||Last Updated: Nov 17th, 2006 - 22:35:04
Faults in housekeeping genes regulating protein trafficking results in skeletal deformities
A defective link in the intracellular protein "transit system" may lie at the heart of some craniofacial defects, new research in zebrafish suggests.
Sep 19, 2006, 15:01
Neural stem cells derived from human embryonic stem cells carry abnormal gene expression
Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.
Researchers from the Institute for Stem Cell Biology and Medicine at UCLA coaxed cells from the federally approved line to differentiate into neural stem cells, a process that might one day be used to grow replacement cells to treat such debilitating diseases as Parkinson's and Alzheimer's. However, the neural stem cells expressed a lower level of a metabolic gene called CPT 1A, a condition that causes hypoglycemia in humans.
Aug 6, 2006, 06:47
Neurons grown from embryonic stem cells restore function in paralyzed rats
For the first time, researchers have enticed transplants of embryonic stem cell-derived motor neurons in the spinal cord to connect with muscles and partially restore function in paralyzed animals. The study suggests that similar techniques may be useful for treating such disorders as spinal cord injury, transverse myelitis, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy. The study was funded in part by the NIH's National Institute of Neurological Disorders and Stroke (NINDS). The researchers, led by Douglas Kerr, M.D., Ph.D., of The Johns Hopkins University School of Medicine, used a combination of transplanted motor neurons, chemicals capable of overcoming signals that inhibit axon growth, and a nerve growth factor to attract axons to muscles. The report is published in the July 2006 issue of Annals of Neurology.
Jun 21, 2006, 00:45
New stem-cell findings can help the body to cure itself
Researchers at Karolinska Institutet have identified an important mechanism that regulates how many new cells are produced by each intestinal stem cell. The study is published in the latest issue of the prestigious scientific journal, Cell. "This might eventually help us develop new drugs for things like neurological disorders and anaemia," says Professor Jonas Frisén.
Jun 16, 2006, 00:49
Putting avian transgenics on a par with transgenic mice
Origen Therapeutics announced today that it has succeeded in developing a robust and versatile technology for genetically modifying chickens that, for the first time, puts avian transgenics on a par with transgenic mice. The company made the announcement in conjunction with the publication of an article this week by Origen scientists and a collaborator from the University of California, Davis on its transgenic technology in the journal Nature. Using the new technology, Origen can, in principle, make any genetic modification desired to the chicken genome, including the insertion of genetic elements for the production of human therapeutics and the modification of the chicken immune system to produce novel human sequence polyclonal antibodies. Moreover, the new technology opens up the possibility of producing chickens with enhanced agronomic traits, including resistance to avian flu.
Jun 8, 2006, 07:43
Harvard to Create Human Embryonic Stem Cell Lines
After more than two years of intensive ethical and scientific review, Harvard Stem Cell Institute (HSCI) researchers at Harvard and Children's Hospital Boston have been cleared to begin experiments using Somatic Cell Nuclear Transfer (SCNT) to create disease-specific stem cell lines in an effort to develop treatments for a wide range of now-incurable conditions afflicting tens of millions of people.
Jun 7, 2006, 19:57
Stem Cell Study for Patients with Heart Attack Damage Seeks to Regenerate Heart Muscle
Rush cardiologists are hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue.
Apr 22, 2006, 19:16
Stem cells - An alternative to skin grafting?
A Singapore company has used stem cells to help victims of serious burns and other wounds grow fresh skin, its chief medical officer said in a report published Friday.
Apr 7, 2006, 13:46
Bone morphogenetic protein 6 (BMP-6) factor stimulates cartilage growth from stem cells
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Apr 5, 2006, 14:42
Doctors grow organ from patients' own cells
For the first time in medical history, scientists have grown a human organ from patients' own cells to transplant back into their bodies.
Apr 5, 2006, 14:16
Stem cells can repair torn tendons or ligaments
Weekend athletes who overexert themselves running or playing basketball may one day reap the benefits of research at the Hebrew University of Jerusalem that shows that adult stem cells can be used to make new tendon or ligament tissue.
Apr 5, 2006, 13:35
New research could coax bone cells into produce up to 75 times more calcium
In a significant advance for regenerative medicine, researchers at Rice University have discovered a new way to culture adult stem cells from bone marrow such that the cells themselves produce a growth matrix that is rich in important biochemical growth factors.
Feb 14, 2006, 17:13
Stem cell injections may prove beneficial in treating peripheral artery disease
Indiana University School of Medicine scientists have begun a unique clinical trial using stem cell injections as a treatment that could offer hope to tens of thousands of people who face sores, ulcers and even amputations due to severe peripheral artery disease.
Feb 10, 2006, 16:00
New mechanism potentially explain evolution of signalling pathways
Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways.
Feb 8, 2006, 11:19
Hyperbaric oxygen treatments mobilize stem cells
According to a study to be published in the American Journal of Physiology-Heart and Circulation Physiology, a typical course of hyperbaric oxygen treatments increases by eight-fold the number of stem cells circulating in a patient's body. Stem cells, also called progenitor cells are crucial to injury repair. The study currently appears on-line and is scheduled for publication in the April 2006 edition of the American Journal. Stem cells exist in the bone marrow of human beings and animals and are capable of changing their nature to become part of many different organs and tissues. In response to injury, these cells move from the bone marrow to the injured sites, where they differentiate into cells that assist in the healing process. The movement, or mobilization, of stem cells can be triggered by a variety of stimuli – including pharmaceutical agents and hyperbaric oxygen treatments. Where as drugs are associated with a host of side effects, hyperbaric oxygen treatments carry a significantly lower risk of such effects.
Jan 1, 2006, 21:02
Clinical trial to test stem cell approach for children with brain injury
A unique clinical trial will gauge the safety and potential of treating children suffering traumatic brain injury with stem cells derived from their own bone marrow starting early next year at The University of Texas Medical School at Houston and Memorial Hermann Children's Hospital.
Dec 23, 2005, 03:07
How stem cells become brain cells
Continued research could result in new therapies for those who suffer brain injury, Parkinson's disease and other conditions related to lost or damaged brain cells
Dec 15, 2005, 16:12
Human Brain Cells Grown Inside Mouse Skull
Previous studies have shown that undifferentiated human embryonic stem cells (hESC) can survive in the brains of laboratory rats with Parkinson’s disease. But until now it was unclear whether hESCs can become fully functional members of the host animal’s neuronal architecture - a basic necessity if stem cells are ever to be used in medical treatments replenishing missing or damaged neurons in human patients with neurodegenerative diseases such as Parkinson's or Alzheimer’s disease. Now, research at the Salk Institute for Biological Studies indicates for the first time that hESCs mature into fully functional adult brain cells and integrate into the existing nervous system when these human cells are injected in the developing brains of two-week-old mouse embryos. The Salk researchers led by Fred H. Gage, Ph.D, professor and co-head of the Laboratory of Genetics at the Salk Institute, published their finding in this week’s Proceedings of the National Academy of Science.
Dec 13, 2005, 15:29
Stem cells may trigger bone cancer
Stem cells may cause some forms of bone cancer, University of Florida scientists report. The researchers are the first to identify a population of cells with characteristics of adult and embryonic stem cells in cultures derived from biopsies of patients' bone tumors. They describe their findings in this month's issue of the medical journal Neoplasia. "We're saying the cell of origin of these tumors may be very, very primitive," said C. Parker Gibbs, M.D., an associate professor of orthopaedic oncology and a member of the UF Shands Cancer Center. Gibbs collaborated with several UF scientists, including Dennis A. Steindler, Ph.D., director of UF's McKnight Brain Institute. Researchers elsewhere already have implicated stem cells in the development of leukemia, and Steindler's lab previously discovered stem-like cells in brain cancer. Others have identified these same cells in some breast cancers.
Nov 23, 2005, 21:30
Stem cells successfully grown into cartilage cells
Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation. Cartilage is the dense connective tissue usually found between bones to allow the smooth movement of joints. Research to be published in Tissue Engineering shows how the Imperial team directed embryonic stem cells to become cartilage cells. This could allow doctors to grow cartilage for transplantation for a number of injuries and medical problems, including sports injuries, new cartilage for people having hip replacements, and even for cosmetic surgery.
Nov 16, 2005, 20:57
Functional ion channels in human embryonic stem cells (ESCs) discovered
Researchers from Johns Hopkins have discovered the presence of functional ion channels in human embryonic stem cells (ESCs). These ion channels act like electrical wires and permit ESCs, versatile cells that possess the unique ability to become all cell types of the body, to conduct and pass along electric currents.
Oct 22, 2005, 02:33
New Approach Maintains Developmental Potential of Embryo
The generation of embryonic stem cell lines using an alternative approach that does not interfere with the developmental potential of embryos is possible. The research, which appears online (ahead of print) in the journal Nature, by ACT and its collaborators, describes a method of deriving stem cells in mice using a technique of single-cell embryo biopsy similar to that used in preimplantation genetic diagnosis (PGD) to test for genetic defects.
Oct 18, 2005, 13:56
Spinal cord injury treatment with neural stem cells
Researchers at the UC Irvine Reeve-Irvine Research Center have used adult human neural stem cells to successfully regenerate damaged spinal cord tissue and improve mobility in mice.
Sep 20, 2005, 20:38
SPECT/CT can trace stem cells’ destinations after being injected
A team of scientists from the Johns Hopkins Department of Radiology and Institute of Cell Engineering has used a non-invasive imaging technique, called SPECT/CT, to successfully trace stem cells’ destinations after being injected into the body to treat animal hearts damaged by myocardial infarction, or heart attack.
Sep 14, 2005, 21:38
A new link between stem cells and tumors
Scientists at the European Molecular Biology Laboratory [EMBL] in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona [IRB-PCB] have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in the on-line edition of Nature Genetics [September 4] shows that if key molecules aren't placed in the right locations within stem cells before they divide, the result can be deadly tumors.
Sep 14, 2005, 03:38
Full cascade of events during fertilization tracked for first time
Researchers have capitalized on the unique properties of a sperm cell to follow cell membrane fusion as it occurs during fertilization, tracking the full cascade of events for the first time. The findings could reveal new ways to enhance or block fertilization, as well as how to control the secretion of neurotransmitters and hormones such as insulin.
Sep 6, 2005, 06:41
Some cancers originate with defects in stem cells
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in the on-line edition of Nature Genetics (September 4) shows that if key molecules aren't placed in the right locations within stem cells before they divide, the result can be deadly tumors.
Sep 6, 2005, 06:34
Challenging the accepted theory of stem cell operation in kidney repair
Paracrine cell signaling, not differentiation, appears to be how stem cells work in initial phase of organ protection, repair
Sep 4, 2005, 09:10
Adipose tissue stem cells could be used to treat injured or damaged tissues
National and international scientists, including those from the University of Virginia Health System, will announce findings from a significant number of studies showing that adult stem cells from adipose tissue (fat) could eventually be used to treat injured or damaged tissues. They will present their research findings at the Omni Hotel in Charlottesville, Virginia, September 10-13, during the third annual International Fat Applied Technology Society conference, The Role of Adipose Tissue in Regenerative Medicine: Opportunities for Clinical Therapy. Reporters are invited to attend and a press room will be open to meet their needs.
Sep 4, 2005, 08:24
Fusing adult somatic cells with embryonic stem cells - New Technique
Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.
Aug 22, 2005, 21:41