||Last Updated: Nov 17th, 2006 - 22:35:04
Occupational therapy improves quality of life for dementia patients
Occupational therapy can help to improve the ability of people with dementia to perform daily activities and can also reduce the pressure on their caregivers, says a BMJ study published today.
Nov 17, 2006, 13:34
Hope remains for Alzheimer's sufferers
The National Institute of Clinical Excellence (NICE), who last week rejected appeals to allow patients with mild Alzheimer's to receive the life-changing medication donepezil (Aricept®), will hopefully re-appraise their decision in three-years time, according to neurologist Professor Robert Kerwin in an article published in the November issue of the medical journal Future Neurology.
Oct 31, 2006, 16:08
Cognitive Decline is Often Undetected - Study
Many patients over the age of 65 who are hospitalized with an acute illness experience a subtle change in their cognitive ability that often goes undiagnosed, untreated and underreported. As a result, a patient's ability to make decisions about his or her medical treatment may be negatively impacted.
Oct 28, 2006, 05:30
CATIE Study: Antipsychotics in Alzheimer's No Better Than Placebo
Most Alzheimer’s patients prescribed antipsychotic drugs for delusions, agitation or aggression do no better than those who take a placebo because so many discontinue the drugs due to significant side effects, according to a new nationwide study led by Lon Schneider, professor of psychiatry, neurology and gerontology at the Keck School of Medicine of USC.
Oct 13, 2006, 11:08
Mediterranean diet associated with a lower risk for Alzheimer’s disease
Eating a Mediterranean diet, which emphasizes fruits, vegetables and olive oil and includes little red meat, is associated with a lower risk for Alzheimer’s disease, according to an article posted online today that will appear in the December 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals. This association persisted even when researchers considered whether individuals had vascular diseases—diseases of the blood vessels, such as stroke, heart disease and diabetes—suggesting that the diet may work through different pathways to reduce Alzheimer’s disease risk.
Oct 11, 2006, 04:51
Omega-3 fatty acid supplements may slow cognitive decline
Omega-3 fatty acid supplements may slow cognitive decline in some patients with very mild Alzheimer’s disease, but do not appear to affect those with more advanced cases, according to results of a clinical trial published in the October issue of Archives of Neurology, one of the JAMA/Archives journals.
Oct 11, 2006, 04:48
Microscopic brain damage detected in early Alzheimer's disease
Researchers have developed a new computer-aided analysis technique to identify early cellular damage in Alzheimer's disease (AD). The study is featured in the October issue of Radiology. "With increasing longevity among the population, the incidence of AD is expected to rise rapidly, creating a great burden not only for patients and their families, but also for society," said Min-Ying Su, Ph.D., author and associate professor in the Department of Radiological Sciences & the Tu and Yuen Center for Functional Onco-Imaging at the University of California at Irvine. "Our methods may enable earlier diagnosis of AD, allowing earlier intervention to slow down disease progression," she added.
Sep 26, 2006, 23:08
Novel technique can identify early cellular damage in Alzheimer's disease
Researchers have developed a new computer-aided analysis technique to identify early cellular damage in Alzheimer's disease (AD). The study is featured in the October issue of Radiology.
Sep 26, 2006, 16:33
Cathepsin B - Part of protective mechanism against Alzheimer's
An enzyme found naturally in the brain snips apart the protein that forms the sludge called amyloid plaque that is one of the hallmarks of Alzheimer's disease (AD), researchers have found. They said their findings in mice suggest that the protein, called Cathepsin B (CatB), is a key part of a protective mechanism that may fail in some forms of AD.
Sep 21, 2006, 00:02
Boosting ubiquitin C-terminal hydrolase L1 (Uch-L1) restores lost memory
Researchers at Columbia University Medical Center have successfully restored normal memory and synaptic function in mice suffering from Alzheimer's disease. The study was published today on the website of the journal Cell.
Aug 25, 2006, 19:29
Exercise helps sustain mental activity as we age
Based on a review of studies on exercise and its effect on brain functioning in human and animal populations, researchers find that physical exercise may slow aging's effects and help people maintain cognitive abilities well into older age. Animals seem to benefit from exercise too and perform spatial tasks better when they are active. Furthermore, fitness training – an increased level of exercise – may improve some mental processes even more than moderate activity, say the authors of the review.
Aug 11, 2006, 20:05
New research points toward mechanism of age-onset toxicity of Alzheimer's protein
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life, raising the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form. Now, a collaboration between researchers at the Salk Institute for Biological Studies and the Scripps Research Institute shows that aging is what's critical. Harmful beta amyloid aggregates accumulate when aging impedes two molecular clean-up crews from getting rid of these toxic species.
Aug 11, 2006, 13:40
HIV mutation is clue to why only some people develop AIDS dementia
The study of 18 HIV-positive subjects shows that HIV in the brain and central nervous system is genetically different from HIV that lives in the blood and peripheral tissues. Moreover, serious cognitive impairment among the study subjects was correlated with the presence of a particular mutation in the HIV envelope gene. The study appears in the July 2006 issue of Brain. It was led by Satish K. Pillai, PhD, a staff research associate at SFVAMC and a postdoctoral fellow at the University of California, San Francisco.
Jul 26, 2006, 13:12
Structure of calbindin-D28K Protein Involved in Preventing Alzheimer’s, Huntington’s Diseases Characterised
Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer’s and Huntington’s.
Jul 26, 2006, 12:22
High estrogen levels associated with dementia in older men
A prospective population-based study has found that higher estrogen levels in older men are associated with an increased risk of dementia. By contrast, levels of testosterone were not associated with cognitive decline. As our population ages, the impact of dementia will grow. By the year 2050, some 13 million Americans could have Alzheimer's disease, which is the most common cause of dementia. Researchers are searching to understand risk factors and some studies have suggested that sex hormones play a role. One large study showed that women receiving estrogen therapy had an increased risk of cognitive impairment and dementia. However, the evidence for how testosterone levels affect men is contradictory.
Jul 24, 2006, 19:30
Enhanced mental and physical activity slows neurological decline
Researchers have uncovered the pathways behind the protection offered by environmental stimulation in Alzheimer's disease, further confirming that enhanced mental and physical activity slows neurological decline. The paper by Ambrée et al., "Reduction of amyloid angiopathy and A-Beta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways," appears in the August issue of The American Journal of Pathology.
Jul 24, 2006, 18:54
Measuring Proteins In Spinal Fluid May Provide Early Clue To Alzheimer's Disease
Early signs of the development of Alzheimer's disease can be seen in the cerebrospinal fluid of middle-aged adults who are genetically predisposed to the neurologic condition, according to a report in the July issue of the Archives of Neurology, one of the JAMA/Archives journals.
Jul 12, 2006, 05:37
Teddies May Improve Quality of Life in Alzheimers
Dolls and teddy bears can help Alzheimer's patients interact and communicate with others, finds a new study. A team of doctors at Newcastle General Hospital studied the benefits of dolls after seeing how a patient bonded with a teddy bear from her son, reported the online edition of BBC News.
Jul 10, 2006, 20:49
Alzheimer's pathology related to episodic memory
Alzheimer's pathology can appear in the brains of older men and women without dementia or mild cognitive impairment. The pathology is related to loss of episodic memory, according to a new study published in the June 27, 2006, issue of Neurology, the scientific journal of the American Academy of Neurology.
Jun 30, 2006, 02:34
Mental faculties in Dementia not improved by homocysteine-lowering supplements
Giving healthy older people supplements to reduce high blood levels of an amino acid linked to dementia does not help their cognitive performance, according to a major University of Otago clinical study published today in one of world's top medical journals.
Jun 29, 2006, 04:50
Alzheimer's Memory loss affects more of the brain
Memory loss associated with early Alzheimer's disease (AD) may be linked to altered activity in several areas of the brain, according to a study in the July issue of Radiology. For the first time, researchers at Duke University Medical Center in Durham, N.C., used a special, high-field- strength, functional magnetic resonance imaging (fMRI) scanner to study the brain activity of people with amnestic mild cognitive impairment (MCI), a precursor to AD, and found altered functionality in both the frontal and temporal lobes of the brain. Previous studies looking at structural changes alone have shown evidence that brain atrophy in the earliest stages of AD tends to be restricted to the temporal lobe, a region critical to long-term memory formation.
Jun 27, 2006, 19:09
Factors associated with physical aggression among nursing home residents with dementia
Depressive symptoms, delusions, hallucinations and constipation are associated with physical aggression among nursing home residents with dementia, according to a report in the June 26 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.
Jun 27, 2006, 04:06
Production of amyloid beta peptide (Abeta) monitored for first time in humans
Science is now poised to answer an important and longstanding question about the origins of Alzheimer's disease: Do Alzheimer's patients have high levels of a brain protein because they make too much of it or because they can't clear it from their brains quickly enough?
Jun 27, 2006, 02:45
How restricting caloric intake may prevent Alzheimer
A recent study directed by Mount Sinai School of Medicine suggests that experimental dietary regimens might calm or even reverse symptoms of Alzheimer's Disease (AD). The study, which appears in the July 2006 issue of the Journal of Biological Chemistry, is the first to show that restricting caloric intake, specifically carbohydrates, may prevent AD by triggering activity in the brain associated with longevity.
Jun 15, 2006, 17:54
Mild Cognitive Impairment (MCI) Increases Risk for Alzheimer
Research at the University of Navarra has concluded that some patients with mild cognitive impairment (MCI) will develop Alzheimer in the future. The investigation of the detection of early signals of alteration was based on a multidisciplinary analysis of data from a sample of 300 individuals and undertaken at the University Hospital.
Jun 15, 2006, 17:15
Different forms of amyloid beta in Alzheimer's disease harm neurons in different ways
Researchers at UC Irvine have shown that different forms of amyloid beta lead to neural damage in different ways, leading to an increasingly complex view of amyloid toxicity in the Alzheimer brain. The finding could modify the way therapeutic approaches for the treatment of Alzheimer’s disease are designed.
Jun 1, 2006, 13:06
Social Mealtimes Boost Wellbeing of Nursing Home Residents
Providing a convivial and social environment at mealtimes improves the quality of life and physical performance of nursing home residents, finds a study published on bmj.com. Residents of nursing homes not only face physical deterioration but also loss of independence, privacy, and a familiar environment. These factors lead to high levels of loneliness and depression and a low perceived quality of life.
May 10, 2006, 02:55
Cocktail of dietary supplements holds promise for the treatment of Alzheimer's disease
MIT brain researchers have developed a "cocktail" of dietary supplements, now in human clinical trials, that holds promise for the treatment of Alzheimer's disease. For years, doctors have encouraged people to consume foods such as fish that are rich in omega-3 fatty acids because they appear to improve memory and other brain functions. The MIT research suggests that a cocktail treatment of omega-3 fatty acids and two other compounds normally present in the blood, could delay the cognitive decline seen in Alzheimer's disease, which afflicts an estimated 4 million to 5 million Americans.
Apr 30, 2006, 19:36
Social networks protect against Alzheimer's
Having close friends and staying in contact with family members offers a protective effect against the damaging effects of Alzheimer’s disease according to research by physicians at Rush University Medical Center in Chicago. The study, which is currently posted online in The Lancet Neurology, will be published in the May print edition of the journal.
Apr 23, 2006, 18:17
Severe cerebral congophilic angiopathy found in Camelford resident
A rare form of Alzheimer's disease has been discovered in a resident of Camelford, the town in south west England which bore the brunt of the accidental discharge of 20 tonnes of aluminium sulphate into the local water supply almost 20 years ago.
Apr 20, 2006, 16:11