XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 Latest Research
 Infectious Diseases
 Respiratory Medicine
  Cystic Fibrosis
 Public Health
 Clinical Trials
 Medical News
 Awards & Prizes
 Special Topics
 Odd Medical News
 World News

Last Updated: Aug 19th, 2006 - 22:18:38

Asthma Channel
subscribe to Asthma newsletter

Latest Research : Respiratory Medicine : Asthma

   DISCUSS   |   EMAIL   |   PRINT
CD23 structure revealed by NMR spectroscopy
Sep 21, 2005, 19:22, Reviewed by: Dr.

‘This is an important step forward in understanding some of the underlying mechanisms of the allergic response. Our next challenge is to develop the therapeutic potential of this information’

The structure of a molecule that regulates levels of the key antibody involved in allergic reactions and asthma, IgE, has been revealed by researchers from Oxford University and King’s College London. The study, published in Journal of Experimental Medicine, will help in the discovery of drugs to treat these two conditions.

IgE is thought to make certain cells of the immune system (mast cells) more sensitive to allergens, so lowering circulating levels of active IgE is a possible way of reducing the symptoms of allergies or allergic asthma.

The low-affinity receptor for IgE, called CD23, plays a dual role in the production of IgE. It can either inhibit or stimulate the antibody’s production, depending whether it is attached or detached from the cell membrane.

Small molecules that bind to CD23 and prevent it from stimulating IgE production could be potential allergy and asthma treatments.

The researchers at Oxford and King’s used nuclear magnetic resonance (NMR) spectroscopy to discover the structure of CD23. Professor Brian Sutton from King’s, a co-researcher on the study, said: ‘Currently a therapy that blocks IgE functioning is available, but it is expensive. Drugs that prevent the production of IgE might be a much cheaper way of treating allergies. Dr James McDonnell from Oxford University, who led the study, said: ‘This is an important step forward in understanding some of the underlying mechanisms of the allergic response. Asthma UK funded part of the work. Dr Lyn Smurthwaite, their Research Development Manager said: ‘The development of new therapies for people with asthma is an important part of Asthma UK’s research programme'.

- ‘The structure of human CD23 and its interactions with IgE and CD21’ by Richard G Hibbert, Peter Teriete, Gabrielle J Grundy, Rebecca L Beavil, Rajko Reljic, V Michael Holers, Jonathan P Hannan, Brian J Sutton, Hannah J Gould and James M McDonnell is published in the 19 September edition of Journal of Experimental Medicine, 202(6): 751-760.


Subscribe to Asthma Newsletter
E-mail Address:


Asthma UK is the charity dedicated to improving the health and well-being of the 5.2 million people in the UK whose lives are affected by asthma. For up-to-date news on asthma, information and publications, visit the Asthma UK website www.asthma.org.uk.

Related Asthma News

A dog in home may worsen asthma in children
PEAK Trial: Inhaled steroids do not prevent chronic asthma
Telithromycin antibiotic could help in asthma attack
Tomatoes, carrots can cut asthma risk
Inhaled steroid may work better for normal-weight people
Female foetus could increase expectant woman's asthma
Childhood Asthma Affecting More than Just Breathing
Omalizumab has long-term benefits in severe allergic asthma
CD23 structure revealed by NMR spectroscopy
Bacteria in Household Dust May Trigger Asthma

For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page


© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us