||Last Updated: Nov 17th, 2006 - 22:35:04
Gene Expression Profiling Not Quite Perfected in Predicting Lung Cancer Prognosis
While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung cancer patients.
Nov 17, 2006, 13:31
Breast cancer chemotherapy may deterioration in cognitive function
A new study investigating the effects of chemotherapy on cognitive function in mice has confirmed what many cancer patients receiving treatment have often complained about – a decline in their memory and other cognitive functions, sometimes characterized as "chemobrain". The study, led by Dr. Gordon Winocur of the Baycrest Research Centre for Aging and the Brain, in collaboration with Drs. Ian Tannock and Janette Vardy of Princess Margaret Hospital, was conducted at Trent University. The findings are published in the September 2006 issue of Pharmacology, Biochemistry and Behavior (Vol. 85, Issue 1), which will be available online in the next week. The results were presented at a workshop held in conjunction with the 8th World Congress of Psycho-Oncology in Venice last week.
Oct 29, 2006, 21:32
I-ELCAP study: Lung cancer can be detected early with annual low-dose CT screening
Lung cancer can be detected at its very earliest stage in 85 percent of patients using annual low-dose CT screening, and when followed by prompt surgical removal, the 10-year survival rate is 92 percent. These results, to be reported in the October 26 New England Journal of Medicine, would dramatically decrease the number of deaths from lung cancer — the number one cause of cancer deaths among both men and women in the U.S.
Oct 26, 2006, 19:24
Genomic signatures to guide the use of chemotherapeutics
Scientists at Duke University's Institute for Genome Sciences & Policy have developed a panel of genomic tests that analyzes the unique molecular traits of a cancerous tumor and determines which chemotherapy will most aggressively attack that patient's cancer.
Oct 23, 2006, 18:59
Elderly Breast Cancer Patients May Be Under-Diagnosed And Under-Treated
Elderly patients with breast cancer who received care in a community hospital setting may have been under-diagnosed, under-staged and under-treated, according to a report in the October issue of Archives of Surgery, one of the JAMA/Archives journals. The number of older breast cancer patients has increased along with overall elderly population, according to background information in the article. About half of breast cancer patients are older than 65 years and 35 percent are older than 70; 77 percent of breast cancer deaths occur in women older than 55. Choosing the appropriate treatment for older patients is a challenge, because many have other serious illnesses in addition to their cancer that may threaten their health and shorten their lives. Questions remain about the best screening protocols for elderly women, as well. Some current guidelines suggest that women stop having mammograms at age 70, while others provide no upper limit.
Oct 17, 2006, 14:34
Listening to the sound of skin cancer
Researchers at the University of Missouri-Columbia can now detect the spread of skin cancer cells through the blood by literally listening to their sound. The unprecedented, minimally invasive technique causes melanoma cells to emit noise, and could let oncologists spot early signs of metastases -- as few as 10 cancer cells in a blood sample -- before they even settle in other organs.
Oct 17, 2006, 02:06
Tissue Geometry Plays Crucial Role in Breast Cell Invasion
Apropos of National Breast Cancer Awareness month, researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have created a first-of-its-kind model for studying how breast tissue is shaped and structured during development. The model may shed new light on how the misbehavior of only a few cells can facilitate metastatic invasion because it shows that the development of breast tissue, normal or abnormal, is controlled not only by genetics but also by geometry. Though created specifically for the study of breast tissue, this model should also be applicable to the study of tissue development in other organs as well.
Oct 13, 2006, 11:02
Regulatory Approval for New Cotara(R) Brain Cancer Clinical Trial
Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a biopharmaceutical company with a portfolio of innovative, clinical stage products for the treatment of cancer and hepatitis C virus infection, today announced that it has received regulatory approval in India for a new clinical trial of its lead tumor necrosis therapy (TNT) agent Cotara(R). The trial is designed to test the safety and efficacy of Cotara in patients with glioblastoma multiforme, a deadly form of brain cancer. Cotara is currently being studied in a multi-center U.S. glioblastoma trial. Previous studies using Cotara to treat brain cancer have produced encouraging results, and Peregrine expects that positive data from this trial in combination with data from the ongoing U.S. clinical trial should provide the foundation for planning the future development and commercialization of Cotara.
Oct 13, 2006, 01:17
CDK2/FOXO1 as drug target to Prevent Tumors
Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication. This knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science.
Oct 13, 2006, 01:11
Key to lung cancer chemotherapy resistance revealed
Scientists at Johns Hopkins have discovered how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer. Products made by a gene called NRF2 normally protect cells from environmental pollutants like cigarette smoke and diesel exhaust by absorbing the materials and pumping them out of the cell. Another gene called KEAP1 encodes products that stop this cleansing process. But lung cancer cells sabotage the expression of these same genes to block assault from chemotherapy drugs.
Oct 11, 2006, 05:36
Ethnic variations in hormone levels may cause differences in breast cancer risk
Researchers have known that a woman's natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern California (USC) has found that the natural levels of estrogens in post-menopausal women varies by ethnicity and race, and may explain the differences in the groups' breast cancer rates. The study appears in the October issue of Cancer Epidemiology, Biomarkers & Prevention.
Oct 10, 2006, 12:22
Aspirin also helps to fight cancer, new study shows
When looking for new weapons in the war on cancer, scientists should turn to their medicine cabinets for an age-old remedy--aspirin.
Oct 2, 2006, 17:26
Researchers set benchmarks for screening mammography
A recent study of medical audit data funded by the National Cancer Institute (NCI) revealed that community mammography screening results surpass performance recommendations across the United States. Approximately 188 mammography facilities nationwide contributed to the study of more than 1.1 million women, who underwent at least one screening mammography exam between 1996 and 2002. The findings are reported in the October issue of Radiology.
Sep 26, 2006, 23:10
Gene therapy study takes aim at prostate cancer
Researchers at Baylor College of Medicine (BCM) are hoping a new gene therapy that takes a gene called RTVP-1 directly into the prostate tumor will prove effective in preventing recurrence of the disease. The first phase of the study is designed to test the safety of the treatment and determine the proper dosage of gene, said Dr. Dov Kadmon, professor of urology at BCM. It will be carried out in the department of urology at BCM as well as at Ben Taub General Hospital, The Methodist Hospital and Michael E. DeBakey Veterans Affairs Medical Center.
Sep 26, 2006, 22:41
African-American women with uterine cancer have worse survival rates
African-American women with uterine cancer have worse survival rates than Caucasian women who received similar treatment even though they had similar prognostic factors, according to a new review of four clinical trials. Published in the November 1, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the review found significant racial disparities in survival and clinical presentation of advanced/recurrent endometrial cancer.
Sep 25, 2006, 18:43
Less than one third gastric cancer patients actually have adequate lymph node assessments
Most patients who undergo gastric cancer staging by lymph node sampling have inadequate assessments that compromise survival, according to a new study. Published in the November 1, 2006 issue of CANCER , a peer-reviewed journal of the American Cancer Society, the study reveals that less than one third of gastric cancer patients had adequate lymph node assessments (ALNA).
Sep 25, 2006, 18:38
Telomerase inhibitors may revolutionize cancer therapy
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development.
Sep 21, 2006, 20:19
Renal cancer related to deficiency in exposure to sunlight
Using newly available data on worldwide cancer incidence to map cancer rates in relation to proximity to the equator, researchers at the Moores Cancer Center at University of California, San Diego (UCSD) have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B (UVB), and kidney cancer.
Sep 19, 2006, 14:53
Pain associated with prostatic biopsy is related to the site biopsied
Researchers at Mayo Clinic have evaluated the major sources of pain for some men during in-office prostate biopsy and an anesthetic method that can best lessen it. Findings will be presented in two abstracts Thursday at the annual meeting of the North Central Section of the American Urological Association in San Diego.
Sep 15, 2006, 03:02
Ovariectomy may put younger women at risk for an earlier death
Death rates rise when women under 45 years old undergo bilateral ovariectomy -- surgical removal of both ovaries -- and do not receive proper hormone replacement therapy, according to a new Mayo Clinic study to be published in the October 1 issue of The Lancet Oncology. Mortality from all causes increased 1.7 times for women in this age category, and was particularly increased for estrogen-related cancers and diseases of the brain and cardiovascular system. The increased risk was mainly restricted to those women who were not given estrogen after the surgery until at least age 45 (within five years of the approximate age of normal menopause). Also, the increased risk became evident only 10 or more years after the ovariectomy.
Sep 14, 2006, 05:40
Regular aerobics protects men from colon cancer
Regular, moderate-to-vigorous aerobic exercise significantly reduces a risk factor associated with the formation of colon polyps and colon cancer in men, according to a study led by researchers at Fred Hutchinson Cancer Research Center.
Sep 13, 2006, 20:04
TCGA Pilot Project to cover lung, brain and ovarian cancers
Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), today announced the first three cancers that will be studied in the pilot phase of The Cancer Genome Atlas (TCGA) project.
Sep 13, 2006, 19:53
Raloxifene Reduces Breast Cancer Risk in Postmenopausal Women at All Risk Levels
Raloxifene protects postmenopausal women from developing invasive breast cancer whether they are at high or low risk of developing the disease, according to a new study. The study, published in the September 1 issue of Clinical Cancer Research, also revealed that the drug appears to reduce risk in women with a family history of breast cancer down to a similar level to women without affected relatives. Compared with a placebo drug, the study found that use of raloxifene was associated with a 58 percent reduction in breast cancer risk in women without a family history of the disease, and an 89 percent reduction in risk for women with a family history of breast cancer.
Sep 13, 2006, 12:03
Vitamin D May Cut Pancreatic Cancer Risk by Nearly Half
Consumption of Vitamin D tablets was found to cut the risk of pancreatic cancer nearly in half, according to a study led by researchers at Northwestern and Harvard universities. The findings point to Vitamin D’s potential to prevent the disease, and is one of the first known studies to use a large-scale epidemiological survey to examine the relationship between the nutrient and cancer of the pancreas. The study, led by Halcyon Skinner, Ph.D., of Northwestern, appears in the September issue of Cancer Epidemiology Biomarkers & Prevention.
Sep 13, 2006, 12:00
Physical activity improves survival in breast cancer patients
Women who reported the highest levels of physical activity in the year before they were diagnosed with breast cancer may have higher survival, according to a new study.
Sep 11, 2006, 16:45
Pedigree assessment tool correctly identifies women with higher risk of breast cancer
A new screening tool for the general practitioner effectively identifies patients at risk for hereditary breast cancer, according to a new study.
Sep 11, 2006, 16:40
Colchicine can delay the development of hepatocellular carcinoma
Colchicine, an anti-inflammatory drug most often used to treat gout, prevented liver cancer in patients with hepatitis virus-related end-stage liver disease, according to a new study.
Sep 11, 2006, 16:22
Drosophila RNAi analysis may help understanding metastasis of the cancers
The humble fruit fly and a grant from the AICR – the Association for International Cancer Research - are helping a leading scientist in London identify potential targets for drugs that block the spread of cancer.
Sep 8, 2006, 17:06
MRI more accurately determines cancer spread into breast ducts
MRI is better than MDCT for determining if and how far breast cancer has spread into the breast ducts and should be used before patients receive breast conserving therapy, a new study shows.
Sep 4, 2006, 17:03
3D-CRT brings hope for inoperable lung cancers
Modern three-dimensional radiation therapy has been proven to be more successful at curing lung cancer than older two-dimensional radiation therapy for some patients with early stage lung cancer, according to a new study in the September 1, 2006 edition of the International Journal of Radiation Oncology * Biology * Physics, the official journal of the American Society for Therapeutic Radiology and Oncology (ASTRO).
Sep 1, 2006, 17:34