||Last Updated: Nov 17th, 2006 - 22:35:04
Modifying NFATc1 Triggers Bone Production
Scientists in the US have found a way to trigger bone production, raising hopes of treatment for osteoporosis in humans.
Oct 8, 2006, 16:48
'Magic formula' accurately predicts fracture risk in osteoporotic women
Researchers have developed a mathematic formula to predict a woman's risk of osteoporotic fracture. The equation has proved 75 percent accurate and will allow physicians to tailor their treatment strategies to help women prevent fractures of fragile bones. The study appears in the October issue of Radiology.
Sep 26, 2006, 16:40
Calcium supplements fail to prevent bone fractures in children
Calcium supplements have very little benefit for preventing fractures in childhood and later adulthood, concludes a study in the BMJ.
Sep 15, 2006, 18:02
Estrens might not be the answer for osteoporosis
A new study appearing in the September issue of the Journal of Clinical Investigation indicates that caution might be needed if a new group of drugs known as estrens are to be developed for the treatment of osteoporosis. The researchers found that although estrens improved bone strength in mice with osteoporosis, they also had adverse effects on reproductive organs and human breast cancer cells.
Sep 3, 2006, 15:41
Increasing NFATc1 activity causes massive bone accumulation
Howard Hughes Medical Institute (HHMI) researchers at Stanford University have found that they can increase bone mass in mice by tweaking the shape of a regulatory protein.
Jun 6, 2006, 14:53
Second-Hand Smoke, First-Hand Problem
Young or old, man or woman, smoker or non-smoker – no matter what category you fit into, cigarette smoke can weaken your bones and increase your risk for fractures, according to new research presented this week at the IOF World Congress on Osteoporosis in Toronto.
Jun 6, 2006, 14:50
Low carbohydrate diet did not increase bone loss
A strict low-carbohydrate diet had no effect on bone loss for adults following an Adkins-type diet for weight loss, a three-month study by rheumatologists at the University of South Florida found. The clinical study was published this week in the online issue of the journal Osteoporosis International.
May 25, 2006, 13:16
Growing body of research links lead to osteoporosis
Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss. The clinical trial is the latest in a growing body of research that is putting yet one more notch in the belt of diseases attributed to lead, and this time, researchers say, its target is older adults at risk for osteoporosis.
Mar 28, 2006, 22:20
GENOMOS: Weak Links found between COL1A1 Polymorphism, BMD, and Fracture Risk
One out of every two women and one in eight men over 50 will have an osteoporosis-related fracture in their lifetime. Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue, and often progresses without overt symptoms or pain until a bone breaks. Fractures occur typically in the hip, spine, and wrist. Currently, there is no accurate measure of overall bone strength. Bone mineral density (BMD) is frequently used as a proxy measure, but it can explain only a modest proportion of fracture risk.
Feb 24, 2006, 08:47
Denosumab may show promise in the treatment of osteoporosis
Amgen (NASDAQ: AMGN), the world's largest biotechnology company, announced today the publication of Phase 2 data demonstrating twice-yearly injections of denosumab (previously referred to as AMG 162), a RANK Ligand inhibitor, significantly increased bone mineral density (BMD) in the total hip, lumbar spine, distal 1/3 radius and total body compared to placebo. The results of this one-year study appeared in the Feb. 23, 2006 issue of the New England Journal of Medicine. Data results also included an open-label FOSAMAX® (alendronate)* arm of the same clinical trial.
Feb 23, 2006, 15:11
Warfarin increases risk of bone fracture
Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at Washington University School of Medicine in St. Louis. The results suggest physicians should carefully monitor the bone health of patients placed on the medication and that their patients should take steps to decrease the risk of osteoporosis.
Jan 24, 2006, 17:58
New insights into anti-osteoclastogenic action of vitamin D
The risk of bone fracture resulting from falls increases as we age due to bone loss and osteoporosis. Physicians have routinely prescribed vitamin D and vitamin D–related drugs to retard bone loss, but until now, little was known about the specific targets of vitamin D in bone.
Jan 20, 2006, 13:42
Prevent bone loss and periodontal disease
Drugs that reverse and prevent bone loss due to osteoporosis also significantly ward off periodontal disease, according to a graduate of the Case Western Reserve University School of Dental Medicine who reports in the current Menopause journal article, "Periodontal Assessments of Postmenopausal Women Receiving Risedronate
Nov 19, 2005, 02:12
Genetic Factors Influence Propensity To Bone Fractures In Elderly
The importance of genetic factors in an elderly individual's propensity to bone fractures depends on the individual's age and the type of fracture, according to a study in the September 12 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Sep 13, 2005, 13:51
Consumption Of Soy May Reduce Risk Of Fracture In Postmenopausal Women
Postmenopausal women who consumed high daily levels of soy protein had reduced risk of bone fracture, according to a study in the September 12 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Sep 13, 2005, 13:51
Serial bone mineral density (BMD) measurements can improve fracture risk accuracy
Scientists from the Garvan Institute of Medical Research in Sydney, Australia, are suggesting a new approach to determining the risk of fracture in individuals with the brittle bone disease, osteoporosis, which could have treatment implications. Their finding, published in the Journal of Bone and Mineral Research, is based on data from a fifteen-year epidemiology study and shows that calculating bone loss, by having at least two bone mineral density (BMD) measurements taken a minimum of 1-2 years apart, can improve the accuracy of fracture risk assessment.
Aug 29, 2005, 21:59
Brain plays an important role in the bone density maintenance
The brain plays an important role in the maintenance of proper bone density, researchers at the Hebrew University of Jerusalem have revealed.
Aug 25, 2005, 03:53
Dietary calcium can counteract low bone density in oral contraceptive users
Women who take oral contraceptives can counteract bone loss by making sure they have enough calcium in their daily diet, especially early in life, according to Purdue University research.
Aug 18, 2005, 16:31
Vitamin D supplements not helpful in black women
The researchers found that there was no significant difference in BMD in women receiving vitamin D and women receiving placebo. There was also no relationship found between 25-OHD blood levels and bone density change in either group.
Jul 29, 2005, 15:37
Vitamin D, Calcium Ineffective in Preventing Fractures
A study in this week's BMJ finds no evidence that calcium and vitamin D supplements reduce the risk of fractures in older women living in the community.
Apr 29, 2005, 14:29
Calcium Supplements Unable to Prevent Fractures
The findings are reported today in The Lancet and follow a major 5½ year trial involving almost 5,300 people aged 70 and over who had suffered a fracture in the last 10 years. Participants were recruited through fracture clinics and in-patient wards at 21 hospitals across the UK.
Apr 28, 2005, 18:17
IRAK-M - Key regulator of bone cells linked to osteoporosis
Scientists at the Yale School of Medicine identified a molecule in osteoclasts, IRAK-M, that is a key regulator of the loss of bone mass.
Apr 6, 2005, 19:00