||Last Updated: Nov 17th, 2006 - 22:35:04
Diabetes is an independent predictor of acute organ failure and subsequent death
Diabetes puts people at risk of developing critical illness and dying early, but obesity without diabetes does not. A study published today in the open access journal Critical Care reveals that individuals suffering from diabetes are three times more at risk of developing critical illness and dying young than individuals who do not have diabetes.
Sep 25, 2006, 18:47
Insulin resistance in early teens may predict diabetes
The body's decreased response to insulin beginning as early as age 13 may mean increased cardiovascular disease risk by age 19, according to research reported in Hypertension: Journal of the American Heart Association.
Aug 22, 2006, 20:26
Low-fat vegan diet rivals oral diabetes medications
A low-fat vegan diet treats type 2 diabetes more effectively than a standard diabetes diet and may be more effective than single-agent therapy with oral diabetes drugs, according to a study in the August issue of Diabetes Care, a journal published by the American Diabetes Association. Study participants on the low-fat vegan diet showed dramatic improvement in four disease markers: blood sugar control, cholesterol reduction, weight control, and kidney function.
Aug 8, 2006, 00:38
Conjugated linoleic acids in dairy products targets diabetes
Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.
Aug 4, 2006, 19:59
TrialNet - Can Type 1 diabetes be prevented?
The project, called Type 1 Diabetes TrialNet, involves researchers at 22 clinical centers in the U.S. and in centers in Canada, Europe, Australia and New Zealand. The investigators will identify 100,000 persons at risk of developing type 1 diabetes and test interventions to prevent the onset of the disease.
Jul 6, 2006, 02:43
Infections Link With diabetes
A major study has added weight to the theory that environmental factors such as common infections may be a trigger for diabetes in children and young adults. The study, the biggest of its kind, analysed information from a register of over 4,000 people aged 0-29 years old diagnosed with Type 1 diabetes over a 25-year period. The findings for young adults have not been published before. A quarter of a million people in the UK have Type 1 diabetes, and the number of cases in children is rising by three per cent each year. It develops if the body is unable to produce any insulin and usually appears before the age of 40.
Jul 3, 2006, 23:12
Netrins hold potential for treating diabetes
University of Utah researchers have taken a potentially powerful new therapy for treating diabetes, peripheral vascular disease, and other illnesses out of the test tube and into animals by demonstrating it restores nerve and blood vessel growth in mice.
Jul 1, 2006, 16:04
Coffee might reduce risk of type 2 diabetes
Drinking coffee, especially when it is decaffeinated, may be associated with a reduced risk of type 2 diabetes, according to a report in the June 26 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Jun 27, 2006, 03:52
Race may be risk factor for insulin resistance
Black women – even if their weight is normal – may be at increased risk for insulin resistance, a condition associated with diabetes, high blood pressure, and heart vessel disease, according to new research by Wake Forest University School of Medicine.
Jun 27, 2006, 02:57
Impaired blood vessel responses seen in children of diabetics
The blood vessels of people whose parents both have type 2 diabetes do not respond as well to changes in blood flow as those of people without a family history of diabetes, even if they do not have diabetes themselves, according to a new study in the June 20, 2006, issue of the Journal of the American College of Cardiology.
Jun 21, 2006, 14:59
Elevation of fat-derived molecule RBP4 foretells early insulin resistance
A study in the June 15 issue of The New England Journal of Medicine (NEJM) reveals that elevated levels of a molecule called RBP4 (retinol binding protein 4) can foretell early stages in the development of insulin resistance, a major cause of type 2 diabetes as well as cardiovascular disease.
Jun 15, 2006, 16:39
HbA1c Reduction of up to 2.8% with Vildagliptin Combination
Vildagliptin seeking to become a new once-daily oral treatment option for type 2 diabetes, has demonstrated impressive efficacy, especially in patients with poor glycemic control, as well as weight loss benefits in obese patients. The combination of Galvus (Vildagliptin), a member of the DPP-4 inhibitor class, and pioglitazone led to an overall 1.9% reduction in HbA1c (a measure of blood sugar control also known as A1c). Pioglitazone is an insulin sensitizer known as a thiazolidinedione, or TZD. Two-thirds of people (65%) on Galvus and pioglitazone achieved the ADA-defined A1c goal of less than or equal to 7% versus 42% of those who achieved this goal on monotherapy (Galvus 42.5%, pioglitazone 42.9%).
Jun 14, 2006, 19:32
Altering GCN5 can control hepatic glucose release
Scientists at Johns Hopkins have uncovered a surprising and novel way of lowering blood sugar levels in mice by manipulating the release of sugar by liver cells. The results, published in the June issue of Cell Metabolism, have implications for treating conditions like diabetes.
Jun 8, 2006, 05:46
Gardenia fruit compound genipin starting point for diabetes therapy
A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researchers report in the June 7, 2006, Cell Metabolism. The chemical therefore represents a useful starting point for new diabetes therapies, they said.
Jun 6, 2006, 23:48
Nerve signals to pancreas after a meal determine blood sugar control
Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood sugar control, according to a report in the June 7, 2006, Cell Metabolism. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said.
Jun 6, 2006, 23:42
Gene therapy prevents onset of hyperglycemia in diabetes prone mice
Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice by inserting a gene encoding for a cytokine -- a protein that stimulates or inhibits the proliferation or function of immune cells -- into their insulin-producing cells. According to the investigators, these findings, which are being presented at the American Society of Gene Therapy Annual Meeting in Baltimore, May 31 to June 4, have significant implications for the prevention of type 1 diabetes.
Jun 3, 2006, 09:50
Causes of Adverse Reactions to Popular Type 2 Diabetes Drugs Pinpointed
Used by several million people worldwide, rosiglitazone (RSG) is an oral agent that helps patients with type 2 diabetes maintain good blood glucose levels by improving how their bodies use insulin. But RSG, like all the other thiazolidinedione (TZD) drugs that can lower blood glucose levels, can cause fluid retention (edema), a condition that puts patients at greater risk for weight gain, vascular complications and heart failure. Recently, the U.S. Food and Drug Administration and GlaxoSmithKline, which manufactures the drugs, reported cases of new onset or worsening macular edema (an eye disorder that leads to blurred or distorted vision) among patients who took RSG. While reports of these complications remain rare, GlaxoSmithKline has added a warning about the risks to the drugs’ labels.
Jun 3, 2006, 01:02
Startling data unveiled about infection-induced amputation from landmark study on diabetic foot infection
Persons with diabetes who develop an infection are at a 55-fold greater risk for hospitalization, and an alarming 154-fold greater risk for amputation. These are some of the startling figures emanating from the first population-based study on diabetic foot infection. Researchers from Texas A&M University, Rosalind Franklin University of Medicine and Science, and the University of Washington collected data on nearly 1,700 patients over a two-year period.
Jun 2, 2006, 23:16
Gene Variant T-87C Protects Against Type 2 Diabetes by Reducing aP2 Production
A rare gene variant in humans helps to protect against two of the country's top killers -- type 2 diabetes and heart disease -- as well as against hypertriglyceridemia, a condition that increases the risk of heart disease, obesity, and pancreatitis. A team of researchers from Harvard School of Public Health (HSPH) and the Channing Laboratory published their findings in this week's issue of the Proceedings of the National Academy of Sciences.
Apr 25, 2006, 19:54
Lifestyle interventions needed to halt the increasing incidence of diabetes
More and more Americans are being diagnosed with diabetes. Is this rise in cases due to better testing, a change in diagnostic criteria, a true rise in incidence, or some combination of these and other factors? In a study in the May issue of the American Journal of Preventive Medicine, researchers from the Centers for Disease Control and Prevention examine some of the reasons for this increase. They conclude that obesity is a major factor in this recent increase of newly diagnosed diabetes. Lifestyle interventions that reduce or prevent the prevalence of obesity among persons at risk for diabetes are needed to halt the increasing incidence of this disease.
Apr 20, 2006, 15:58
FDA Approves World's First Insulin Pump with Real-Time Continuous Glucose Monitoring
Medtronic, Inc. announced FDA approval of the MiniMed Paradigm® REAL-Time Insulin Pump and Continuous Glucose Monitoring System, a progressive new therapy available for patients who use insulin to treat diabetes. For the first time in the history of diabetes management, an insulin pump integrates with REAL-Time continuous glucose monitoring (CGM). This new technology will help patients take immediate corrective or preventive action to maintain healthy glucose levels and delay or prevent diabetes-related complications, including coma, blindness, kidney failure, amputation, impotence, and heart disease.
Apr 15, 2006, 18:56
Self monitoring and A1c should be used together in diabetes monitoring
In a strongly worded review published in the recent edition of The Journal of the American Medical Association (JAMA), the head of the Johns Hopkins Diabetes Center urges physicians and patients to better use the blood-testing tools at hand to manage the disease and prevent most of its dire impact on the heart, kidneys, nerves and vision.
Apr 15, 2006, 18:11
Significant improvement noted in diabetes management using chronic care model
Educating people with diabetes in a primary-care setting with sustained, comprehensive intervention resulted in significant improvement in disease management and overall health, according to a study published in the current issue of Diabetes Care, a journal of the American Diabetes Association (ADA). In the study, University of Pittsburgh Diabetes Institute researchers report the first evidence from a randomized, controlled clinical trial to show a clear association between a more comprehensive approach to diabetes management and improved health.
Apr 5, 2006, 14:45
Researchers reverse juvenile diabetes in animal model
Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center researchers Massimo Trucco, MD, and Nick Giannoukakis, PhD, observed marked amelioration of diabetes in a mouse model by a novel treatment strategy involving specific modification of the animal's own dendritic cells, thereby reversing diabetes in animal studies.
Mar 28, 2006, 21:44
Too much or too little sleep increases diabetes risk
Men who sleep too much or too little are at an increased risk of developing Type 2 diabetes, according to a study by the New England Research Institutes in collaboration with Yale School of Medicine researchers.
Mar 27, 2006, 00:31
Diabetic patients often overestimate healthy body weight
Heavier patients with diabetes are more likely to overestimate their "healthiest" body weight compared to those of normal weight, according to a study published in the current issue of Diabetes Care.
Mar 13, 2006, 20:29
Puberty is a key developmental period affecting diabetes risk
Insulin levels in African American children worsen as they progress through puberty while those same levels don't change in their Caucasian counterparts, says new University of Alberta research that shows puberty is a key developmental period affecting diabetes risk.
Mar 11, 2006, 01:01
Researchers reveal mechanisms behind Thiazolidinediones in type 2 diabetes
Thiazolidinediones (TZD's) are drugs commonly prescribed to patients with type 2 diabetes, the most common form of diabetes. Current U.S. Food and Drug Administration-approved agents are known as Actos (pioglitazone) and Avandia (rosiglitazone). These oral agents improve blood glucose levels in people with diabetes by improving insulin action in the body. While it is known that these drugs work primarily by binding to a receptor in the nucleus of cells called Peroxisome Proliferator Activated Receptor-gamma (PPARg), all of the molecular signaling events important for the drugs to work are not completely understood.
Mar 11, 2006, 00:51
Effect of diabetes on heart may differ by ethnicity
Diabetes strongly increases the risk of heart failure in all ethnic groups, but early effects of diabetes on the heart may differ depending on whether the subjects are white, African-American, Hispanic or Chinese. These results emerged from the Multi-Ethnic Study of Atherosclerosis (MESA) when the investigators focused on heart mass – the weight of the heart muscle as measured by MRI, according to Alain Bertoni, M.D., M.P.H., at Wake Forest University School of Medicine.
Mar 8, 2006, 21:47
Pig cells could provide diabetes cure
Pig body parts, already used in treating many human ailments, could also provide a cure for diabetes within a decade, say scientists.
Feb 22, 2006, 16:12