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Last Updated: Jan 5, 2010 - 3:04:54 PM |
Latest Research
Researchers revisit pulmonary arterial hypertension survival
Setting out to determine the survival of patients with pulmonary arterial hypertension (PAH), researchers at the University of Chicago Medical Center and their colleagues also discovered that an equation used for more than 20 years to predict survival is outdated. Accordingly, they developed and recently published a new survival prediction equation that will impact clinical practice and the drug development process.
Jan 6, 2010 - 4:59:12 AM
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Latest Research
H1N1 more risky than seasonal flu in children with sickle cell disease
Infection with the H1N1 virus, or swine flu, causes more life-threatening complications than seasonal flu in children with sickle cell disease, according to research from Johns Hopkins Children's Center. The findings, to be presented on Dec. 7 at the annual meeting of the American Society of Hematology, warn parents and caregivers that such children are more likely to need emergency treatment and stays in an intensive-care unit.
Dec 7, 2009 - 4:59:36 AM
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Latest Research
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Haematology
Vital discovery may save many from traumatic deaths
Researchers have unravelled how certain proteins can enter the bloodstream and begin to kill the lining of blood vessels, resulting in uncontrolled internal bleeding. Their discovery could help save thousands from traumatic deaths, caused by car crashes or on the battlefield.
Nov 5, 2009 - 3:06:20 PM
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Latest Research
The American Society of Hematology to honor inspirational hematologists with Mentor Awards
(WASHINGTON, November 3, 2009) - The American Society of Hematology (ASH) is honoring two prominent hematologists with ASH Mentor Awards in recognition of the important role they play in the training and career development of hematologists early in their careers. Stuart H. Orkin, MD, and Arthur W. Nienhuis, MD, will receive their awards during the 51st ASH Annual Meeting in New Orleans.
Nov 3, 2009 - 4:59:36 AM
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Latest Research
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Cardiology
Transfusions Risky For Cardiac Patients
Blood transfusion to hospitalised cardiac patients doubles the risk of infection and quadruples the risk of death, according to a new study.
Aug 8, 2009 - 1:45:23 PM
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Latest Research
NHLBI stops study of pulmonary hypertension treatment in sickle cell patients
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial testing a drug treatment for pulmonary hypertension in adults with sickle cell disease nearly one year early due to safety concerns. In an interim review of safety data from 33 participants who completed 16 weeks of treatment, researchers found that, compared to participants on placebo (dummy pill), participants taking sildenafil (Revatio) were significantly more likely to have serious medical problems. The most common problem was episodes of severe pain called sickle cell crises, which resulted in hospitalization. No deaths have been associated with the drug in the clinical trial.
Jul 28, 2009 - 3:59:36 AM
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Latest Research
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Cardiology
Anemia linked with higher death risk in heart patients
The presence of anaemia in patients with chronic heart failure is linked to a significantly higher risk of death.
Jun 18, 2009 - 3:42:04 PM
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Latest Research
Common chemotherapy drug triggers fatal allergic reactions
CHICAGO -- A chemotherapy drug that is supposed to help save cancer patients' lives, instead resulted in life-threatening and sometimes fatal allergic reactions.
Jun 8, 2009 - 3:59:36 AM
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Latest Research
Canadian biomedical engineering pioneer receives international award
Countless individuals around the world are alive because of him. His 40 plus years of research have helped to make the use of life-saving devices such as prosthetic heart valves, vascular stents, vascular grafts, heart-assist devices, and heart-lung bypass systems almost commonplace. In the process, he has helped to establish Canada as a biomaterials leader.
Apr 23, 2009 - 3:59:36 AM
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Latest Research
Potential breakthrough for T-Cell lymphoma patients with drug that mimics folic acid
NEW YORK (Dec. 8, 2008) -- Preliminary results of a pivotal Phase 2 clinical trial of pralatrexate (PDX), a drug that partially works by mimicking folic acid, showed a complete or partial response in 27 percent of patients with recurrent or resistant peripheral T-cell lymphoma (PTCL). PROPEL (Pralatrexate in patients with Relapsed Or refractory PEripheral T-cell Lymphoma) findings were presented by the study's principal investigator, Dr. Owen A. O'Connor of the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital, at the 50th Annual Meeting of the American Society of Hematology (ASH) in San Francisco.
Dec 9, 2008 - 4:59:37 AM
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Latest Research
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Haematology
Bone marrow stem cell niche discovered
Researchers have identified the precise location of the bone marrow stem cell niche.
Dec 7, 2008 - 5:36:10 PM
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Latest Research
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Haematology
Transcranial Doppler ultrasonography screening helps in preventing strokes in children with sickle cell disease
Screening with an ultrasound machine has proved highly successful in preventing stroke among children with sickle cell disease, by identifying children who are then preventively treated with blood transfusions. Over an eight-year period at The Children's Hospital of Philadelphia, researchers found that the technique, transcranial Doppler ultrasonography (TCD), along with regular transfusions for children found to be at high risk, reduced stroke to one-tenth of the incidence found before TCD was introduced.
Dec 7, 2008 - 2:10:21 PM
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Latest Research
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Haematology
Evaluation of new anti-coagulant drugs
The largest study ever to examine the preventive use of blood-thinning medication to help prevent deadly blood clots in patients with cancer undergoing chemotherapy was presented in a press conference during the 50th Annual Meeting of the American Society of Hematology in San Francisco, CA. Additional research featured at the press conference includes studies that examine the use of three different investigational blood-thinning medications that belong to a new class of therapies called Factor Xa inhibitors.
Dec 7, 2008 - 2:01:46 PM
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Latest Research
Researchers aim to over-stress already taxed mantle cell lymphoma cells
AUGUSTA, Ga. - Cancer cells are already stressed by the fast pace they require to grow and spread and scientists believe a little more stress just may kill them.
Nov 10, 2008 - 4:59:37 AM
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Latest Research
'Old blood' linked to infection
Blood stored for 29 days or more, nearly 2 weeks less than the current standard for blood storage, is associated with a higher infection rate in patients who received transfusions with the blood. In a new study presented at CHEST 2008, the 74th annual international scientific assembly of the American College of Chest Physicians (ACCP), researchers found that patients who received transfusions with blood stored for 29 days or more were twice as likely to suffer from nosocomial infections, including pneumonia, upper respiratory infections, and sepsis, with the oldest blood being associated with the most infections. Currently, federal regulations allow red blood cells to be stored up to 42 days, after which they must be discarded.
Oct 28, 2008 - 3:59:37 AM
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Latest Research
Einstein and Montefiore receive grants to expand disease-focused stem cell research
The Empire State Stem Cell Board has awarded research planning grants to Albert Einstein College of Medicine and to Montefiore Medical Center. The grants, totaling $238,000, are part of $2 million in grants announced by State Health Commissioner Richard F. Daines, M.D. The funding, awarded to 18 medical colleges, medical centers and labs will strengthen New York State's capacity for stem cell research and could lead to the development of new therapies for Alzheimer's, diabetes, Parkinson's, ALS and other conditions.
Oct 3, 2008 - 3:59:37 AM
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Latest Research
High blood pressure takes big toll on small filtering units of the kidney
Take a kidney out of the body and it still knows how to filter toxins from the blood.
Sep 19, 2008 - 3:59:37 AM
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Latest Research
Better understanding of blood vessel constrictor needed to harness its power for patients
To harness endothelin-1's power to constrict blood vessels and help patients manage high blood pressure or heart failure, scientists must learn more about how endothelin functions naturally and in disease states, says a Medical College of Georgia researcher.
Sep 18, 2008 - 3:59:37 AM
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Latest Research
'Cancer was one of the best things to happen to me... but I worry about the future'
London, UK: For Dan Savage, surviving testicular cancer has been a spur to him making the most of his life and taking more adventurous decisions, and he says, that in retrospect, it was probably one of the best things that has happened to him. But as he approaches the end of his fifth year in remission from the disease, when he will be signed off as cured by the medical profession, he worries that from now on he will have no regular medical checks that might pick up early signs of the cancer returning. It will be down to him to contact the cancer clinic if he is worried about any new symptoms.
Jun 10, 2008 - 3:59:37 AM
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Latest Research
Cancer incidence and mortality in young people decreases with increasing deprivation
London, UK: Results of research into the associations between cancer and socio-economic deprivation and affluence have shown that, in contrast to cancers in older people, the numbers of new cases and deaths from the disease in teenagers and young adults (TYAs) decrease with increasing deprivation.
Jun 9, 2008 - 3:59:37 AM
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Latest Research
Teenagers and young adults with cancer can face long delays before finally being diagnosed
London, UK: Three studies to be presented at Teenage Cancer Trust's Fifth International Conference on Teenage and Young Adult Cancer Medicine today (Monday) have thrown light on the extent of delays that teenagers and young adults (TYAs) can face before being diagnosed with cancer, and on some of the reasons why this happens.
Jun 8, 2008 - 3:59:37 AM
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Latest Research
First early-detection blood test for Parkinson's shows promise
NEW YORK (March 11, 2008) -- A test that profiles molecular biomarkers in blood could become the first accurate diagnostic test for Parkinson's disease, new research shows.
Mar 11, 2008 - 3:59:37 AM
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Latest Research
Eltrombopag effective for hepatitis C patients with low blood-platelet counts
NEW YORK (Dec. 28, 2007) -- For patients with hepatitis C, having a low blood platelet count is a frequent complication associated with advanced disease. This problem is compounded by the fact that standard antiviral treatment for the disease can further reduce platelet numbers to dangerously low levels, effectively denying these patients the treatment they urgently need. Now, research published in the New England Journal of Medicine finds that a new drug, eltrombopag, appears to significantly boost platelet counts, opening the door to effective treatment.
Dec 28, 2007 - 4:59:37 AM
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Latest Research
Light and sound -- the way forward for better medical imaging
Detection and treatment of tumours, diseased blood vessels and other soft-tissue conditions could be significantly improved, thanks to an innovative imaging system being developed that uses both light and sound.
Dec 12, 2007 - 4:59:37 AM
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Latest Research
Children with sickle cell disease, silent strokes show some relief with blood transfusions
A group of children who have sickle cell disease and who experience silent strokes showed some relief from the silent strokes with blood transfusion therapy, researchers at Washington University School of Medicine in St. Louis have found.
Dec 10, 2007 - 4:59:37 AM
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Latest Research
Study proposes new theory of how viruses may contribute to cancer
PITTSBURGH, Oct. 23 – A new study suggests that viruses may contribute to cancer by causing excessive death to normal cells while promoting the growth of surviving cells with cancerous traits. Viruses may act as forces of natural selection by wiping out normal cells that support the replication of viruses and leaving behind those cells that have acquired defects in their circuitry. When this process is repeated over and over, cancer can develop say study authors, led by Preet M. Chaudhary, M.D., Ph.D., professor of medicine at the University of Pittsburgh School of Medicine. Their findings are published by Public Library of Science in the Oct. 24 issue of PLoS ONE.
Oct 23, 2007 - 3:59:37 AM
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Latest Research
Chemistry turns killer gas into potential cure
Despite its deadly reputation, the gas carbon monoxide (CO) could actually save lives and boost health in future as a result of leading-edge UK research.
Oct 15, 2007 - 3:59:37 AM
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Latest Research
Anticlotting drug found to be safe in sickle cell patients
CHAPEL HILL - An intravenous “blood thinner” widely used in patients with acute coronary syndromes and during coronary artery stent placement appears to be safe in patients with sickle cell disease and may have beneficial anti-inflammatory effects, a small study at the University of North Carolina at Chapel Hill School of Medicine has found.
Oct 11, 2007 - 3:59:37 AM
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Latest Research
MIT uncovers key blood protein
CAMBRIDGE, MA--Scientists working in the only lab at MIT doing hematology research have uncovered a protein that plays a key role in the recycling of iron from blood.
Oct 11, 2007 - 3:59:37 AM
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Latest Research
Daisies lead scientists down path to new leukemia drug
A new, easily ingested form of a compound that has already shown it can attack the roots of leukemia in laboratory studies is moving into human clinical trials, according to a new article by University of Rochester investigators in the journal, Blood.
Oct 2, 2007 - 3:59:37 AM
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Latest Research
Novel strategy under study for aggressive leukemia
A novel strategy to hopefully beat into oblivion one of the most aggressive forms of acute myelogenous leukemia combines the strengths of some of the newest leukemia agents, researchers say.
Sep 24, 2007 - 3:59:37 AM
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Latest Research
Sexual function affected by stem cell transplant according to long-term study
WASHINGTON, Sept. 18, 2007 -- A long-term study found that a type of stem cell transplant used for patients with life-threatening diseases, such as leukemia and lymphoma, results in decreased sexual function and activity for recipients. Further, males are likely to recover from these changes over time, while the sexuality of female patients remains compromised. In addition, neither male nor female long-term cancer survivors regained levels of sexual activity and function equal to those of their peers who have not had cancer, according to a Blood First Edition Paper prepublished online today. Blood is the official journal of the American Society of Hematology.
Sep 18, 2007 - 3:59:37 AM
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Latest Research
Unique role for blood formation gene identified
Hanover, NH--All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found. Their research reveals an unexpected role for the gene in sustaining the adult blood-forming system, and opens novel strategies for targeting the gene, which is often involved in a type of childhood leukemia.
Sep 12, 2007 - 3:59:37 AM
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Latest Research
Small animal imaging facility is big boon to research
When powerful magnets line up the body’s protons before radiofrequency waves can grab their attention away, it’s called spin physics.
Aug 30, 2007 - 3:59:37 AM
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Latest Research
New cancer fighter may help ICU patients beat infections
HSP 90 inhibitors, which are finding favor in fighting cancer, may also help battle overwhelming infection in intensive care patients, researchers say.
Aug 27, 2007 - 3:59:37 AM
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Latest Research
Bench-to-bedside look at MSC research at Case Western Reserve conference in Cleveland
CLEVELAND—Researchers from 22 countries will come to Cleveland for a bench to bedside examination of the developing mesenchymal stem cells (MSC) from regenerative medicine and stem cell research to therapeutics in patient care. The National Center for Regenerative Medicine for Stem Cell and Regenerative Medicine (NCRM) and founding partner Case Western Reserve University have organized the 2007 Adult Mesenchymal Stem Cells in Regenerative Medicine Conference, August 27-29, at the Marriott Hotel in downtown Cleveland, to highlight advances in MSC research. The conference is the first organized by the two groups on MSCs.
Aug 24, 2007 - 3:59:37 AM
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Latest Research
Better life support for artificial liver cells
COLUMBUS , Ohio -- Researchers at Ohio State University are developing technology for keeping liver cells alive and functioning normally inside bioartificial liver-assist devices (BLADs).
Aug 23, 2007 - 3:59:37 AM
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Latest Research
Tumors use enzyme to recruit regulatory T-cells and suppress immune response
One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.
Aug 16, 2007 - 3:59:37 AM
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Latest Research
New study shows promise in reducing surgical risks associated with surgical bleeding
CHICAGO (August 10, 2007) – Surgeons may have a new patient safety tool to stop moderate surgical bleeding without some of the concerns associated with the current standard blood-clotting treatment. New research published in the August issue of the Journal of the American College of Surgeons shows that recombinant human thrombin (rhThrombin) reduces the risk of surgical complications associated with the use of plasma-derived bovine thrombin (bThrombin), which is currently the only commercially available stand-alone thrombin used to improve clotting during surgical procedures and stop bleeding.
Aug 10, 2007 - 3:59:37 AM
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Latest Research
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
RICHMOND, Va. (Aug. 6, 2007) – Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.
Aug 6, 2007 - 3:59:37 AM
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Latest Research
Study shows radiofrequency ablation highly effective in treating kidney tumors
The patients underwent CT-guided radiofrequency ablation (RFA) at Wake Forest Baptist for kidney tumors ranging in size from 0.6 cm to 8.8 cm. A total of 125 tumors in 104 patients were treated over the period 2000 to 2006. In all of the patients, a biopsy had confirmed the presence of renal cell carcinomas (RCC), a common type of renal malignancy.
Aug 1, 2007 - 3:59:37 AM
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Latest Research
Scientists find why red beans and rice can be nauseating
People cry foul when fowl is undercooked, but what about red beans and rice
Aug 1, 2007 - 3:59:37 AM
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Latest Research
Penn researchers discover pathway that eliminates genetic defects in red blood cells
PHILADELPHIA – Researchers at the University of Pennsylvania School of Medicine have discovered a unique molecular pathway that detects and selectively eliminates defective messenger RNAs from red blood cells. Other such pathways – known as surveillance pathways – operate in a more general way, in many cell types. Knowing how this specific surveillance system works can help researchers better understand hereditary diseases, in this case, thalassemia, a form of anemia, which is the most common genetic disorder worldwide.
Aug 1, 2007 - 3:59:37 AM
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Latest Research
Aggressive therapy best for certain AML patients
COLUMBUS , Ohio – A new study suggests that acute leukemia patients whose cancer cells show a genetic change that usually predicts a swift return of the disease following remission may remain disease-free longer when given aggressive therapy.
Aug 1, 2007 - 3:59:37 AM
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Latest Research
First case of successful ovarian tissue transplantation between two, nonidentical sisters
A woman, whose ovaries had failed due to damage caused by chemotherapy and radiotherapy, has received a successful ovarian transplant from her genetically non-identical sister. The transplant restored her ovarian function, she started to menstruate and, after a year, doctors were able to recover two mature oocytes from her ovaries and fertilise them to produce two embryos.
Aug 1, 2007 - 3:59:37 AM
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Latest Research
Promising treatment target found in Hodgkin lymphoma
BOSTON--Dana-Farber Cancer Institute scientists have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. Based on this finding, the researchers are now investigating targeted therapies to disable this molecular bodyguard and boost a patient's ability to fight the blood cancer.
Jul 30, 2007 - 3:59:37 AM
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Latest Research
UB scientist discovers novel iron-copper alliance
BUFFALO, N.Y. -- Iron is the workhorse of trace minerals. An essential component of red blood cells, disruption of iron levels in the body will result in a myriad of serious conditions, and life cannot be sustained without it. In novel research, investigators at the University at Buffalo’s School of Public Health and Health Professions, have learned that iron is only one half of an all-important duo of trace minerals -- the other being copper -- that work in tandem to maintain proper iron balance, or homeostasis. It appears the workhorse has a helper. James F. Collins, Ph.D., UB assistant professor of exercise and nutrition sciences and biochemistry, discovered that when iron-absorption by cells lining the small intestine decreases during iron-deficient states, copper absorption increases. Collins now is exploring the relationship between these two trace minerals through a $1.38 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The work will be carried out using established models of intestinal iron absorption in humans, including iron and iron/copper-deficient rodents and cultured intestinal epithelial cells. “This project is intended to test the overall hypothesis that increased copper transport during iron-deficiency is critical to enhance certain aspects of intestinal iron absorption,” said Collins. “Iron or copper deficiency causes anemia, and abnormal intestinal iron transport is associated with several common human pathologies, including anemia of chronic disease (ACD) and hereditary hemochromatosis (HH), different forms of which result from several common genetic defects.” HH is an inherited metabolic disorder characterized by abnormally high absorption of dietary iron, which is deposited in body tissues and organs, where it may become toxic. ACD is a blood disorder caused by low body iron levels resulting from any medical condition that affects the production and lifespan of red blood cells, such as chronic infection, chronic immune activation resulting in inflammation, or malignancy.
Jul 23, 2007 - 3:59:37 AM
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Latest Research
Effects of aging in stem cells
There is little disagreement that the body’s maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why. Stem cells combat the aging process by replenishing old or damaged cells—particularly in the skin, gut, and blood—with a fresh supply to maintain and repair tissue. Unfortunately, new evidence published in the open-access journal PLoS Biology suggests that this regenerative capacity also declines with age as stem cells acquire functional defects.
Jul 23, 2007 - 3:59:37 AM
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Latest Research
Computers pass dosage test for thrombosis drugs
The largest ever study into the administration of blood thinning drugs like Warfarin has concluded that dosages calculated by computer are at least as safe and reliable as those provided by trained medical professionals.
Jul 19, 2007 - 3:59:37 AM
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Latest Research
Enzyme eliminated by cancer cells holds promise for cancer treatment
An enzyme that cancer cells eliminate, apparently so they can keep proliferating, may hold clues to more targeted, effective cancer treatment, scientists say.
Jul 18, 2007 - 3:59:37 AM
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