||Last Updated: Nov 17th, 2006 - 22:35:04
Occupational therapy improves quality of life for dementia patients
Occupational therapy can help to improve the ability of people with dementia to perform daily activities and can also reduce the pressure on their caregivers, says a BMJ study published today.
Nov 17, 2006, 13:34
Resveratrol Increases Lifespan of Obese Mice
Researchers have used a single compound to increase the lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets--some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Medical School and the National Institute on Aging, is the first time that the small molecule resveratrol has been shown to offer survival benefits in a mammal. The study is reported in the November 1 advanced online edition of Nature.
Nov 3, 2006, 04:12
Hope remains for Alzheimer's sufferers
The National Institute of Clinical Excellence (NICE), who last week rejected appeals to allow patients with mild Alzheimer's to receive the life-changing medication donepezil (Aricept®), will hopefully re-appraise their decision in three-years time, according to neurologist Professor Robert Kerwin in an article published in the November issue of the medical journal Future Neurology.
Oct 31, 2006, 16:08
Cognitive Decline is Often Undetected - Study
Many patients over the age of 65 who are hospitalized with an acute illness experience a subtle change in their cognitive ability that often goes undiagnosed, untreated and underreported. As a result, a patient's ability to make decisions about his or her medical treatment may be negatively impacted.
Oct 28, 2006, 05:30
CATIE Study: Antipsychotics in Alzheimer's No Better Than Placebo
Most Alzheimer’s patients prescribed antipsychotic drugs for delusions, agitation or aggression do no better than those who take a placebo because so many discontinue the drugs due to significant side effects, according to a new nationwide study led by Lon Schneider, professor of psychiatry, neurology and gerontology at the Keck School of Medicine of USC.
Oct 13, 2006, 11:08
Age-related hearing and vision loss found to be associated
Older adults with vision loss may be more likely to also have hearing loss, and the opposite appears true as well, according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals. In 1994, 18 percent of U.S. adults older than 70 reported impaired vision, 33 percent reported hearing problems and 9 percent reported both, according to background information in the article. Because more adults are living longer and the number of older adults is increasing, the burden associated with such age-related sensory impairments may be increasing.
Oct 11, 2006, 04:53
Mediterranean diet associated with a lower risk for Alzheimer’s disease
Eating a Mediterranean diet, which emphasizes fruits, vegetables and olive oil and includes little red meat, is associated with a lower risk for Alzheimer’s disease, according to an article posted online today that will appear in the December 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals. This association persisted even when researchers considered whether individuals had vascular diseases—diseases of the blood vessels, such as stroke, heart disease and diabetes—suggesting that the diet may work through different pathways to reduce Alzheimer’s disease risk.
Oct 11, 2006, 04:51
Omega-3 fatty acid supplements may slow cognitive decline
Omega-3 fatty acid supplements may slow cognitive decline in some patients with very mild Alzheimer’s disease, but do not appear to affect those with more advanced cases, according to results of a clinical trial published in the October issue of Archives of Neurology, one of the JAMA/Archives journals.
Oct 11, 2006, 04:48
Thyroid hormone play an important role in longevity
The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism, a new study has found.
Oct 10, 2006, 12:38
Laser probe of a brain pigment's anatomy may offer insight into Parkinson's disease
In a finding that may offer clues about Parkinson's disease, a team led by Duke University researchers used a sophisticated laser system to gain evidence that a dark brown pigment that accumulates in people's brains consists of layers of two other pigments commonly found in hair.
Sep 26, 2006, 23:15
Microscopic brain damage detected in early Alzheimer's disease
Researchers have developed a new computer-aided analysis technique to identify early cellular damage in Alzheimer's disease (AD). The study is featured in the October issue of Radiology. "With increasing longevity among the population, the incidence of AD is expected to rise rapidly, creating a great burden not only for patients and their families, but also for society," said Min-Ying Su, Ph.D., author and associate professor in the Department of Radiological Sciences & the Tu and Yuen Center for Functional Onco-Imaging at the University of California at Irvine. "Our methods may enable earlier diagnosis of AD, allowing earlier intervention to slow down disease progression," she added.
Sep 26, 2006, 23:08
Novel technique can identify early cellular damage in Alzheimer's disease
Researchers have developed a new computer-aided analysis technique to identify early cellular damage in Alzheimer's disease (AD). The study is featured in the October issue of Radiology.
Sep 26, 2006, 16:33
Cathepsin B - Part of protective mechanism against Alzheimer's
An enzyme found naturally in the brain snips apart the protein that forms the sludge called amyloid plaque that is one of the hallmarks of Alzheimer's disease (AD), researchers have found. They said their findings in mice suggest that the protein, called Cathepsin B (CatB), is a key part of a protective mechanism that may fail in some forms of AD.
Sep 21, 2006, 00:02
Novel blood test for early detection of Parkinson's, receives national recognition
The research of Dr Kay Double, an NHMRC Senior Research Fellow at the Prince of Wales Medical Research Institute, has received the nation's highest commendation through her inclusion in the NHMRC's 2006 "10 of the Best" booklet.
Sep 1, 2006, 17:29
Boosting ubiquitin C-terminal hydrolase L1 (Uch-L1) restores lost memory
Researchers at Columbia University Medical Center have successfully restored normal memory and synaptic function in mice suffering from Alzheimer's disease. The study was published today on the website of the journal Cell.
Aug 25, 2006, 19:29
Waist-hip ratio should replace body mass index as indicator of mortality risk in older people
Older people with high waist-hip ratios (WHRs) have a higher mortality risk than those with a high body mass index, or BMI, a new study reveals. Whereas justifiable attention is given to the increasing problem of obesity in the general population, far less is known about the relationship between obesity and mortality in older people, or how mortality risk should be estimated. The excess health risks associated with having a high BMI are known to decline with age, yet expert bodies such as the National Institutes of Health and the World Health Organisation have continued to use in older people the same BMI criteria as for other age groups.
Aug 19, 2006, 17:36
Copper-Rich Diets Linked With Cognitive Decline In Older Adults
Among older adults whose diets are high in saturated and trans fats, a high intake of copper may be associated with an accelerated rate of decline in thinking, learning and memory abilities, according to a report in the August issue of the Archives of Neurology, one of the JAMA/Archives journals.
Aug 15, 2006, 13:24
Investigating the connection between cell aging and the onset of proteotoxicity
Alzheimer's disease now strikes more than one in 30 Americans, and about half the population that lives past 85 acquires Alzheimer's. Approximately one million Americans have Parkinson's disease, including three out of every 100 people over age 60. Aging is the most important risk factor for both of these diseases.
Aug 14, 2006, 11:37
Exercise helps sustain mental activity as we age
Based on a review of studies on exercise and its effect on brain functioning in human and animal populations, researchers find that physical exercise may slow aging's effects and help people maintain cognitive abilities well into older age. Animals seem to benefit from exercise too and perform spatial tasks better when they are active. Furthermore, fitness training – an increased level of exercise – may improve some mental processes even more than moderate activity, say the authors of the review.
Aug 11, 2006, 20:05
New research points toward mechanism of age-onset toxicity of Alzheimer's protein
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life, raising the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form. Now, a collaboration between researchers at the Salk Institute for Biological Studies and the Scripps Research Institute shows that aging is what's critical. Harmful beta amyloid aggregates accumulate when aging impedes two molecular clean-up crews from getting rid of these toxic species.
Aug 11, 2006, 13:40
New genetic model for Parkinson's disease
Researchers at the Karolinska Institute in Sweden are homing in on mechanisms that may explain one set of causes for Parkinson's disease. In mice they have mimicked disturbances of mitochondria thought to be one cause of disease. By genetic means the disturbance of mitochondria - the energy factories of cells - were directed to those nerve cells that produce the transmitter substance dopamine and that die in Parkinson's disease.
Jul 31, 2006, 11:29
HIV mutation is clue to why only some people develop AIDS dementia
The study of 18 HIV-positive subjects shows that HIV in the brain and central nervous system is genetically different from HIV that lives in the blood and peripheral tissues. Moreover, serious cognitive impairment among the study subjects was correlated with the presence of a particular mutation in the HIV envelope gene. The study appears in the July 2006 issue of Brain. It was led by Satish K. Pillai, PhD, a staff research associate at SFVAMC and a postdoctoral fellow at the University of California, San Francisco.
Jul 26, 2006, 13:12
Structure of calbindin-D28K Protein Involved in Preventing Alzheimer’s, Huntington’s Diseases Characterised
Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer’s and Huntington’s.
Jul 26, 2006, 12:22
High estrogen levels associated with dementia in older men
A prospective population-based study has found that higher estrogen levels in older men are associated with an increased risk of dementia. By contrast, levels of testosterone were not associated with cognitive decline. As our population ages, the impact of dementia will grow. By the year 2050, some 13 million Americans could have Alzheimer's disease, which is the most common cause of dementia. Researchers are searching to understand risk factors and some studies have suggested that sex hormones play a role. One large study showed that women receiving estrogen therapy had an increased risk of cognitive impairment and dementia. However, the evidence for how testosterone levels affect men is contradictory.
Jul 24, 2006, 19:30
Enhanced mental and physical activity slows neurological decline
Researchers have uncovered the pathways behind the protection offered by environmental stimulation in Alzheimer's disease, further confirming that enhanced mental and physical activity slows neurological decline. The paper by Ambrée et al., "Reduction of amyloid angiopathy and A-Beta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways," appears in the August issue of The American Journal of Pathology.
Jul 24, 2006, 18:54
Expertise In Brain Stimulation Therapy May Improve Outcomes in Parkinson's Disease
Patients with Parkinson's disease who are undergoing a treatment known as deep brain stimulation may benefit from the direct involvement of a neurologist with expertise both in movement disorders and in deep brain stimulation, according to an article posted online today that will appear in the September 2006 print issue of the Archives of Neurology, one of the JAMA/Archives journals.
Jul 12, 2006, 05:41
Measuring Proteins In Spinal Fluid May Provide Early Clue To Alzheimer's Disease
Early signs of the development of Alzheimer's disease can be seen in the cerebrospinal fluid of middle-aged adults who are genetically predisposed to the neurologic condition, according to a report in the July issue of the Archives of Neurology, one of the JAMA/Archives journals.
Jul 12, 2006, 05:37
Teddies May Improve Quality of Life in Alzheimers
Dolls and teddy bears can help Alzheimer's patients interact and communicate with others, finds a new study. A team of doctors at Newcastle General Hospital studied the benefits of dolls after seeing how a patient bonded with a teddy bear from her son, reported the online edition of BBC News.
Jul 10, 2006, 20:49
Pesticide Dieldrin Linked to Increased Risk of Parkinson's Disease
A team of Emory University researchers has found a connection in laboratory mice between developmental exposure to the pesticide dieldrin (now banned from use) during gestation and lactation and an increased risk of developing Parkinson’s disease (PD). The findings are significant because most studies aimed at determining the disease process in PD have been focused on events occurring during adulthood, not during developmental stages.
Jul 7, 2006, 13:10
Alzheimer's pathology related to episodic memory
Alzheimer's pathology can appear in the brains of older men and women without dementia or mild cognitive impairment. The pathology is related to loss of episodic memory, according to a new study published in the June 27, 2006, issue of Neurology, the scientific journal of the American Academy of Neurology.
Jun 30, 2006, 02:34