XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
  Diabetes
   NIDDM
   Insulin Resistance
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 22nd, 2006 - 20:27:33

Insulin Resistance Channel
subscribe to Insulin Resistance newsletter

Latest Research : Endocrinology : Diabetes : Insulin Resistance

   DISCUSS   |   EMAIL   |   PRINT
Insulin resistance in early teens may predict diabetes
Aug 22, 2006, 20:26, Reviewed by: Dr. Sanjukta Acharya

"The finding indicates that the prevalence of atherosclerotic cardiovascular disease risk factors and type 2 diabetes (both of which are related to obesity and are increasing as today's children reach adulthood) also are related to insulin resistance independent from obesity."

 
The body's decreased response to insulin beginning as early as age 13 may mean increased cardiovascular disease risk by age 19, according to research reported in Hypertension: Journal of the American Heart Association.

The finding indicates that the prevalence of atherosclerotic cardiovascular disease risk factors and type 2 diabetes (both of which are related to obesity and are increasing as today's children reach adulthood) also are related to insulin resistance independent from obesity, said Alan R. Sinaiko, M.D., lead author of the study and professor of pediatrics at the University of Minnesota Medical School in Minneapolis. After screening blood pressure, height and weight in more than 12,000 5th through 8th grade students in Minneapolis public schools, 357 students (average age 13) were recruited for the study. Two-hundred twenty-four participants completed the study. The participants were 58 percent male and 83 percent white.

At baseline the children underwent a complete physical examination including measurements of blood pressure, height, weight, percentage of body fat, high density lipoprotein cholesterol (HDL-C), triglycerides and fasting insulin levels. The students were also categorized by stage of sexual development. Sinaiko and colleagues tracked insulin resistance with a series of insulin clamp studies first at age 13, then 15 and again at 19.

"The insulin clamp is considered the gold standard to measure insulin resistance, a precursor to type 2 diabetes," Sinaiko said. "Insulin regulates sugars, starches, fats and proteins in the body. When cells become resistant to the effects of insulin, insulin levels increase to regulate metabolism." This clamp technique infuses insulin and glucose into the blood and measures the resulting glucose and insulin levels. Those who require lower amounts of glucose, indicating lower uptake of glucose into muscle cells, were considered insulin resistant, he said.

The insulin clamp tests were repeated at age 15 on 309 participants and again at age 19 on 224 participants. Occurring together, insulin resistance, high blood pressure, low HDL-C, high triglycerides and obesity are defined as the metabolic or insulin resistance syndrome, which Sinaiko and other researchers say may trigger type 2 diabetes and atherosclerosis. Sinaiko said the correlation between insulin resistance at age 13 and age 19 was highly significant. Insulin resistance at age 13 predicted high systolic blood pressure, which is associated with risk of stroke, and high triglycerides at age 19. For every unit increase in insulin resistance there was a 0.41 millimeters of mercury (mm Hg) increase in systolic blood pressure and 1.91 milligrams per deciliter (mg/dl) increase in triglycerides. "This is the first study to show insulin resistance by itself is a significant predictor of cardiovascular disease, beginning in childhood," Sinaiko said.
 

- Hypertension: Journal of the American Heart Association
 

www.americanheart.org

 
Subscribe to Insulin Resistance Newsletter
E-mail Address:

 

Co-authors are: Julia Steinberger, M.D.; Antoinette Moran, M.D.; Ching-Ping Hong, M.A.; Ronald J. Prineas, M.D., Ph.D.; and David R. Jacobs Jr., Ph.D. The National Institutes of Health funded the study.

Statements and conclusions of study authors published in the American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect association policy or position. The American Heart Association makes no representation or warranty as to their accuracy or reliability.


Related Insulin Resistance News

Insulin resistance in early teens may predict diabetes
Race may be risk factor for insulin resistance
Elevation of fat-derived molecule RBP4 foretells early insulin resistance
Insulin Resistance Linked to Pancreatic Cancer
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of langerhans
Insulin Resistance May Be the Result of Mitochondrial Dysfunction


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us