XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
  Dialysis
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Nov 17th, 2006 - 22:35:04

Nephrology Channel
subscribe to Nephrology newsletter

Latest Research : Nephrology

   DISCUSS   |   EMAIL   |   PRINT
BMP-7 Prevents Renal Osteodystrophy and Vascular Calcification Associated with Chronic Renal Disease
Mar 13, 2005, 08:26, Reviewed by: Dr.

Patients with chronic kidney disease or end-stage kidney disease experience a number of serious metabolic disorders that are associated with the loss of kidney function.

 
Curis, Inc. highlighted that the recent online issue of the Journal of the American Society of Nephrology contains a preclinical report demonstrating that treatment with BMP-7, a signaling protein that was discovered by scientists from Curis, results in amelioration of two major complications of chronic kidney disease.

The United States Renal Data System estimates that there are currently 423,000 patients in the U.S. with end-stage kidney disease and many more with various stages of chronic kidney disease.

Patients with chronic kidney disease or end-stage kidney disease experience a number of serious metabolic disorders that are associated with the loss of kidney function. Some of these disorders, such as severe anemia, have effective therapeutic treatments, such as erythropoietin.

Other kidney-disease-related disorders, including renal osteodystrophy (a collective name for several forms of metabolic bone disease) and vascular calcification (a form of cardiovascular disease that involves mineralization of the blood vessels), have proven much more difficult to treat successfully.

Cardiovascular mortality in patients with chronic kidney disease is extremely high.

The current report, entitled "Low Turnover Osteodystrophy and Vascular Calcification are Amenable to Skeletal Anabolism in an Animal Model of Chronic Kidney Disease and the Metabolic Syndrome," is authored by researchers from the Washington University School of Medicine in St. Louis, Missouri.

The investigators demonstrate that BMP-7 treatment prevents renal osteodystrophy and vascular calcification by stimulating the rate of skeletal mineralization, thereby diverting mineral that might have been deposited inappropriately in the blood vessels.
 

- Online issue of the Journal of the American Society of Nephrology
 

Curis, Inc.

 
Subscribe to Nephrology Newsletter
E-mail Address:

 

Curis, Inc. is a therapeutic drug development company. The Company's technology focus is on regulatory pathways that control repair and regeneration. Curis' product development involves the use of proteins or small molecules to modulate these pathways. Curis has successfully used this technology and product development approach to produce several promising drug product candidates in the fields of cancer (under partnership with Genentech, which also includes a co-development collaboration between Curis and Genentech for a basal cell carcinoma product candidate), kidney disease (licensed to Ortho Biotech, a subsidiary of Johnson & Johnson), neurological disorders (partnered with Wyeth Pharmaceuticals), hair growth, and cardiovascular disease. For more information, please visit the Curis web site.



Related Nephrology News

Kidney stones? Have some orange juice!!!
NOTCH2 gene mutations linked to Alagille syndrome
Fetal hydronephrosis mystery solved
Alport Syndrome: From Pathogenesis to a Potential Therapy
Meckel-Gruber syndrome gene identified- a help to understand polycystic kidney disease
Dialysis patients may be overmedicated
Mycophenolate mofetil may be more effective in inducing lupus nephritis remission
Dialysis patients often have close family members also on dialysis - Study
Prognosis Improving For Diabetics With End Stage Renal Disease
Osmolytes critical to survival of kidney cells


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us