||Last Updated: Nov 17th, 2006 - 22:35:04
Breast cancer chemotherapy may deterioration in cognitive function
A new study investigating the effects of chemotherapy on cognitive function in mice has confirmed what many cancer patients receiving treatment have often complained about – a decline in their memory and other cognitive functions, sometimes characterized as "chemobrain". The study, led by Dr. Gordon Winocur of the Baycrest Research Centre for Aging and the Brain, in collaboration with Drs. Ian Tannock and Janette Vardy of Princess Margaret Hospital, was conducted at Trent University. The findings are published in the September 2006 issue of Pharmacology, Biochemistry and Behavior (Vol. 85, Issue 1), which will be available online in the next week. The results were presented at a workshop held in conjunction with the 8th World Congress of Psycho-Oncology in Venice last week.
Oct 29, 2006, 21:32
Elderly Breast Cancer Patients May Be Under-Diagnosed And Under-Treated
Elderly patients with breast cancer who received care in a community hospital setting may have been under-diagnosed, under-staged and under-treated, according to a report in the October issue of Archives of Surgery, one of the JAMA/Archives journals. The number of older breast cancer patients has increased along with overall elderly population, according to background information in the article. About half of breast cancer patients are older than 65 years and 35 percent are older than 70; 77 percent of breast cancer deaths occur in women older than 55. Choosing the appropriate treatment for older patients is a challenge, because many have other serious illnesses in addition to their cancer that may threaten their health and shorten their lives. Questions remain about the best screening protocols for elderly women, as well. Some current guidelines suggest that women stop having mammograms at age 70, while others provide no upper limit.
Oct 17, 2006, 14:34
Tissue Geometry Plays Crucial Role in Breast Cell Invasion
Apropos of National Breast Cancer Awareness month, researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have created a first-of-its-kind model for studying how breast tissue is shaped and structured during development. The model may shed new light on how the misbehavior of only a few cells can facilitate metastatic invasion because it shows that the development of breast tissue, normal or abnormal, is controlled not only by genetics but also by geometry. Though created specifically for the study of breast tissue, this model should also be applicable to the study of tissue development in other organs as well.
Oct 13, 2006, 11:02
Ethnic variations in hormone levels may cause differences in breast cancer risk
Researchers have known that a woman's natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern California (USC) has found that the natural levels of estrogens in post-menopausal women varies by ethnicity and race, and may explain the differences in the groups' breast cancer rates. The study appears in the October issue of Cancer Epidemiology, Biomarkers & Prevention.
Oct 10, 2006, 12:22
Researchers set benchmarks for screening mammography
A recent study of medical audit data funded by the National Cancer Institute (NCI) revealed that community mammography screening results surpass performance recommendations across the United States. Approximately 188 mammography facilities nationwide contributed to the study of more than 1.1 million women, who underwent at least one screening mammography exam between 1996 and 2002. The findings are reported in the October issue of Radiology.
Sep 26, 2006, 23:10
Raloxifene Reduces Breast Cancer Risk in Postmenopausal Women at All Risk Levels
Raloxifene protects postmenopausal women from developing invasive breast cancer whether they are at high or low risk of developing the disease, according to a new study. The study, published in the September 1 issue of Clinical Cancer Research, also revealed that the drug appears to reduce risk in women with a family history of breast cancer down to a similar level to women without affected relatives. Compared with a placebo drug, the study found that use of raloxifene was associated with a 58 percent reduction in breast cancer risk in women without a family history of the disease, and an 89 percent reduction in risk for women with a family history of breast cancer.
Sep 13, 2006, 12:03
Physical activity improves survival in breast cancer patients
Women who reported the highest levels of physical activity in the year before they were diagnosed with breast cancer may have higher survival, according to a new study.
Sep 11, 2006, 16:45
Pedigree assessment tool correctly identifies women with higher risk of breast cancer
A new screening tool for the general practitioner effectively identifies patients at risk for hereditary breast cancer, according to a new study.
Sep 11, 2006, 16:40
MRI more accurately determines cancer spread into breast ducts
MRI is better than MDCT for determining if and how far breast cancer has spread into the breast ducts and should be used before patients receive breast conserving therapy, a new study shows.
Sep 4, 2006, 17:03
Core needle biopsy gives an accurate picture of gene expression
The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour. A study published today in the open access journal Breast Cancer Research confirms the reliability of core needle biopsy as a tool in breast cancer diagnosis and prognosis. The study also shows that the gene expression profile of a core needle biopsy might be more accurate than the profile of a surgical sample taken from the same tumour, after the biopsy was carried out. According to the study results, the biopsy procedure seems to trigger the expression of genes involved in wound healing as well as tumour invasion and metastasis, thus modifying the gene expression profile of subsequent surgical samples.
Aug 19, 2006, 16:40
Ancient war paint in fight against breast cancer
A plant that gave ancient Britons and Celts their blue war paint, has been found to be a rich source of the anti-cancer compound, glucobrassicin, traditionally associated with broccoli. Glucobrassicin has been found to be effective against breast cancer. The war paint, a blue dye, is obtained from Woad, a member of the Brassicaceae family.
Aug 14, 2006, 13:20
Specimen radiography confirms success of MRI-guided breast biopsy
Radiologists can help confirm that an MRI-guided breast biopsy has successfully removed the lesion by taking an x-ray of the lesion and slices of the lesion, a new study shows.
Aug 14, 2006, 12:05
Trastuzumab effective in breast cancer cells with low HER-2 levels
Northwestern University and Evanston Northwestern Healthcare researchers have discovered that the monoclonal antibody Herceptin (trastuzumab) used in combination with certain cancer chemotherapies effectively treats breast cancer tumors that produce low or undetectable amounts of the HER-2 oncogene but overexpress the growth factor heregulin (HRG), an activator of the HER-2 cancer oncoprotein. Increased levels of HER-2 are associated with poor patient prognosis, enhanced metastasis (cancer spread) and resistance to chemotherapy.
Aug 11, 2006, 20:15
Breast cancer survivors change lifestyle after diagnosis
Breast cancer survivors' beliefs about what may have caused their cancer are connected to whether they make healthy lifestyle changes after a cancer diagnosis. This is the finding of a research study appearing in the August 2006 issue of Psycho-Oncology by researchers at The Miriam Hospital and Brown Medical School.
Aug 11, 2006, 19:49
Computer-aided detection improves early breast cancer identification
Computer-aided detection improves breast cancers in both screening and diagnostic patients according to a recent study done by a private practice radiologist in Santa Barbara, CA. The study was conducted to evaluate the impact of CAD in a non-academic setting, most notably its effect on cancer detection in both screening and diagnostic patients. The positive predictive value (PPV) of biopsy recommendations, biopsy rate, and recall rate before and after the introduction of CAD were compared. Then, size, stage, and histology of cancers detected with and without CAD findings were evaluated.
Aug 3, 2006, 17:51
Do close surgical margins predict if breast cancer will return?
A new study published in the August 1, 2006, issue of the International Journal of Radiation Oncology * Biology * Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology, says that cancer cells present after additional surgery for breast cancer may predict whether a woman will see her cancer return.
Aug 2, 2006, 11:51
CHEK2*1100delC mutation may triple breast cancer risk
A study of more than 9,000 Danish residents shows that a specific variation in the CHEK2 gene may triple a woman's risk of developing breast cancer in her lifetime. The study--the first to examine the prevalence of the CHEK2 mutation in the general population and the associated cancer risk--will be published online July 31 in the Journal of Clinical Oncology.
Aug 1, 2006, 13:39
Google-like process for mammogram images speeds up interpretations
To help computers provide faster "second opinions" on mammogram images showing suspicious-looking breast masses, medical physicists at Duke University are employing a Google-like approach that retrieves useful information from an existing mammogram database within three seconds. Rather than comparing the mammogram image in question to every image of breast cancer in a computer database, the new approach compares the mammogram in question to selected images that are most highly ranked for their information content. This is analogous to how a Google search first returns a list of only those websites that it determines to have the most important and useful information on the words entered in the search. In a pilot study that will be presented in August at the 48th Annual Meeting of the American Association of Physicists in Medicine in Orlando, the approach enabled computers to maintain their high level of accuracy while performing faster analysis. Such speed and efficiency will be important as such image databases rapidly grow larger and more complex.
Jul 26, 2006, 15:00
Breast stem cells have features similar to 'basal' tumors
The most aggressive form of breast cancer may originate from breast stem cells that have undergone genetic mishaps. Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using mouse models, have discovered that breast stem cells do not express receptors for the female hormones oestrogen or progesterone. These and other features of the stem cell resemble the aggressive 'basal' subtype of breast cancer. There is increasing evidence that breast cancer is not simply a single disease. Scientists now view breast cancer as a heterogeneous disease, made up of various subtypes. This observation has led to speculation that breast tumours are derived from different cell types that could include the breast stem cell or its descendents that have suffered genetic accidents.
Jul 20, 2006, 20:15
New molecular marker of resistance to chemotherapy in breast cancer
A collaborative study between the Hospital Clínic and the Hospital del Mar de Barcelona permits to establish a predictive factor in the resistance to chemotherapy in breast cancer and to establish possible therapeutic targets for the improvement of this treatment. This study has been published this month in the journal Endocrine-Related Cancer and is the result of the work initiated by Dr. Albanell's Group in Hospital Clínic, and finished in Hospital del Mar, where he leads the Unit of Oncology since almost a year. From the beginning, this study had the participation of the Unit of Pathology and Oncology of Hospital del Mar, and the Unit of Research on Cancer Experimental Therapeutics of Hospital del Mar-IMIM.
Jul 10, 2006, 20:14
ATM Gene Fault Doubles Breast Cancer Risk
The risk of developing breast cancer is doubled in women who inherit a damaged version of a gene called ATM, according to a study published by Cancer Research UK funded scientists and collaborators in Nature Genetics today (Monday).
Jul 10, 2006, 19:19
Boost radiotherapy effective for ductal carcinoma in situ
Radiotherapy of the whole breast followed by a boost could stop the very early stages of breast cancer from returning claim researchers from the international Rare Cancer Network in paper published online today by The Lancet Oncology. This strategy should therefore be considered in addition to surgery for patients with the breast-cancer precursor called ductal carcinoma in situ, or DCIS.
Jul 10, 2006, 19:08
Chest X-ray exposure increase likelihood of breast cancer among BRCA1/2 mutation carriers
"Since BRCA proteins are integral in repairing damage to breast cells, we hypothesized that women with BRCA 1/2 mutations would be less able to repair damage caused to DNA by ionizing radiation. Our findings support this hypothesis and stress the need for prospective studies."
Jun 27, 2006, 20:30
Raloxifene Effectively Reduce Breast Cancer Risk
Raloxifene and tamoxifen are both effective in reducing the risk of invasive breast cancer, but each has potential disease and quality of life side effects that women and their physicians will need to consider, according to two reports and an editorial published in the June 21 issue of JAMA.
Jun 21, 2006, 03:51
Safe side effect profile for HER-2 positive breast cancer patients using trastuzumab
Researchers in the North Central Cancer Treatment Group (NCCTG) have shown that patients who receive trastuzumab at the same time as post-chemotherapy radiation treatments for HER-2 positive breast cancer have no more risk for major side effects or complications than those who do not receive the drug.
Jun 6, 2006, 01:29
MR spectroscopy significantly reduces need for breast biopsy
In a study featured in the June issue of Radiology, researchers found that imaging suspicious breast lesions with magnetic resonance (MR) spectroscopy reduced the need for biopsy by 58 percent. The investigators, from Memorial Sloan-Kettering Cancer Center in New York, discovered that with the addition of MR spectroscopy to their breast MR imaging (MRI) protocol, 23 of 40 suspicious lesions could have been spared biopsy, and none of the resultant cancers would have been missed.
May 31, 2006, 17:06
Secret herb in tests to stop breast cancer patients' hot flushes and night sweats
Researchers at the University of Manchester are testing a secret herb in a bid to stop the severe hot flushes that besiege breast cancer patients on hormone treatment. Professor Alex Molassiotis, of the School of Nursing, Midwifery and Social Work, says the herb - one of the mint family, found in any kitchen - is thought to stop the hot flushes and night sweats which can be so bad that some women have to change their clothes three or four times a night.
Apr 30, 2006, 19:11
Terahertz imaging may reduce breast cancer surgeries
A promising new technique to ensure complete tumor removal at breast cancer excision is introduced in the May issue of Radiology. Researchers used light waves in a newly explored region of the electromagnetic spectrum--the terahertz region--to examine excised breast tissue and determine if the removed tissue margins were clear of cancer, with good results. This technology has the potential to eliminate the need for multiple surgeries and tissue samples to get clear surgical margins.
Apr 25, 2006, 19:37
Three-dimensional breast stem cell cultures reveal unexpected subtleties in malignancies
Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting. In the human breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now scientists from the Icelandic Cancer Society and the Faculty of Medicine, University of Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties about these stem cells that could explain why they spawn malignancies.
Apr 25, 2006, 17:28
Chemotherapy gel - Polymer based therapy for breast cancer
Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery. Researchers at the McGowan Institute for Regenerative Medicine, in collaboration with bioengineers at Carnegie Mellon University, have developed a polymer-based therapy for breast cancer that could serve as an artificial tissue filler after surgery and a clinically effective therapy.
Apr 25, 2006, 17:23