XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
  Hypertension
   Pulmonary Hypertension
  CAD
  Myocardial Infarction
  CHF
  Clinical Trials
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

The Trial of Preventing Hypertension (TROPHY)

Hypertension Channel
subscribe to Hypertension newsletter

Latest Research : Cardiology : Hypertension

   DISCUSS   |   EMAIL   |   PRINT
TROPHY Trial: Incidence of hypertension reduced with early intervention
Mar 22, 2006, 07:05, Reviewed by: Dr. Sanjukta Acharya

"We've typically waited until people have hypertension before we treated them, and it's really hard to stave off the disease's progression when you treat it later in its development. This is an opportunity for us to investigate early treatments and to see if we can prevent patients from having to be on life-long therapy for hypertension."

 
Treating pre-hypertension with medication and lifestyle modifications reduces the risk of patients progressing to hypertension, a new study involving researchers at UT Southwestern Medical Center has concluded.

The findings, appearing in an upcoming issue of The New England Journal of Medicine, are the result of a four-year study of more than 800 patients who had a condition known as pre-hypertension. A blood pressure between 120 and 139 mm Hg systolic and 80 to 89 mm Hg diastolic indicates pre-hypertension.

"The recommended guidelines currently list lifestyle modifications for treatment of pre-hypertension," said Dr. Shawna Nesbitt, associate professor of internal medicine at UT Southwestern and an author on the study. "But the long-term maintenance of a lifestyle change is dismal. Patients typically don't stick to it."

Present guidelines recommend that pre-hypertension be managed with changes in the patient's lifestyle through weight loss, salt restriction, exercise and dietary modification. Despite intense efforts to keep patients from developing hypertension, an increasing number of people are diagnosed each year. Hypertension is one of the leading causes of other cardiovascular ailments, including heart disease and stroke.

Dr. Nesbitt collaborated with researchers at several institutions to find out if treatment with angiotensin-receptor blockers, or ARBs, could prevent the development of hypertension. This is the first human study involving treatment of prehypertension with an ARB.

"We chose to administer a low dose of the ARB medication candesartan cilexetil because it has qualities that suggest it changes characteristics of the blood vessel an effect that may be maintained beyond the period of treatment," Dr. Nesbitt said. "As hypertension develops, the walls of the blood vessels actually get thicker, setting the stage for high blood pressure to propagate. This medication and others like it seem to decrease that thickness and improve the function of the blood vessels."

In the study, patients between the ages of 30 and 65 with blood pressures between 130 and 139 mm Hg systolic and 85 to 89 mm Hg diastolic were treated over a four-year period with either a placebo or with ARB medications.
"In a prior study, it was shown that over four years, if left untreated, 40 percent of people with prehypertension become hypertensive," Dr. Nesbitt said.

Half of the participants were given candesartan cilexetil for two years and then were removed from the medication for two years; the other half of the group was untreated for the four years. Even up to two years after treatment was stopped, the candesartan-treated pre-hypertensive patients had a 15.8 percent lower risk of developing hypertension compared with untreated pre-hypertensive patients. Both groups were advised to modify their diet and exercise habits.

"I think this is the tip of the iceberg in the further study of new treatment protocols for pre-hypertension" Dr. Nesbitt said. "We've typically waited until people have hypertension before we treated them, and it's really hard to stave off the disease's progression when you treat it later in its development. This is an opportunity for us to investigate early treatments and to see if we can prevent patients from having to be on life-long therapy for hypertension."
 

- The New England Journal of Medicine
 

www.utsouthwestern.edu

 
Subscribe to Hypertension Newsletter
E-mail Address:

 

The Trial of Preventing Hypertension, or TROPHY, is a four-year, multicenter study, which was investigator-*initiated and financially supported by pharmaceutical company AstraZeneca LP, manufacturer of the candesartan cilexetil drug Atacand.

Dr. Nesbitt is an executive committee member of the TROPHY study. Other authors also members of the executive committee are from the University of Michigan Medical School, the Medical University of South Carolina, the State University of New York Downstate Medical Center, Rush University Medical Center, Hennepin County Medical Center in Minneapolis, St. Luke's-Roosevelt Hospital Center, and the University of Alabama at Birmingham.


Related Hypertension News

Uric acid levels closely related to hypertension in Blacks
Is TROPHY misleading?
High blood pressure induces low fat metabolism in heart muscle
Beta Blockers No More First Choice for Hypertension
Job stress does not raise blood pressure
Blood Pressure Readings Lower when Patients Slow Down
Promising evidence of new drug therapies in Pulmonary arterial hypertension (PAH)
Fewer hours of sleep could lead to hypertension
Loneliness linked to high blood pressure in aging adults
Grape seed extract may be effective in reducing blood pressure


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us