XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
  Hypertension
  CAD
  Myocardial Infarction
  CHF
  Clinical Trials
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

CAD Channel
subscribe to CAD newsletter

Latest Research : Cardiology : CAD

   DISCUSS   |   EMAIL   |   PRINT
Clopidogrel Before Angioplasty Cuts in Half Risk of Death - PCI-CLARITY study
Sep 14, 2005, 02:17, Reviewed by: Dr.

“Patients undergoing PCI are routinely given clopidogrel after the procedure to help prevent complications. We found that starting treatment with clopidogrel before the procedure led to a significant reduction in the risk of cardiovascular death and ischemic complications following the angioplasty.”

 
A new study from Brigham and Women’s Hospital (BWH) finds that early use of clopidogrel, an oral antiplatelet medication, started prior to rather than at the time of angioplasty, reduces the odds of death, heart attack or stroke following the angioplasty by more than 45 percent. Results of the PCI-CLARITY study were presented by Marc S. Sabatine, MD, MPH, an associate physician in the Cardiovascular Division at BWH and an instructor in Medicine at Harvard Medical School (HMS) at the European Society of Cardiology (ESC) Congress 2005 in Stockholm, Sweden on September 3 – 7, 2005.

Earlier this year, Sabatine and colleagues at BWH published the results of CLARITY-TIMI 28 (Clopidogrel as Adjunctive Reperfusion Therapy – Thrombolysis in Myocardial Infarction) in the New England Journal of Medicine, demonstrating that clopidogrel helped open blocked arteries and decreased the odds of a second heart attack by 31 percent. Now, this group of researchers has found that the administration of clopidogrel before angioplasty offers profound protection against major complications.

Angioplasty, also known as percutaneous coronary intervention (PCI), is a procedure performed by cardiologists to relieve coronary narrowing. More than two million PCIs are performed each year worldwide, the majority of which involve insertion of a coronary stent to help keep the artery open. “Patients undergoing PCI are routinely given clopidogrel after the procedure to help prevent complications,” noted Sabatine. “We found that starting treatment with clopidogrel before the procedure led to a significant reduction in the risk of cardiovascular death and ischemic complications following the angioplasty.”

The PCI-CLARITY trial analyzed 1,863 patients with a recent heart attack that went on to undergo PCI. Within this group 933 had been randomized to receive clopidogrel (300 mg loading dose, then 75 mg once daily) and 930 had been randomized to receive placebo when they first presented to the hospital. Primary outcomes were death, recurrent heart attack or stroke from PCI to 30 days after randomization. After analyzing results, researchers found that clopidogrel pretreatment reduced the odds of death, recurrent heart attack or stroke by 46 percent. Pretreatment also reduced the odds of a recurrent heart attack or stroke while awaiting PCI by 38 percent. The researchers found that pretreatment was beneficial regardless of the patient’s age or sex or delay until the procedure. According to Christopher P. Cannon, MD the Principal Investigator of CLARITY-TIMI 28, an associate physician in the Cardiovascular Division at BWH and an associate professor of Medicine at HMS, “For every 23 patients we treated with clopidogrel before PCI, we prevented one major cardiovascular event. That is an amazingly big benefit that results from one to three extra doses of clopidogrel.”

“The rich data from CLARITY-TIMI 28 has shown us that clopidogrel is important in the treatment of heart attacks. Now we have direct evidence that it also helps reduce odds of death associated with angioplasty and stenting procedures,” said senior author BWH’s Eugene Braunwald, MD, HMS Distinguished Hersey Professor of Medicine and chairman of the TIMI Study Group. “I am proud that BWH continues to define the standard of care for heart attack patients around the world. I believe these results are an important contribution to how we treat patients with coronary artery disease.”

 

- The results were published simultaneously in the Journal of the American Medical Association online on September 4, 2005 and then in print in the September 14, 2005 issue.
 

www.brighamandwomens.org

 
Subscribe to CAD Newsletter
E-mail Address:

 

The CLARITY-TIMI 28 trial was supported by a grant from Sanofi-Aventis and Bristol-Myers Squibb.

Brigham and Women’s Hospital
BWH is a 755-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare System, an integrated health care delivery network. Internationally recognized as a leading academic health care institution, BWH is committed to excellence in patient care, medical research and the training and education of health care professionals. The hospital’s preeminence in all aspects of clinical care is coupled with its strength in medical research. A leading recipient of research grants from the National Institutes of Health, BWH conducts internationally acclaimed clinical, basic and epidemiological studies. For more information about BWH, please visit: www.brighamandwomens.org.


Related CAD News

Genetic Regulator for Coronary Artery Smooth Muscle Cells Identified
New Risk Factors Do Not Improve Assessment Of Coronary Heart Disease Risk
Angioplasty: door-to-balloon time matters regardless of time to presentation
ESC Updated Guidelines for Stable Angina Pectoris Management
Antioxidant Selenium Offers No Heart-Disease Protection
Coffee not linked with coronary heart disease
Adding abciximab to the antithrombotic regimen significantly reduces post-stent complications
Stenting just the left main stem gives equivalent results
Serotonin may play role in hardening of the arteries
Severe Heart Disease, Poor Prognosis Linked To Erectile Dysfunction


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us