||Last Updated: Nov 17th, 2006 - 22:35:04
Modifying NFATc1 Triggers Bone Production
Scientists in the US have found a way to trigger bone production, raising hopes of treatment for osteoporosis in humans.
Oct 8, 2006, 16:48
'Magic formula' accurately predicts fracture risk in osteoporotic women
Researchers have developed a mathematic formula to predict a woman's risk of osteoporotic fracture. The equation has proved 75 percent accurate and will allow physicians to tailor their treatment strategies to help women prevent fractures of fragile bones. The study appears in the October issue of Radiology.
Sep 26, 2006, 16:40
Calcium supplements fail to prevent bone fractures in children
Calcium supplements have very little benefit for preventing fractures in childhood and later adulthood, concludes a study in the BMJ.
Sep 15, 2006, 18:02
Estrens might not be the answer for osteoporosis
A new study appearing in the September issue of the Journal of Clinical Investigation indicates that caution might be needed if a new group of drugs known as estrens are to be developed for the treatment of osteoporosis. The researchers found that although estrens improved bone strength in mice with osteoporosis, they also had adverse effects on reproductive organs and human breast cancer cells.
Sep 3, 2006, 15:41
Increasing NFATc1 activity causes massive bone accumulation
Howard Hughes Medical Institute (HHMI) researchers at Stanford University have found that they can increase bone mass in mice by tweaking the shape of a regulatory protein.
Jun 6, 2006, 14:53
Second-Hand Smoke, First-Hand Problem
Young or old, man or woman, smoker or non-smoker – no matter what category you fit into, cigarette smoke can weaken your bones and increase your risk for fractures, according to new research presented this week at the IOF World Congress on Osteoporosis in Toronto.
Jun 6, 2006, 14:50
Using gene therapy to accelerate damaged muscle regeneration
University of Pittsburgh School of Medicine researchers have successfully used gene therapy to accelerate muscle regeneration in experimental animals with muscle damage, suggesting this technique may be a novel and effective approach for improving skeletal muscle healing, particularly for serious sports-related injuries.
Jun 5, 2006, 16:44
Low carbohydrate diet did not increase bone loss
A strict low-carbohydrate diet had no effect on bone loss for adults following an Adkins-type diet for weight loss, a three-month study by rheumatologists at the University of South Florida found. The clinical study was published this week in the online issue of the journal Osteoporosis International.
May 25, 2006, 13:16
Teriparatide to be tested for osteogenesis imperfecta
Jimmy Fox isn't typical of a person with the genetic, "brittle bone" disorder osteogenesis imperfecta (OI). He lifts weights almost daily, participates in grueling wheelchair races, chops wood and enjoys hunting in rough backcountry.
May 19, 2006, 19:36
A novel vertebroplasty technique strengthens vertebrae after removing spinal tumors
A radiologist at the University of California, San Diego (UCSD) School of Medicine has developed a new procedure to treat fractured vertebrae caused by spinal tumors, a procedure that may decrease the risk of complications, which are experienced by 5 to 10% of patients with malignant tumors of the spine.
May 6, 2006, 19:00
ACVR1 Gene Responsible for Fibrodysplasia ossificans progressiva (FOP)
Scientists have identified a gene that turns muscle into bone - one of the rarest disorders that affects about one in two million individuals.
Apr 25, 2006, 20:35
Calcium fortified food may not produce stronger bones
Calcium fortified foods may not help build stronger bones in children, says a new study. Calcium is a mineral important to maintaining bone health. Calcium-rich foods include milk, cheese, yoghurt, greens, broccoli, sardines, beans and peas. The mineral is added to many breakfast cereals, snack bars and drinks as manufacturers try to woo the parental market.
Apr 20, 2006, 15:53
Growing body of research links lead to osteoporosis
Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss. The clinical trial is the latest in a growing body of research that is putting yet one more notch in the belt of diseases attributed to lead, and this time, researchers say, its target is older adults at risk for osteoporosis.
Mar 28, 2006, 22:20
GENOMOS: Weak Links found between COL1A1 Polymorphism, BMD, and Fracture Risk
One out of every two women and one in eight men over 50 will have an osteoporosis-related fracture in their lifetime. Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue, and often progresses without overt symptoms or pain until a bone breaks. Fractures occur typically in the hip, spine, and wrist. Currently, there is no accurate measure of overall bone strength. Bone mineral density (BMD) is frequently used as a proxy measure, but it can explain only a modest proportion of fracture risk.
Feb 24, 2006, 08:47
Denosumab may show promise in the treatment of osteoporosis
Amgen (NASDAQ: AMGN), the world's largest biotechnology company, announced today the publication of Phase 2 data demonstrating twice-yearly injections of denosumab (previously referred to as AMG 162), a RANK Ligand inhibitor, significantly increased bone mineral density (BMD) in the total hip, lumbar spine, distal 1/3 radius and total body compared to placebo. The results of this one-year study appeared in the Feb. 23, 2006 issue of the New England Journal of Medicine. Data results also included an open-label FOSAMAX® (alendronate)* arm of the same clinical trial.
Feb 23, 2006, 15:11
Acupressure Relieves Low Back Pain
Acupressure (applying pressure with the thumbs or fingertips to the same points on the body stimulated in acupuncture) seems to be more effective in reducing low back pain than physical therapy, finds a study published online by the BMJ today.
Feb 17, 2006, 19:05
Warfarin increases risk of bone fracture
Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at Washington University School of Medicine in St. Louis. The results suggest physicians should carefully monitor the bone health of patients placed on the medication and that their patients should take steps to decrease the risk of osteoporosis.
Jan 24, 2006, 17:58
An X-ray robot to scan orthopaedic patients
A US scientist has developed a robot which can take X-ray pictures of sufferers of orthopaedic injuries as they move around. Complaints of orthopaedic injuries are among the most common reasons people visit the doctor.
Jan 21, 2006, 15:33
Mental therapy could help chronic back pain suffers
Mental therapy could be as effective as physical exercise in reducing back pain, signalling relief for thousands of chronic back pain sufferers.
Jan 21, 2006, 15:22
New insights into anti-osteoclastogenic action of vitamin D
The risk of bone fracture resulting from falls increases as we age due to bone loss and osteoporosis. Physicians have routinely prescribed vitamin D and vitamin D–related drugs to retard bone loss, but until now, little was known about the specific targets of vitamin D in bone.
Jan 20, 2006, 13:42
Vertebroplasty improves back pain
A Mayo Clinic study has found patients report less back pain at rest and while active following vertebroplasty, a procedure in which medical cement is injected into painful compression fractures in the spinal vertebrae due to osteoporosis. Patients also reported improved function in their daily activities, such as walking, housework and getting dressed.
Dec 30, 2005, 16:02
Prevent bone loss and periodontal disease
Drugs that reverse and prevent bone loss due to osteoporosis also significantly ward off periodontal disease, according to a graduate of the Case Western Reserve University School of Dental Medicine who reports in the current Menopause journal article, "Periodontal Assessments of Postmenopausal Women Receiving Risedronate
Nov 19, 2005, 02:12
Adequate Vitamin D Maintains Calcium Metabolism
Calcium intake levels of more than 800 mg/day may be unnecessary for maintaining calcium metabolism if vitamin D status is adequate, according to a study in the November 9 issue of JAMA. The importance of adequate vitamin D status for optimum bone health has received increased recognition in recent years, with higher recommended intake levels being proposed by some investigators, according to background information in the article. The ideal intake is not known, and different criteria have been proposed for estimating population requirements. Serum 25-hydroxyvitamin D has been the generally accepted indicator of vitamin D status, but no universal consensus has been reached regarding which serum values constitute sufficiency. An inverse relationship between serum 25-hydroxyvitamin D and serum parathyroid hormone (PTH) is well established. Parathyroid hormone is a major hormone maintaining normal serum concentrations of calcium and phosphate and is itself regulated through levels of calcitriol and serum calcium. An insufficiency of vitamin D or calcium is generally associated with an increase in PTH.
Nov 9, 2005, 20:36
Developing stable, bacteria-resistant implants
Infections associated with inserting a medical device can be devastating, painful, and cause prolonged disability, costing tens of thousands of dollars.
Sep 24, 2005, 15:31
Genetic Factors Influence Propensity To Bone Fractures In Elderly
The importance of genetic factors in an elderly individual's propensity to bone fractures depends on the individual's age and the type of fracture, according to a study in the September 12 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Sep 13, 2005, 13:51
Consumption Of Soy May Reduce Risk Of Fracture In Postmenopausal Women
Postmenopausal women who consumed high daily levels of soy protein had reduced risk of bone fracture, according to a study in the September 12 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Sep 13, 2005, 13:51
Identifying Previously Undectable Spinal Injuries
A new national study indicates that patients with a cervical spinal injury may harbor additional spinal damage not visible on regular x-rays. In fact, more than a third of patients who were thought to have low-risk injuries actually have additional damage that may include significant fractures with the potential to produce serious spinal problems if not detected and treated properly.
Sep 9, 2005, 16:12
Serial bone mineral density (BMD) measurements can improve fracture risk accuracy
Scientists from the Garvan Institute of Medical Research in Sydney, Australia, are suggesting a new approach to determining the risk of fracture in individuals with the brittle bone disease, osteoporosis, which could have treatment implications. Their finding, published in the Journal of Bone and Mineral Research, is based on data from a fifteen-year epidemiology study and shows that calculating bone loss, by having at least two bone mineral density (BMD) measurements taken a minimum of 1-2 years apart, can improve the accuracy of fracture risk assessment.
Aug 29, 2005, 21:59
Brain plays an important role in the bone density maintenance
The brain plays an important role in the maintenance of proper bone density, researchers at the Hebrew University of Jerusalem have revealed.
Aug 25, 2005, 03:53
Dietary calcium can counteract low bone density in oral contraceptive users
Women who take oral contraceptives can counteract bone loss by making sure they have enough calcium in their daily diet, especially early in life, according to Purdue University research.
Aug 18, 2005, 16:31