XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
  IBS
  Liver
   Hepatitis
  GERD
  Constipation
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

Liver Channel
subscribe to Liver newsletter

Latest Research : Gastroenterology : Liver

   DISCUSS   |   EMAIL   |   PRINT
TWEAK Induces Liver Progenitor Cell Proliferation
Aug 19, 2005, 13:51, Reviewed by: Dr.

The potential role for the TWEAK pathway in chronic human liver diseases that are accompanied by oval cell proliferation is suggested by data showing increased expression of the receptor for TWEAK in alcoholic cirrhosis and viral hepatitis.

 
Liver injury can occur as a result of alcohol toxicity, necrosis, or a host of other factors. When the liver is injured, it responds with progenitor cell (oval cell) proliferation in the remaining parts of the organ. The oval cells can become either liver cells or epithelial cells, and are vital for recovery from liver injury. But the regulation of oval cell expansion is not well understood.

In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Aniela Jakubowski and colleagues from Biogen report the discovery of a novel role for the TNF family member, TWEAK, as an inducer of oval cell proliferation in the liver. This is the first demonstration of a role for this cytokine in the regulation of liver progenitor cells.

Unlike other factors that can modulate the proliferation of oval cells, the researchers show that TWEAK acts selectively on oval cells with no effect on mature liver cells. They use three independent approaches: animals overexpressing TWEAK, adenoviral delivery of TWEAK, and TWEAK blocking antibodies in a model of oval cell hyperplasia.

The potential role for the TWEAK pathway in chronic human liver diseases that are accompanied by oval cell proliferation is suggested by data showing increased expression of the receptor for TWEAK in alcoholic cirrhosis and viral hepatitis. A better understanding of the molecular pathways regulating the progenitor cell response may lead to specific therapies for liver diseases.
 

- September 1 issue of the Journal of Clinical Investigation
 

PDF of this article at: https://www.the-jci.org/article.php?id=23486

 
Subscribe to Liver Newsletter
E-mail Address:

 

AUTHOR CONTACT:
Aniela Jakubowski
Biogen Idec Inc., Cambridge, MA USA
Phone: 617-679-6205; Fax: 617-679-3148; E-mail: [email protected]


Related Liver News

MR Elastography may help in early diagnosis of liver fibrosis
Why does prolonged IV feeding damage the liver?
Coffee may reduce risk of alcoholic cirrhosis
Chronic hepatitis in pediatric liver transplant patients
Nanoparticles may pose threat to hepatocytes
Vaccinating Infants of Hepatitis B Mothers Prevents Infection - Systematic Review
Need for treatment modification in older hepatitis C patients
Obese mice are more susceptible to liver abnormalities
TWEAK Induces Liver Progenitor Cell Proliferation
Therapy may not be necessary for asymptomatic autoimmune hepatitis


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us