatrics at BCM and chief of pediatric cardiology at TCH, reports that a study in mice identifies conclusively for the first time genetic origins of cardiomyopathy, one of the leading causes of sudden cardiac death in young adults.

"We are getting to the underlying cause of this disease," said Towbin, principal investigator of the study. "For the first time, we have taken a human disease gene and put it into an animal model so that we can study its mechanisms in greater detail."

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a rare, progressive condition that causes diseased heart muscle and impairs cardiac function. In many cases, ARVC leads to fatigue, irregular heartbeat (arrhythmia), and, potentially, heart failure and sudden cardiac death.

In a previous study, Towbin and colleagues first identified mutations in the desmoplakin gene, which encodes a protein in the connecting junction between heart cells. In this study, funded by the National Institutes of Health and the National Heart, Lung, and Blood Institute, the authors implanted a mutant human desmoplakin gene into mice, which resulted in the mice's cardiac integrity being compromised, leading to dilation of the right ventricle, buildup of scar and fatty tissue, and arrhythmia.

Towbin calls ARVC "underrecognized" in the United States primarily because of its relative newness and difficulty evaluating the right ventricle technically, which can lead to misdiagnosis and improper treatment. Statistics of its prevalence in the United States have yet to be determined, but in Italy the disease is known to be the leading cause of sudden cardiac death in otherwise healthy young adults.

"ARVC is underrecognized here in the United States because of the novelty of the disorder and the lack of advances in technology that assess the right ventricle," said Towbin. "But I predict that in the next several years this will be shown to be a key player in sudden cardiac death."

The new findings will help pediatric and adult cardiology experts better understand the root cause of ARVC and advance the care of patients with this specific abnormality, Towbin said.

"We now have the genetic ability that is, making a diagnosis off of a blood test of the gene to evaluate these patients from the perspective of the disease's origin," said Towbin. "Hopefully we will be able to engineer new targeted therapies on the basis of these findings."
 

- Journal Circulation Research
 

www.bcm.edu

 
Subscribe to Cardiology Newsletter
E-mail Address:

 

Towbin's coauthors include first author Dr. Zhao Yang, of BCM, as well as contributors from Johns Hopkins University, University of Arizona, Harvard Medical School, and the University of Padua in Italy.

Related Cardiology News

Seven-point system gauges seriousness of heart failure in elderly
Uric acid levels closely related to hypertension in Blacks
American College of Cardiology announces new initiative to improve safety for patients with Acute Coronary Syndromes
Is TROPHY misleading?
Fortified orange juice decreases not only cholesterol but also CRP
Heart Disease: Blame it on genes!
Famotidine may help to slow progression of chronic heart failure
Atherothrombotic disease is not just a 'western' problem
Changing normal heart cells into pacemakers
Ilk gene underlies heart failure


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us