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Last Updated: Feb 6, 2010 - 1:05:06 PM |
Latest Research
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Gastroenterology
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Inflammatory Bowel Disease
Demographic profile suggests environmental role in etiology of Crohn's Disease
A research team from the United Kingdom determined the hospitalized prevalence of severe IBD and subsequent 5-year mortality in Wales, and investigated associations between severe IBD and social deprivation, distance travelled to hospital, and other socio-demographic characteristics.
Feb 6, 2010 - 12:58:24 PM
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Latest Research
A novel and simple formula to predict treatment success in chronic hepatitis C
The likelihood of treatment success of 48 wk peg-interferon (PEG-IFN) plus ribavirin (RBV) therapy for chronic hepatitis C may be predicted by viral kinetics on therapy. In particular, recent studies have shown that sustained virological response (SVR) can be predicted by a rapid virological response (RVR), and an early virological response (EVR). Nevertheless, the current dosing regimens could potentially under-treat some patients and additional measurements of viral response is needed to facilitate individualization of therapy. Among predictive factors already reported, many are not readily available from daily clinical assessment, because they require genomic analyses and/or advanced experimental methods. The prediction with simply available data may be useful.
Jan 14, 2010 - 4:59:36 AM
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Latest Research
Fat in the liver -- not the belly -- is a better marker for disease risk
New findings from nutrition researchers at Washington University School of Medicine in St. Louis suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver.
Aug 24, 2009 - 3:59:36 AM
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Latest Research
Sequential TACE and cryosurgery can improve survival times for patients with HCC?
Hepatocellular carcinoma (HCC)--a liver cancer--is recognized as one of the most common cancers in the world that disproportionately affects Southeast Asians and Africans. While there are therapies that possibly provide a cure, surgical removal and liver transplantation are invasive and radical options. However, even these approaches only benefit a small proportion of the total number HCC patients. Cryosurgery is a minimally invasive technique of using extreme low temperatures to freeze and kill tumors, improve patient' survival times, and reduce surgical complications. Cryosurgery can be potentially applied to any surgery for solid organ cancers where conventional surgery would otherwise be used to remove undesirable tissue. It is anticipated that in the near future, cryosurgery will increasingly replace the use of traditional techniques of ablation.
Aug 11, 2009 - 3:59:36 AM
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Latest Research
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively referred to as IBD.
Jun 2, 2009 - 3:59:36 AM
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Latest Research
No longer afraid to be a bridesmaid or travel with the boss
CHICAGO --- One of Laurie Keefer's patients was afraid to be a bridesmaid in a friend's wedding, others worried about traveling with the boss or even going to parties in peoples' homes.
May 13, 2009 - 3:59:36 AM
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Latest Research
UIC researchers measure health effects of Chicago's waterways
Researchers at the University of Illinois at Chicago School of Public Health are conducting a study to determine the health effects associated with recreational activities such as boating, canoeing, kayaking and fishing on Chicago's waterways.
Mar 23, 2009 - 3:59:36 AM
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Latest Research
Putting a name to the fluke
In a world first, a UQ researcher has developed a non-invasive screening method for potentially fatal liver and intestinal flukes plaguing the lives of an estimated 9 million people throughout southeast Asia.
Feb 11, 2009 - 4:59:36 AM
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Latest Research
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Gastroenterology
14.6% of patients with Iron deficiency anaemia of obscure origin have gluten sensitive enteropathy (GSE
A research team led by Prof. Reza Malekzadeh studied the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. Their findings will be published on December 28, 2008 in the World Journal of Gastroenterology.
Dec 31, 2008 - 8:13:03 AM
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Latest Research
Novel IBS treatment developed at UB garners $8.5 million for seven-year clinical trial
BUFFALO, N.Y. -- Irritable bowel syndrome is a chronic, debilitating disorder affecting 25 million people in the U.S -- 14-24 percent of women and 5-19 percent of men.
Nov 13, 2008 - 4:59:37 AM
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Latest Research
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Gastroenterology
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Liver
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Hepatitis
Factors for developing IPF in Hepatitis C patients
There is little or no information on the yearly cumulative incidence and risk factors on the development rate of Idiopathic pulmonary fibrosis in patients with HCV.A research team led by Yasuji Arase from Toranomon Hospital of Japan addresses this, and the study will be published on October 14, 2008 in the World Journal of Gastroenterology.
Oct 23, 2008 - 2:12:21 PM
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Latest Research
Children's Hospital of Pittsburgh of UPMC scientific director elected to Institute of Medicine
David H. Perlmutter, MD, scientific director and physician-in-chief at Children's Hospital of Pittsburgh of UPMC, has been elected to the prestigious Institute of Medicine (IOM).
Oct 13, 2008 - 3:59:37 AM
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Latest Research
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Gastroenterology
Endoscopy not needed in asymptomatic children after caustic ingestion
A new study from researchers in Italy reports that endoscopy may not be necessary in children who show no symptoms after a caustic ingestion. The results demonstrated that the incidence of severe abnormalities of the esophagus in children without any early symptoms is very low and an endoscopy could be avoided.
Sep 26, 2008 - 11:52:06 PM
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Latest Research
How to prevent liver damage induced by anti-tuberculosis treatment?
About one third of the world's population has latent tuberculosis and roughly 9 million cases of active tuberculosis emerge annually resulting in 2-3million deaths. Most new cases occur in the most populated nations like India and China. Combination chemotherapy containing Isoniazid (INH), Rifampicin (RMP), Pyrazinamide (PZA) with or without ethambutol for initial 2 months followed by a continuation phase of 4-6 months of Isoniazid and Rifampicin is the preferred regimen for successful treatment and for preventing acquired resistance. Drug induced hepatotoxicity is a potentially serious adverse effect of antituberculosis (ATT) regimen. A higher risk of hepatotoxicity has been reported in Indian patients (up to 11.5%) than in their western counterpart (up to 4.3%). The only measure available for managing hepatotoxicity is stopping the offending agents, once there is an evidence of liver damage and reintroducing the same after normalization of liver enzymes. Preventive therapy of contacts causes severe hepatotoxicity more often than curative treatment of clinical tuberculosis. Search for non-toxic and highly effective new compounds for treating tuberculosis or an effective vaccine conferring sustained protective immunity have yet not seen the face of success.
Sep 19, 2008 - 3:59:37 AM
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Latest Research
String probes for devastating childhood digestive disease
A swallowed string may someday replace the invasive, uncomfortable endoscope now used to diagnose a devastating childhood disease of the esophagus.
Jul 30, 2008 - 3:59:37 AM
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Latest Research
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Gastroenterology
Integrins act as receptors to Rotavirus
Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhoea. In a report online in the Proceedings of the National Academy of Sciences, Estes and her colleagues describe two receptors for the enterotoxin, both of them integrins.
Jun 30, 2008 - 9:07:20 AM
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Latest Research
NCI grant launches clinical trials for colon cancer screening
EVANSTON, Ill. --- A Northwestern University biomedical engineer who has developed optical technology shown to be effective for the early detection of colon cancer has received a $7.5 million grant over five years from the National Cancer Institute to further study an instrument that potentially could become a routine colon cancer screening test and to launch large-scale clinical trials.
Jun 25, 2008 - 3:59:37 AM
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Latest Research
'Addicted' cells provide early cancer diagnosis
Scientists at the Institute of Food Research have detected subtle changes that may make the bowel more vulnerable to the development of tumours.
Jun 10, 2008 - 3:59:37 AM
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Latest Research
Weizmann Institute scientists develop a new approach to treating autoimmune disease
In autoimmune diseases, the immune system turns against the body's own tissues and organs, wreaking havoc and destruction for no apparent reason. Partly because the origins of these diseases are so obscure, no effective treatment exists, and the suffering they inflict is enormous. Now Weizmann Institute scientists have developed a method that in the future may make it possible to treat autoimmune diseases effectively without necessarily knowing their exact cause. Their approach is equivalent to sending a police force to suppress a riot without seeking out the individuals who instigated the unrest.
Jun 2, 2008 - 3:59:37 AM
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Latest Research
A better method is found for the treatment of patients with portal hypertension
Bleeding from ruptured esophageal varices is the main complication of portal hypertension and a major cause of death. About one-third of variceal bleeding episodes are fatal while 70% of survivors re-bleed within a year. Propranolol, the drug of choice for primary prevention of variceal bleeding, has been found to be effective in 45% of patients who have never bled, and in only 40% of patients who have had a bleeding episode before. Thus, this drug does not protect a significant number of patients and combination therapy has been advocated as a result. Various drug combinations have been tried, most commonly propranolol with isosorbide mononitrate. However, the problem with combination therapy is an increased incidence of side effects, poor tolerability and lack of compliance. The search for an ideal drug combination that is effective, relatively free from side effects and easy to administer, has been elusive.
May 20, 2008 - 3:59:37 AM
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Latest Research
Synergistic growth inhibitory effect of herbal extracts against HCC and lung cancer cells
Several herbs with diversified pharmacological properties are known to be rich sources of chemical constituents that may have potential for the treatment of several human cancers. Data from the Department of Preclinical Science, Faculty of Medicine, Thammasat University, demonstrates that the growth inhibitory activity of doxorubicin or cisplatin, as single agents, may be modified in combination with emblic myrobalan or belleric myrobalan extracts and may be synergistically enhanced in some cases.
Apr 30, 2008 - 3:59:37 AM
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Healthcare
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India Healthcare
India unveils zinc tablet to control diarrhoea
New Delhi, April 7 - India Monday unveiled a zinc dispersible tablet to control diarrhoea, a disease that kills nearly 500,000 children in the country every year.
Apr 7, 2008 - 7:54:57 PM
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Latest Research
What change does prokineticin 2/Bv8 have in human hepatocellular carcinoma?
Liver hepatocarcinoma is a highly vascularized cancer, and more and more research is focused on the molecules controlling angiogenesis. In 2001, two novel peptides, known as prokineticin 1/EG-VEGF (PK1/EG-VEGF) and prokineticin 2/Bv8 (PK2/Bv8), were identified, as having potent angiogenic activities. The angiogenic potential of these two peptides during human hepatocellular carcinoma progression was evaluated. These findings show, that only, PK2/Bv8 is expressed in liver and -- surprisingly -- that its expression decreases during hepatocellular carcinoma. Furthermore, these results show that PK2/Bv8 expression is restricted specifically to liver resident macrophages, thus suggesting a role in Kuppfer cell physiology.
Mar 18, 2008 - 3:59:37 AM
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Latest Research
Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Heavier alcohol consumption increases the risk of ESCC. There are synergetic interactions among alcohol drinking and ALDH2, ADH1B, CYP2E1 genotypes. The risk of ESCC in moderate-to-heavy drinkers, ALDH2 (1/2) combined with the ADH1B (1/1) genotype; ALDH2 (1/2) combined with the CYP2E1 (c1/c1) genotype; leads to synergetic interactions, higher than drinkers with ALDH2 (1/1) + ADH1B (1/2 + 2/2); ALDH2 (1/1) + CYP2E1 (c1/c2 + c2/c2).
Mar 13, 2008 - 3:59:37 AM
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Latest Research
Scientists successfully treat new mouse model of inflammatory bowel disease
March 6, 2008 -- Researchers trying to improve cancer immune therapy have made an unexpected find: They've produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that afflict approximately 1.4 million Americans with abdominal pain, constipation and diarrhea.
Mar 6, 2008 - 4:59:37 AM
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Latest Research
Type 2 diabetes may be caused by intestinal dysfunction
NEW YORK (March 5, 2008) -- Growing evidence shows that surgery may effectively cure Type 2 diabetes -- an approach that not only may change the way the disease is treated, but that introduces a new way of thinking about diabetes.
Mar 5, 2008 - 4:59:37 AM
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Latest Research
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Gastroenterology
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Inflammatory Bowel Disease
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Crohn's Disease
Crohn's disease or gastrointestinal endometriosis?
Crohn's disease may mimic gastrointestinal endometriosis in its clinical presentation.A case report published on January 7, 2008 in the World Journal of Gastroenterology describes such a patient.
Feb 22, 2008 - 8:02:46 AM
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Latest Research
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Gastroenterology
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Liver
small intestinal bacteria overgrowthplays a role in nonalcoholic fatty liver disease?
An article recently published in the January 14 issue of the World Journal of Gastroenterology has great significance for NASH. This article will undoubtedly bring about new pathogenesis and treatment of NASH.
Feb 22, 2008 - 7:08:44 AM
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Latest Research
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Gastroenterology
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Inflammatory Bowel Disease
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Crohn's Disease
Alternative strategy better for Crohn's Disease
An international research study, published in The Lancet, has thrown into question the current method of treating Crohn’s disease – opening the door to a safer and more effective treatment option for sufferers of the chronic disease.
Feb 22, 2008 - 6:52:36 AM
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Latest Research
May inflammatory bowel disease mimic gynecological disorders in its clinical presentation
Endometriosis is a condition of unknown etiology in which endometrial tissue occurs at extra-uterine sites, including ovaries, fallopian tubes, and gastrointestinal tract. It usually occurs between 30 and 40 years of age. Four to 17% of menstruating women develop endometriosis. When the disease involves the small bowel, it usually has a benign course, but in rare circumstances, it may present as abdominal emergency. Invasive bowel endometriosis can present as bowel obstruction. The major cause of obstruction is stricture formation and adhesions, which occasionally mimic Crohn's disease or a malignancy in its clinical presentation.
Feb 22, 2008 - 4:59:37 AM
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Latest Research
Do patients with inflammatory bowel disease receive optimal care?
Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal disease. The disease has a relatively higher morbidity in young adults, in whom growth, education, employment and wellbeing all are adversely influenced. A number of guidelines for management of inflammatory bowel disease are available for bringing evidence-based medicine into full play to improve IBD patient care. What about the actual quality of care for patients with IBD in China?
Feb 22, 2008 - 4:59:37 AM
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Latest Research
University of Sydney researchers find new evidence linking kava to liver damage
In recent years, serious concerns about the dangers of kava and the effects on the liver have resulted in regulatory agencies, such as the US Food and Drug Administration and Australia's Therapeutic Goods Administration, banning or restricting the sale of kava and kava products.
Feb 22, 2008 - 4:59:37 AM
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Latest Research
A strange case of upper obstructive syndrome
Aorto-duodenal fistulae (ADF) are the most frequent aorto-enteric fistulae (80%) and the most frequent presenting sign of ADF is upper gastrointestinal bleeding (UGI). A 59-year-old male patient, who underwent an aortic-bi-femoral bypass five years ago, was admitted to the Emergency Room after five days of persistent occlusive syndrome with dyspepsia and biliary vomiting. Computed tomography (CT) scan showed in the third duodenal segment the presence of an area with the characteristics of inflammatory tissue, including air bubbles between the duodenum and aortic-bi-femoral prosthesis adherent to the third duodenal portion (pcomma signq) (Figure 1). Microbiological cultures and scintigraphy were unremarkable. Esophago-gastro-duodenoscopy showed the aortic prosthesis crossing the third segment of duodenal wall occluding the intestinal lumen (Figure 2). At laparotomy, after viscerolisis, the prosthesis was detached from duodenal wall and the intestine failed to close transversely (Figure 3). To protect the intestinal wall, a pediculated fragment of the greater omentum was placed between the duodenum and aortic bypass. Furthermore, a gastrojejunal Roux anastomosis was employed. The prosthesis was not changed because there were no local or systemic signs of infection. The post-operative course was uneventful.
Feb 22, 2008 - 4:59:37 AM
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Latest Research
Scientists using laser light to detect potential diseases via breath samples, says new study
By blasting a person's breath with laser light, scientists from the National Institute of Standards and Technology and the University of Colorado at Boulder have shown that they can detect molecules that may be markers for diseases like asthma or cancer.
Feb 18, 2008 - 4:59:37 AM
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Latest Research
Europe's most common genetic disease is a liver disorder
Much less widely known than the dangerous consequences of iron deficiencies is the fact that too much iron can also cause problems. The exact origin of the genetic iron overload disorder hereditary hemochromatosis (HH) has remained elusive. In a joint effort, researchers from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany, have now discovered that HH is a liver disease. They report in the current issue of Cell Metabolism that the disorder develops when a crucial gene is lacking in liver cells.
Feb 6, 2008 - 8:54:37 PM
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Latest Research
Camera in a pill offers cheaper, easier window on your insides
What if swallowing a pill with a camera could detect the earliest signs of cancer? The tiny camera is designed to take high-quality, color pictures in confined spaces. Such a device could find warning signs of esophageal cancer, the fastest growing cancer in the United States.
Jan 24, 2008 - 4:59:37 AM
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Latest Research
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Gastroenterology
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Liver
Ginsenosaide Rb1 (R1)- chinese medicine ingredient found to protect liver
A study by Han Jing-Yan et al discovered Ginsenosaide Rb1 (R1) is able to prevent hepatic microcirculatory disturbance and subsequent liver injury in mice induced by intestine ischemia and reperfusion (I/R). R1 is one of the major effective ingredients of Panax notoginseng (PN), a traditional Chinese herb medicine frequently included in various compound Chinese medicines for treatment of liver injury and numerous other diseases in China and other Asian countries.
Jan 16, 2008 - 1:48:08 PM
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Latest Research
Indian medicinal plant Acanthus ilicifolius may combat liver cancer
Liver cancer is the fifth most common cancer in the world with a poor prognosis. About three quarters of the cases of liver cancer are found in Southeast Asia, including China, Hong Kong, Taiwan, Korea, India, and Japan. The frequency of liver cancer in Southeast Asia and sub-Saharan Africa is greater than 20 cases per 100,000 population. Moreover, recent data show the frequency of liver cancer in the U.S. overall is rising.
Jan 16, 2008 - 4:59:37 AM
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Latest Research
Eltrombopag effective for hepatitis C patients with low blood-platelet counts
NEW YORK (Dec. 28, 2007) -- For patients with hepatitis C, having a low blood platelet count is a frequent complication associated with advanced disease. This problem is compounded by the fact that standard antiviral treatment for the disease can further reduce platelet numbers to dangerously low levels, effectively denying these patients the treatment they urgently need. Now, research published in the New England Journal of Medicine finds that a new drug, eltrombopag, appears to significantly boost platelet counts, opening the door to effective treatment.
Dec 28, 2007 - 4:59:37 AM
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Latest Research
Breath test can discriminate between a bacterial overgrowth and IBS
The gastrointestinal (GI) tract is colonized by bacteria immediately after birth; Escherichia coli, Streptococci and Clostridi are the first bacteria harboured by the colon, followed by anaerobic Enterococci, Lattobacilli and Bacteroidi. These commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity; on the other hand, intestinal motility represents one of the major control systems of gut microflora, though the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bi-directional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth (SIBO).
Dec 19, 2007 - 4:59:37 AM
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Latest Research
Who is the arch-criminal in the development of hepatopulmonary syndrome?
The hepatopulmonary syndrome (HPS) develops when an arterial oxygenation deficiency occurs due to intra-pulmonary vascular dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with liver cirrhosis undergoing evaluation for orthotopic liver transplantation. Recent studies support that the presence of HPS significantly increases mortality in cirrhosis, particularly in those with decompensated liver disease.
Dec 19, 2007 - 4:59:37 AM
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Latest Research
Research reveals secrets of alcohol's effect on brain cells
NEW YORK (Dec. 7, 2007) -- Alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells, and new research from Weill Cornell Medical College in New York City sheds light on how that process occurs.
Dec 7, 2007 - 4:59:37 AM
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Latest Research
The most important candidate genes for pancreatic stone formation
Stone formation is an important feature of chronic pancreatitis, especially tropical calcific pancreatitis (TCP), where the stones are large in size, highly irregular in shape and cause enormous tissue destruction. The exact mechanism of stone formation is not well-understood. It is very important to understand the initial event so that stone formation can be controlled before it causes obstruction and damage to the pancreatic tissue. One such study was recently reported in the November 28 issue of the World Journal of Gastroenterology because of its significance in pancreatic diseases.
Nov 13, 2007 - 4:59:37 AM
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Latest Research
Antegrade bowel intussusception can cause recurrent, chronic postoperative intestinal obstruction
Several complications can be seen after pancreatic surgery, most notably bleeding, infections and anastomotic dehiscence. Bowel obstruction can also be seen due to internal hernias or anastomotic strictures. A more unusual etiology for bowel obstruction in this setting is intussusception.
Nov 13, 2007 - 4:59:37 AM
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Latest Research
Hepatitis C treatment reduces the virus but serious liver problems may progress
Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases in their liver enzymes, viral levels, and liver inflammation following treatment with long-term pegylated interferon. However, the treatment did not slow or prevent the progression of serious liver disease. These findings come from the clinical trial, Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) and were reported at the annual meeting of the American Association for the Study of Liver Disease in Boston on November 5, 2007. HALT-C is funded by the National Institutes of Health (NIH) with additional support from Hoffmann-La Roche Inc.
Nov 6, 2007 - 4:59:37 AM
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Latest Research
Endosonography-guided biliary drainage is useful in cases with failed endoscopic biliary stenting
The role of endosonography (ES) in digestive diseases is expanding gradually from diagnostic applications to therapeutic ones. The feasibility of ES-guided cholangiopancreatography was first reported by Harada et al. (pancreatography) and Wiersema et al. (cholangiography) in 1995 and 1996, respectively. Several reports on the application of ESBD for a therapeutic purpose have been published since 2001. However, there have been no reports as to the influence of this technique on the gut wall, the bile duct, and the intervening tissues. A research article published on November 7 issue 41 of World Journal of Gastroenterology addresses one answer to this question in a case report form.
Nov 2, 2007 - 3:59:37 AM
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Latest Research
24-week course of interferon-alpha therapy prolongs survival in patients hepatitis C virus
Patients with the hepatitis C virus (HCV) have a risk of frequent recurrence and deterioration of liver function, even after curative treatment for the primary hepatocellular carcinoma (HCC). This unfavorable prognosis is associated with a sustained HCV infection. Thus, both the prevention of HCC recurrence and the preservation of liver function are high priorities when trying to improve the prognosis of patients with HCV-related HCC. Antiviral therapy for chronic hepatitis C (HCV) after treatment for primary HCC is the essential factor required for an improved prognosis.
Nov 2, 2007 - 3:59:37 AM
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Latest Research
Does neural cell adhesion molecule-180 predict survival in colorectal cancer?
When a person learns they are suffering from cancer, the first question in their mind is always: How much time do I have? Unfortunately, this is a question to which the researchers have long been seeking an absolute answer. Tumor progression to local invasion and metastasis are the most relevant processes for prognosis, and predictive factors for survival are sometimes the only hope for cancer patients. Tumor suppressors and adhesion molecules represent one of the primary challenges in cancer therapy.
Nov 2, 2007 - 3:59:37 AM
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Latest Research
Exclusion of common bile duct stones prior to gallstone operations
CBDS occur in 7-20% of all patients undergoing a gallstone operation and may complicate the course of surgery. Although intraoperative x-ray investigation was routinely performed to diagnose CBDS in the pre-laparoscopic era, its use during the laparoscopic era has been debated. Consequently, other techniques for diagnosing CBDS have been introduced. For example, preoperative liver function test (LFT; s-bilirubin and s-ALP) results, if abnormal, might be diagnostic for CBDS. However, some patients might have normal LFT despite coexisting CBDS. Ultrasonography is the major diagnostic modality used to diagnose gallstones, but is less helpful for diagnosing CBDS. Computed tomography is rarely useful for diagnosing gallstones. Magnetic-resonance-cholangio-pancreatography (MRCP) has high specificity and sensitivity, with accuracy similar to that of ERCP (Endoscopic-Retrograde-Cholangio-Pancreatography), but its accuracy depends on the size and anatomical location of a gallstone. In addition, MRCP is not widely available, and unlike ERCP, does not allow the endoscopic extraction of stones. ERCP is the most common technique used for both the diagnosis and treatment of CBDS. It is, however, expensive, invasive, technically demanding and associated with small but significant morbidity.
Oct 30, 2007 - 3:59:37 AM
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Latest Research
Attenuation of NASH by stimulation of free fatty acid metabolism
Medically-complicated obesity is a societal problem that needs to be solved. Liver disease, specifically non-alcoholic steatohepatitis or NASH, is just one of the many complications of increased body weight. Treatment options for NASH are limited, and therefore there is an unmet need for pharmacologic treatment of this liver disease. A recent article in World Journal of Gastroenterology by Dr. Baski-Bey et al. offers a helping hand to potentially aid in abolishing the occurrence of NASH in the population. The article describes how administration of a constitutive androstane receptor (CAR) agonist (TCPOBOP) can induce genes involved in fatty acid microsomal omega-oxidation and beta-oxidation pathways, resulting in a reduction in the occurrence of NASH in mice fed the methionine choline deficient (MCD) diet. The MCD diet, when fed to rodents, rapidly produces hepatic steatosis and steatohepatitis by blocking fatty acid oxidation.
Oct 26, 2007 - 3:59:37 AM
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| Health |
Musculoskeletal problems ail computer workers
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Eating less may help you live longer
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IOM report on national vaccine plan
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You may damage knees if you're an exercise freak
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American adults receiving flu vaccine at about the same rate as in 2008, study finds
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Widowed people have higher mortality
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Anxious women more likely to have smaller babies
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UIC receives $1 million grant to study 'fat taxes,' diet, obesity
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Progress made on group B streptococcus vaccine
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Exercise addiction could prove fatal
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| | Healthcare |
Biotech industry hails tax sops in Indian budget
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Junior doctors in Madhya Pradesh call off strike
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25000 NRI Doctors Could Return to India from UK
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AIIMS to guide 40 medical colleges on drug reaction
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15 percent of Indian women below 50 are obese: Azad
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Mexico expects swine flu infections to peak at New Year
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Wipro unveils new application for remote healthcare
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Azad hikes funds for cancer control, treatment of poor
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Kerala medical colleges doctors suspend agitation
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Delhi records 280 cases of dengue
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| | Latest Research |
Belatacept may preserve renal function better than calcineurin inhibitors in kidney transplantation
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K-State professor finds link between low oxygen levels in body and cancer-aiding protein
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HHMI's Gilliam Fellowships aim to increase diversity in the sciences
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Saving lives one breath at a time
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Improvements needed in genomic test result discussions
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Occupational sunlight exposure and kidney cancer risk in men
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The life and death of online communities
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Deep sedimentation of acantharian cysts -- a reproductive strategy?
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Adele Boskey 2010 recipient of ORS/AOA award for lifetime contributions to orthopedics
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National Jewish Health receives grant to learn how families cope with food allergy
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| | Medical News |
Azad invites NRI investment in pharmaceuticals, medical education
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25000 NRI Doctors Could Return to India from UK
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Eat pistachio to lower blood sugar
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Stricter resident doctor duty hour required to prevent medical errors
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Chandigarh adult drinks 11 bottles a month
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Swine flu vaccine nearing development: Official
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India to be diabetes' world capital by 2025: Expert
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US may allow 5,000 more Indian doctors for residency training
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Scissors taken out from man's stomach after two years
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India's swine flu toll reaches 967, over 26,000 infected
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| | Special Topics |
'Primodial Soup' theory for origin of life rejected in paper
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Human species could have killed Neanderthal man
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History, geography also seem to shape our genome
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3,000 Kerala medical students to attend inter-college meet
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Tamil Nadu seeks to control deemed universities
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Spiders which eat together, stay together and multiply
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Anna Hazare - the keeper of the earth and human conscience
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Indian American scientist wins top IMO prize
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Artificial human sperm could make men redundant: experts
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Will autopsy on Benazir's body become necessary?
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