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Latest Research : Endocrinology Last Updated: Nov 17th, 2006 - 22:35:04

Latest Research : Endocrinology : Diabetes
Diabetes is an independent predictor of acute organ failure and subsequent death
Diabetes puts people at risk of developing critical illness and dying early, but obesity without diabetes does not. A study published today in the open access journal Critical Care reveals that individuals suffering from diabetes are three times more at risk of developing critical illness and dying young than individuals who do not have diabetes.
Sep 25, 2006, 18:47

Latest Research : Endocrinology
Better mothering skills and less stress
In the October 2006 issue of the journal Endocrinology, a collaborative research study by scientists at Cummings School of Veterinary Medicine at Tufts University and the University of Otago Medical School in Dunedin, New Zealand, shows that pregnancy and lactation in rodents produce long-term changes in hormone receptor actions in a mother's brain that may affect maternal behavior as well as her response to stress.

Sep 20, 2006, 23:31

Latest Research : Endocrinology
Statins also reduce complications associated with metabolic syndrome
UC Davis researchers have shown that statins not only improve cholesterol levels, but also dramatically reduce disease-causing inflammation in patients with metabolic syndrome — a condition defined by symptoms that include abdominal obesity and high blood pressure.
Sep 13, 2006, 20:15

Latest Research : Endocrinology : Diabetes : Insulin Resistance
Insulin resistance in early teens may predict diabetes
The body's decreased response to insulin beginning as early as age 13 may mean increased cardiovascular disease risk by age 19, according to research reported in Hypertension: Journal of the American Heart Association.
Aug 22, 2006, 20:26

Latest Research : Endocrinology
Low testosterone levels associated with increased risk of death in men
Men who have a low testosterone level after age 40 may have a higher risk of death over a four-year period than those with normal levels of the hormone, according to a report in the August 14/28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Unlike women undergoing menopause, middle-aged men generally do not experience a dramatic decrease in the production of sex hormones, according to background information in the article. Testosterone levels gradually decline as a man ages, decreasing approximately 1.5 percent per year after age 30. The effects of low testosterone levels include decreased muscle mass and bone density, insulin resistance, decreased sex drive, less energy, irritability and feelings of depression.
Aug 15, 2006, 12:19

Latest Research : Endocrinology : Diabetes
Low-fat vegan diet rivals oral diabetes medications
A low-fat vegan diet treats type 2 diabetes more effectively than a standard diabetes diet and may be more effective than single-agent therapy with oral diabetes drugs, according to a study in the August issue of Diabetes Care, a journal published by the American Diabetes Association. Study participants on the low-fat vegan diet showed dramatic improvement in four disease markers: blood sugar control, cholesterol reduction, weight control, and kidney function.
Aug 8, 2006, 00:38

Latest Research : Endocrinology : Diabetes
Conjugated linoleic acids in dairy products targets diabetes
Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.
Aug 4, 2006, 19:59

Latest Research : Endocrinology
Obesity, Diabetes and Infertility: Leptin answers all!
Twelve years ago, scientists discovered leptin—the now-famous hormone that controls appetite, burns calories and performs other crucial physiological activities as well. But the precise mechanism(s) by which leptin carries out these metabolic tasks is still controversial. Now, researchers at the Albert Einstein College of Medicine of Yeshiva University have shown how leptin exerts some of its most important effects.
Jul 6, 2006, 02:48

Latest Research : Endocrinology : Diabetes
TrialNet - Can Type 1 diabetes be prevented?
The project, called Type 1 Diabetes TrialNet, involves researchers at 22 clinical centers in the U.S. and in centers in Canada, Europe, Australia and New Zealand. The investigators will identify 100,000 persons at risk of developing type 1 diabetes and test interventions to prevent the onset of the disease.

Jul 6, 2006, 02:43

Latest Research : Endocrinology : Diabetes
Infections Link With diabetes
A major study has added weight to the theory that environmental factors such as common infections may be a trigger for diabetes in children and young adults. The study, the biggest of its kind, analysed information from a register of over 4,000 people aged 0-29 years old diagnosed with Type 1 diabetes over a 25-year period. The findings for young adults have not been published before. A quarter of a million people in the UK have Type 1 diabetes, and the number of cases in children is rising by three per cent each year. It develops if the body is unable to produce any insulin and usually appears before the age of 40.
Jul 3, 2006, 23:12

Latest Research : Endocrinology : Diabetes
Netrins hold potential for treating diabetes
University of Utah researchers have taken a potentially powerful new therapy for treating diabetes, peripheral vascular disease, and other illnesses out of the test tube and into animals by demonstrating it restores nerve and blood vessel growth in mice.
Jul 1, 2006, 16:04

Latest Research : Endocrinology : Diabetes
Coffee might reduce risk of type 2 diabetes
Drinking coffee, especially when it is decaffeinated, may be associated with a reduced risk of type 2 diabetes, according to a report in the June 26 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Jun 27, 2006, 03:52

Latest Research : Endocrinology : Diabetes : Insulin Resistance
Race may be risk factor for insulin resistance
Black women – even if their weight is normal – may be at increased risk for insulin resistance, a condition associated with diabetes, high blood pressure, and heart vessel disease, according to new research by Wake Forest University School of Medicine.
Jun 27, 2006, 02:57

Latest Research : Endocrinology : Diabetes
Impaired blood vessel responses seen in children of diabetics
The blood vessels of people whose parents both have type 2 diabetes do not respond as well to changes in blood flow as those of people without a family history of diabetes, even if they do not have diabetes themselves, according to a new study in the June 20, 2006, issue of the Journal of the American College of Cardiology.
Jun 21, 2006, 14:59

Latest Research : Endocrinology : Diabetes : Insulin Resistance
Elevation of fat-derived molecule RBP4 foretells early insulin resistance
A study in the June 15 issue of The New England Journal of Medicine (NEJM) reveals that elevated levels of a molecule called RBP4 (retinol binding protein 4) can foretell early stages in the development of insulin resistance, a major cause of type 2 diabetes as well as cardiovascular disease.
Jun 15, 2006, 16:39

Latest Research : Endocrinology : Diabetes
HbA1c Reduction of up to 2.8% with Vildagliptin Combination
Vildagliptin seeking to become a new once-daily oral treatment option for type 2 diabetes, has demonstrated impressive efficacy, especially in patients with poor glycemic control, as well as weight loss benefits in obese patients. The combination of Galvus (Vildagliptin), a member of the DPP-4 inhibitor class, and pioglitazone led to an overall 1.9% reduction in HbA1c (a measure of blood sugar control also known as A1c). Pioglitazone is an insulin sensitizer known as a thiazolidinedione, or TZD. Two-thirds of people (65%) on Galvus and pioglitazone achieved the ADA-defined A1c goal of less than or equal to 7% versus 42% of those who achieved this goal on monotherapy (Galvus 42.5%, pioglitazone 42.9%).
Jun 14, 2006, 19:32

Latest Research : Endocrinology : Diabetes
Altering GCN5 can control hepatic glucose release
Scientists at Johns Hopkins have uncovered a surprising and novel way of lowering blood sugar levels in mice by manipulating the release of sugar by liver cells. The results, published in the June issue of Cell Metabolism, have implications for treating conditions like diabetes.
Jun 8, 2006, 05:46

Latest Research : Endocrinology : Diabetes
Gardenia fruit compound genipin starting point for diabetes therapy
A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researchers report in the June 7, 2006, Cell Metabolism. The chemical therefore represents a useful starting point for new diabetes therapies, they said.
Jun 6, 2006, 23:48

Latest Research : Endocrinology : Diabetes
Nerve signals to pancreas after a meal determine blood sugar control
Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood sugar control, according to a report in the June 7, 2006, Cell Metabolism. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said.
Jun 6, 2006, 23:42

Latest Research : Endocrinology : Diabetes
Gene therapy prevents onset of hyperglycemia in diabetes prone mice
Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice by inserting a gene encoding for a cytokine -- a protein that stimulates or inhibits the proliferation or function of immune cells -- into their insulin-producing cells. According to the investigators, these findings, which are being presented at the American Society of Gene Therapy Annual Meeting in Baltimore, May 31 to June 4, have significant implications for the prevention of type 1 diabetes.
Jun 3, 2006, 09:50

Latest Research : Endocrinology : Diabetes
Causes of Adverse Reactions to Popular Type 2 Diabetes Drugs Pinpointed
Used by several million people worldwide, rosiglitazone (RSG) is an oral agent that helps patients with type 2 diabetes maintain good blood glucose levels by improving how their bodies use insulin. But RSG, like all the other thiazolidinedione (TZD) drugs that can lower blood glucose levels, can cause fluid retention (edema), a condition that puts patients at greater risk for weight gain, vascular complications and heart failure. Recently, the U.S. Food and Drug Administration and GlaxoSmithKline, which manufactures the drugs, reported cases of new onset or worsening macular edema (an eye disorder that leads to blurred or distorted vision) among patients who took RSG. While reports of these complications remain rare, GlaxoSmithKline has added a warning about the risks to the drugs’ labels.
Jun 3, 2006, 01:02

Latest Research : Endocrinology : Diabetes
Startling data unveiled about infection-induced amputation from landmark study on diabetic foot infection
Persons with diabetes who develop an infection are at a 55-fold greater risk for hospitalization, and an alarming 154-fold greater risk for amputation. These are some of the startling figures emanating from the first population-based study on diabetic foot infection. Researchers from Texas A&M University, Rosalind Franklin University of Medicine and Science, and the University of Washington collected data on nearly 1,700 patients over a two-year period.
Jun 2, 2006, 23:16

Latest Research : Endocrinology
A gene predisposing to pituitary adenomas identified
A recent Finnish study identifies a low-penetrance gene defect which predisposes carriers to intracranial tumors called pituitary adenomas. In particular individuals carrying the gene defect are susceptible to such tumors which secrete growth hormone. Excess of growth hormone results in conditions called acromegaly and gigantism. Identification of this gene defect using DNA-chip technologies is an example how genetic research can tackle more and more demanding tasks, such as identification of predisposition genes conferring a low absolute but high relative risk. The results are published in the May 26 issue of the journal Science.
May 26, 2006, 13:34

Latest Research : Endocrinology
Glutamate dehydrogenase mutation leads to hyperinsulinism
A recent study in the Journal of Biological Chemistry confirms that mutations in an enzyme called glutamate dehydrogenase can cause congenital hyperinsulinism. The research appears as the "Paper of the Week" in the June 2 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.
May 25, 2006, 12:37

Latest Research : Endocrinology
Testosterone patches help women with under-active pituitary glands
New research published today in The Journal of Clinical Endocrinology & Metabolism showed the first positive effect of testosterone on bone density, body composition and emotional, cognitive and behavioral function in women with low testosterone levels resulting from under-active pituitary glands.
May 10, 2006, 12:53

Latest Research : Endocrinology : Diabetes
Gene Variant T-87C Protects Against Type 2 Diabetes by Reducing aP2 Production
A rare gene variant in humans helps to protect against two of the country's top killers -- type 2 diabetes and heart disease -- as well as against hypertriglyceridemia, a condition that increases the risk of heart disease, obesity, and pancreatitis. A team of researchers from Harvard School of Public Health (HSPH) and the Channing Laboratory published their findings in this week's issue of the Proceedings of the National Academy of Sciences.
Apr 25, 2006, 19:54

Latest Research : Endocrinology : Diabetes
Lifestyle interventions needed to halt the increasing incidence of diabetes
More and more Americans are being diagnosed with diabetes. Is this rise in cases due to better testing, a change in diagnostic criteria, a true rise in incidence, or some combination of these and other factors? In a study in the May issue of the American Journal of Preventive Medicine, researchers from the Centers for Disease Control and Prevention examine some of the reasons for this increase. They conclude that obesity is a major factor in this recent increase of newly diagnosed diabetes. Lifestyle interventions that reduce or prevent the prevalence of obesity among persons at risk for diabetes are needed to halt the increasing incidence of this disease.
Apr 20, 2006, 15:58

Latest Research : Endocrinology : Diabetes
FDA Approves World's First Insulin Pump with Real-Time Continuous Glucose Monitoring
Medtronic, Inc. announced FDA approval of the MiniMed Paradigm® REAL-Time Insulin Pump and Continuous Glucose Monitoring System, a progressive new therapy available for patients who use insulin to treat diabetes. For the first time in the history of diabetes management, an insulin pump integrates with REAL-Time continuous glucose monitoring (CGM). This new technology will help patients take immediate corrective or preventive action to maintain healthy glucose levels and delay or prevent diabetes-related complications, including coma, blindness, kidney failure, amputation, impotence, and heart disease.
Apr 15, 2006, 18:56

Latest Research : Endocrinology : Diabetes
Self monitoring and A1c should be used together in diabetes monitoring
In a strongly worded review published in the recent edition of The Journal of the American Medical Association (JAMA), the head of the Johns Hopkins Diabetes Center urges physicians and patients to better use the blood-testing tools at hand to manage the disease and prevent most of its dire impact on the heart, kidneys, nerves and vision.
Apr 15, 2006, 18:11

Latest Research : Endocrinology
Hap1 protein links circulating insulin to feeding behavior regulating brain circuits
Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition.
Apr 10, 2006, 14:11


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Chief Medical Editor: Dr Sanjukta Acharya; Managing Editor & Founder: Dr Himanshu Tyagi; Editors: Dr Rashmi Yadav, Dr Ankush Vidyarthi; Chief Correspondent: Dr Priya Saxena
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