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Last Updated: Sep 8, 2007 - 1:21:03 PM |
Latest Research
Small animal imaging facility is big boon to research
When powerful magnets line up the body’s protons before radiofrequency waves can grab their attention away, it’s called spin physics.
Aug 30, 2007 - 4:00:00 AM
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Latest Research
New cancer fighter may help ICU patients beat infections
HSP 90 inhibitors, which are finding favor in fighting cancer, may also help battle overwhelming infection in intensive care patients, researchers say.
Aug 27, 2007 - 4:00:00 AM
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Latest Research
Bench-to-bedside look at MSC research at Case Western Reserve conference in Cleveland
CLEVELAND—Researchers from 22 countries will come to Cleveland for a bench to bedside examination of the developing mesenchymal stem cells (MSC) from regenerative medicine and stem cell research to therapeutics in patient care. The National Center for Regenerative Medicine for Stem Cell and Regenerative Medicine (NCRM) and founding partner Case Western Reserve University have organized the 2007 Adult Mesenchymal Stem Cells in Regenerative Medicine Conference, August 27-29, at the Marriott Hotel in downtown Cleveland, to highlight advances in MSC research. The conference is the first organized by the two groups on MSCs.
Aug 24, 2007 - 4:00:00 AM
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Latest Research
Better life support for artificial liver cells
COLUMBUS , Ohio -- Researchers at Ohio State University are developing technology for keeping liver cells alive and functioning normally inside bioartificial liver-assist devices (BLADs).
Aug 23, 2007 - 4:00:00 AM
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Latest Research
Tumors use enzyme to recruit regulatory T-cells and suppress immune response
One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.
Aug 16, 2007 - 4:00:00 AM
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Latest Research
New study shows promise in reducing surgical risks associated with surgical bleeding
CHICAGO (August 10, 2007) – Surgeons may have a new patient safety tool to stop moderate surgical bleeding without some of the concerns associated with the current standard blood-clotting treatment. New research published in the August issue of the Journal of the American College of Surgeons shows that recombinant human thrombin (rhThrombin) reduces the risk of surgical complications associated with the use of plasma-derived bovine thrombin (bThrombin), which is currently the only commercially available stand-alone thrombin used to improve clotting during surgical procedures and stop bleeding.
Aug 10, 2007 - 4:00:00 AM
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Latest Research
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
RICHMOND, Va. (Aug. 6, 2007) – Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.
Aug 6, 2007 - 4:00:00 AM
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Latest Research
Study shows radiofrequency ablation highly effective in treating kidney tumors
The patients underwent CT-guided radiofrequency ablation (RFA) at Wake Forest Baptist for kidney tumors ranging in size from 0.6 cm to 8.8 cm. A total of 125 tumors in 104 patients were treated over the period 2000 to 2006. In all of the patients, a biopsy had confirmed the presence of renal cell carcinomas (RCC), a common type of renal malignancy.
Aug 1, 2007 - 4:00:00 AM
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Latest Research
Scientists find why red beans and rice can be nauseating
People cry foul when fowl is undercooked, but what about red beans and rice
Aug 1, 2007 - 4:00:00 AM
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Latest Research
Penn researchers discover pathway that eliminates genetic defects in red blood cells
PHILADELPHIA – Researchers at the University of Pennsylvania School of Medicine have discovered a unique molecular pathway that detects and selectively eliminates defective messenger RNAs from red blood cells. Other such pathways – known as surveillance pathways – operate in a more general way, in many cell types. Knowing how this specific surveillance system works can help researchers better understand hereditary diseases, in this case, thalassemia, a form of anemia, which is the most common genetic disorder worldwide.
Aug 1, 2007 - 4:00:00 AM
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Latest Research
Aggressive therapy best for certain AML patients
COLUMBUS , Ohio – A new study suggests that acute leukemia patients whose cancer cells show a genetic change that usually predicts a swift return of the disease following remission may remain disease-free longer when given aggressive therapy.
Aug 1, 2007 - 4:00:00 AM
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Latest Research
First case of successful ovarian tissue transplantation between two, nonidentical sisters
A woman, whose ovaries had failed due to damage caused by chemotherapy and radiotherapy, has received a successful ovarian transplant from her genetically non-identical sister. The transplant restored her ovarian function, she started to menstruate and, after a year, doctors were able to recover two mature oocytes from her ovaries and fertilise them to produce two embryos.
Aug 1, 2007 - 4:00:00 AM
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Latest Research
Promising treatment target found in Hodgkin lymphoma
BOSTON--Dana-Farber Cancer Institute scientists have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. Based on this finding, the researchers are now investigating targeted therapies to disable this molecular bodyguard and boost a patient's ability to fight the blood cancer.
Jul 30, 2007 - 4:00:00 AM
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Latest Research
UB scientist discovers novel iron-copper alliance
BUFFALO, N.Y. -- Iron is the workhorse of trace minerals. An essential component of red blood cells, disruption of iron levels in the body will result in a myriad of serious conditions, and life cannot be sustained without it. In novel research, investigators at the University at Buffalo’s School of Public Health and Health Professions, have learned that iron is only one half of an all-important duo of trace minerals -- the other being copper -- that work in tandem to maintain proper iron balance, or homeostasis. It appears the workhorse has a helper. James F. Collins, Ph.D., UB assistant professor of exercise and nutrition sciences and biochemistry, discovered that when iron-absorption by cells lining the small intestine decreases during iron-deficient states, copper absorption increases. Collins now is exploring the relationship between these two trace minerals through a $1.38 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The work will be carried out using established models of intestinal iron absorption in humans, including iron and iron/copper-deficient rodents and cultured intestinal epithelial cells. “This project is intended to test the overall hypothesis that increased copper transport during iron-deficiency is critical to enhance certain aspects of intestinal iron absorption,” said Collins. “Iron or copper deficiency causes anemia, and abnormal intestinal iron transport is associated with several common human pathologies, including anemia of chronic disease (ACD) and hereditary hemochromatosis (HH), different forms of which result from several common genetic defects.” HH is an inherited metabolic disorder characterized by abnormally high absorption of dietary iron, which is deposited in body tissues and organs, where it may become toxic. ACD is a blood disorder caused by low body iron levels resulting from any medical condition that affects the production and lifespan of red blood cells, such as chronic infection, chronic immune activation resulting in inflammation, or malignancy.
Jul 23, 2007 - 4:00:00 AM
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Latest Research
Effects of aging in stem cells
There is little disagreement that the body’s maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why. Stem cells combat the aging process by replenishing old or damaged cells—particularly in the skin, gut, and blood—with a fresh supply to maintain and repair tissue. Unfortunately, new evidence published in the open-access journal PLoS Biology suggests that this regenerative capacity also declines with age as stem cells acquire functional defects.
Jul 23, 2007 - 4:00:00 AM
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Latest Research
Computers pass dosage test for thrombosis drugs
The largest ever study into the administration of blood thinning drugs like Warfarin has concluded that dosages calculated by computer are at least as safe and reliable as those provided by trained medical professionals.
Jul 19, 2007 - 4:00:00 AM
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Latest Research
Enzyme eliminated by cancer cells holds promise for cancer treatment
An enzyme that cancer cells eliminate, apparently so they can keep proliferating, may hold clues to more targeted, effective cancer treatment, scientists say.
Jul 18, 2007 - 4:00:00 AM
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Latest Research
Bak protein sets stressed cells on suicide path, researchers show
When a cell is seriously stressed, say by a heart attack, stroke or cancer, a protein called Bak just may set it up for suicide, researchers have found.
Jul 12, 2007 - 4:00:00 AM
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Latest Research
Method to prevent hemorrhagic complications of thrombolytic therapy of blood clots is discovered
A novel method to prevent hemorrhagic complications of thrombolytic therapy of blood clots is discovered.
Jul 2, 2007 - 4:00:00 AM
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Latest Research
Community Oncology explores pitched debate over anemia-fighting drugs
The June issue of Elsevier’s Community Oncology takes an in-depth look at the charge that ESAs, generally considered vital to cancer patients’ quality of life, are overprescribed for profit. Scientists, oncologists, and critics of oncologists are in a heated debate now over the use of ESAs, or erythropoiesis-stimulating agents—drugs that fight anemia by boosting levels of oxygen-carrying red blood cells and the protein hemoglobin.
Jun 26, 2007 - 4:00:00 AM
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Latest Research
A faster way to recover from chemotherapy and marrow transplant
Researchers at ChildrenÂ’s Hospital Boston report finding a new way to increase stem cells in blood, suggesting a possible treatment to help patients who undergo chemotherapy or bone marrow transplant for leukemia and other cancers recover their immune function more quickly. In the June 21 issue of Nature, they demonstrate that a stable analog of prostaglandin can enhance the blood-forming system, both during embryonic development and after itÂ’s been damaged.
Jun 20, 2007 - 4:00:00 AM
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Latest Research
Pre-cancerous blood diseases can be products of their environment
When blood-forming stem cells misbehave, causing pre-cancerous conditions that can sometimes even progress to leukemia, the problem might not always lie with them. Rather, two studies in the June 15 issue of the journal Cell, published by Cell Press, reveal that a bad environment might be to blame.
Jun 14, 2007 - 4:00:00 AM
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Latest Research
University of Pittsburgh researchers culture blood-forming stem cells from human fat tissue
TORONTO, June 14 – Researchers at the University of Pittsburgh School of Medicine have successfully isolated and cultured human hematopoietic stem cells from fat, or adipose, tissue, suggesting that they have found another important source of cells for reconstituting the bone marrow of patients undergoing intensive radiation therapy for blood cancers. They are presenting this ground-breaking research at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) North American Chapter meeting being held June 13 to 16 at the Westin Harbor Castle conference center in Toronto.
Jun 14, 2007 - 4:00:00 AM
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Latest Research
Red cells count: Study shows pre-op levels affect post-op outcomes
PROVIDENCE, R.I. [Brown University] — Men over 65 with even slightly abnormal red blood cell counts – either too low or too high – are at greater risk of post-operative death or car-diac events following a major non-cardiac surgery, according to a new study by researchers at the Providence Veterans Affairs Medical Center and The Warren Alpert Medical School of Brown University.
Jun 12, 2007 - 4:00:00 AM
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Latest Research
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Haematology
Dasatinib-high early response rate as first treatment for chronic myelogenous leukemia
An established second-line drug for chronic myelogenous leukemia has high response rates when given to newly diagnosed patients as their first therapy for the disease, according to early results from a Phase II clinical trial at The University of Texas M. D. Anderson Cancer Center.
Jun 3, 2007 - 2:03:55 AM
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Latest Research
World first medical treatment announced by researchers
Researchers at Queen Mary University London and the University of Leicester and have today (Friday June 1) announced a potential breakthrough in the treatment of a rare but devastating medical condition that can affect children and young people.
Jun 1, 2007 - 4:00:00 AM
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Latest Research
Researchers discover inherited mutation for leukemia
COLUMBUS , Ohio – Researchers have discovered the first inherited gene mutation that increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease.
May 31, 2007 - 4:00:00 AM
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Latest Research
Clinical guidelines for blood conservation during cardiac procedures developed
RICHMOND, Va. (May 16, 2007) – A team of medical experts led by a Virginia Commonwealth University anesthesiologist and a thoracic surgeon from the University of Kentucky has established a set of clinical guidelines to help physicians decrease the need for blood transfusions in high-risk patients during cardiac operations.
May 16, 2007 - 4:00:00 AM
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Latest Research
Cause of gender differences in blood pressure, kidney damage under study
While men and women both get high blood pressure and related kidney disease, the path to get there is shorter, steeper and just different for men, researchers say.
May 2, 2007 - 4:00:00 AM
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Latest Research
Cancer scientists create 'human' leukemia process to map how disease begins, progresses
(Toronto, Canada – April 26, 2007) -- Cancer researchers led by Dr. John Dick at Ontario Cancer Institute (OCI) have developed a method to convert normal human blood cells into human leukemia stem cells. The converted cells, when transplanted into special mice that permit the growth of human cells, can replicate the entire disease process from the very moment it begins. The findings are published in the journal Science.
Apr 26, 2007 - 4:00:00 AM
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Latest Research
Discovery of an HIV inhibitor in human blood points to new drug class
A new study has pinpointed a natural ingredient of human blood that effectively blocks HIV-1, the virus predominantly responsible for human AIDS, from infecting immune cells and multiplying. The virus blocker might play a role in the progression of HIV to full-blown AIDS and—because it works in a different way than existing antiretroviral inhibitors—could lead to the development of another class of drugs in the fight against the pandemic disease, researchers reported in the April 20, 2007 issue of the journal Cell, a publication of Cell Press.
Apr 19, 2007 - 4:00:00 AM
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Latest Research
Geisinger launches extensive study on obesity and related liver problem
DANVILLE, PA. - Relying on one of the largest collections of liver tissue samples ever acquired by a single organization, Geisinger Health System researchers have embarked on a massive study of one of the fastest growing liver problems.
Apr 16, 2007 - 4:00:00 AM
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Latest Research
Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer
Researchers at Columbia UniversityÂ’s Mailman School of Public Health have discovered a means for early detection of liver cancer. Using DNA isolated from serum samples as a baseline biomarker, the scientists examined changes in certain tumor suppressor genes that have been associated with the development of liver carcinomas. This is the first study to prospectively examine potential biomarkers for early detection of liver cancer in high-risk populations, including those with chronic hepatitis B and C virus infections.
Apr 15, 2007 - 4:00:00 AM
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Latest Research
Major gene study uncovers secrets of leukemia
Investigators at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children. The discovery not only suggests novel methods for treating pediatric ALL, but also provides a roadmap for the identification of unsuspected mutations in adult cancers.
Mar 7, 2007 - 5:00:00 AM
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Latest Research
Leukemia drug turns mini-molecules up, cancer genes down
COLUMBUS , Ohio – New research shows that a form of vitamin A used to treat acute promyelocytic leukemia induces changes in an unusual class of small molecules called microRNAs (miRNAs) in the leukemic cells.
Mar 1, 2007 - 5:00:00 AM
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Latest Research
Putting an old drug to a new use
We all know that iron deficiencies are dangerous, but also too much iron is bad for our health. Our body stores excess iron in various tissues, where it can lead to organ failure and even death if not treated before irreversible damage has occurred. Researchers from the Innsbruck Medical University, the University of Heidelberg, Germany, and the European Molecular Biology Laboratory (EMBL) now made a surprising discovery that may lead to new therapeutic approaches to treating such disorders. In this week's online issue of the journal Nature Medicine they report that a compound that was frequently used to treat high blood pressure can reverse iron overload in mouse models and has the potential to treat similar conditions in humans.
Feb 12, 2007 - 5:00:00 AM
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Latest Research
New blood thinner studied for patients with leg and lung clots
A new oral blood thinner is being compared to an old standby to see if it works as well and is easier to manage long term, researchers say.
Feb 12, 2007 - 5:00:00 AM
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Latest Research
Study finds endoscopic brain surgery pioneered in Pittsburgh effective in children with tumors
PITTSBURGH – Feb. 8, 2007 -- A first-of-its-kind study published in the February issue of the Journal of Neurosurgery: Pediatrics suggests endoscopic brain surgery, pioneered by surgeons at the University of Pittsburgh Medical Center, has the potential to be safer and often more effective than conventional surgery in children with life-threatening conditions.
Feb 8, 2007 - 5:00:00 AM
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Latest Research
Gene knockouts reveal FoxOs' vital functions in cancer defense, health of stem cells
BOSTON—In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.
Jan 25, 2007 - 5:00:00 AM
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Latest Research
Einstein's tea leaves inspire new blood separation technique
Scientists at Monash University in Australia have developed a process for rapidly and efficiently separating blood plasma at the microscopic level without any moving parts, potentially allowing doctors to do blood tests without sending samples to a laboratory. The new method uses the same principle that causes tea leaves to accumulate at the center of the bottom in a stirred teacup, a phenomenon first explained by Einstein in the 1920s.
Jan 16, 2007 - 5:00:00 AM
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Latest Research
Role for proteomics in identifying hematologic malignancies
BOSTON – Scientists have identified a set of biomarkers that could help clinicians identify a group of hematologic malignancies known as myelodysplastic syndromes (MDS), which affect approximately 300,000 individuals worldwide and often progress to acute myeloid leukemia.
Jan 11, 2007 - 5:00:00 AM
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Latest Research
Inflammatory genes linked to salt-sensitive hypertension
One key to your high blood pressure might just be your inflammatory genes.
Dec 27, 2006 - 5:00:00 AM
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Latest Research
Dengue and other hemorrhagic fevers: Towards a first potential treatment
Globally, 60 to 100 million people are hit by Dengue, a viral disease transmitted by mosquitoes of the genus Aedes. The most severe form of this disease, which causes blood loss, can lead to a fatal shock-like state (Dengue Shock Syndrome) with or without associated haemorrhage, and is currently increasing in tropical countries. The pathological mechanisms of Dengue are still unknown and it has not been possible to produce any treatment or vaccine. The only current prevention method is vector control.
Dec 22, 2006 - 5:00:00 AM
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Latest Research
How blood flow dictates gene expression
(PHILADELPHIA) -- Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic development a transcription factor called Klf2, which resides in cells that line blood vessels, is activated by rapid, pulsed blood flow, as reported in the December issue of Developmental Cell. Understanding Klf2's role in blood vessel and muscle biology could help with fighting atherosclerosis.
Dec 20, 2006 - 5:00:00 AM
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Latest Research
Blood transfusions raise heart patients' infection and death risk -- especially women
ANN ARBOR, Mich. -- Blood transfusions save the lives of millions of heart surgery patients and others each year. But a new study suggests that patients who receive transfusions during heart bypass surgery have a higher risk of developing potentially dangerous infections, and dying, after their operation.
Dec 19, 2006 - 5:00:00 AM
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Latest Research
MCG joins study of best treatment approach for narrowed kidney arteries
Whether reopening narrowed kidney arteries benefits patients is a $1.7 billion question a North American study hopes to answer.
Dec 19, 2006 - 5:00:00 AM
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Latest Research
Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
Unless the donor is an identical twin, patients undergoing bone-marrow transplant (also known as hematopoietic stem cell transplant, or HSCT) must first receive powerful chemotherapy drugs to wipe out their immune system and prevent their bodies from rejecting the donated cells. Research from ChildrenÂ’s Hospital Boston and the Dana-Farber Cancer Institute has helped demonstrate that this punishing regimen increases the risk of graft-versus-host disease (GVHD), in which the donorÂ’s cells mount an immune response against the patient. But the most recent findings also suggest that the risk for GVHD can be reduced by replacing a natural antibiotic protein, known as bactericidal/permeability increasing protein (BPI), which is depleted when patients undergo chemotherapy.
Dec 11, 2006 - 5:00:00 AM
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Latest Research
Sticky proteins provide new insight into drug action
How drugs such as adrenalin do primarily one thing – in this case, increase the heart rate – now makes more sense to scientists.
Nov 14, 2006 - 5:00:00 AM
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Latest Research
Should patients undergoing surgery get ASA?
Hamilton, ON - (Monday, Oct. 23, 2003) -- A national survey of Canadian surgeons by researchers at McMaster University found little consistency in their use of the blood thinner ASA in patients undergoing non-cardiac surgery.
Oct 23, 2006 - 4:00:00 AM
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Latest Research
Pall system to detect blood bacteria given CE mark
East Hills, NY (September 5, 2006) -- Pall Corporation (NYSE: PLL) announced the CE marking of its eBDS System to detect bacterial contamination of red blood cells, the most widely transfused blood component. The Pall eBDS is a highly sensitive culture-based test routinely used by blood centers to detect bacterial contamination of platelets, the leading infectious cause of sickness and death from a transfusion. Results of a new study presented at the International Society of Blood Transfusion (ISBT) 2006 Congress show the efficacy of the system in also detecting bacteria that are commonly found as contaminants of red blood cells.
Sep 5, 2006 - 4:00:00 AM
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