XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
  Parkinson's
   Rotenone
  Dementia
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Nov 17th, 2006 - 22:35:04

Parkinson's Channel
subscribe to Parkinson's newsletter

Latest Research : Aging : Parkinson's

   DISCUSS   |   EMAIL   |   PRINT
Transplantation of monkey embryonic stem cells reverses Parkinson disease in primates
Jan 4, 2005, 19:28, Reviewed by: Dr.



 
The replenishment of missing neurons in the brain as a treatment for Parkinson disease reached the stage of human trials over 15 years ago, however the field is still in its infancy. Researchers from Kyoto University have now shown that dopamine-producing neurons (DA neurons) generated from monkey embryonic stem cells and transplanted into areas of the brain where these neurons have degenerated in a monkey model of Parkinson disease, can reverse parkinsonism. Their results appear in the January 3 issue of the Journal of Clinical Investigation.

Studies of animal models of Parkinson disease as well as clinical investigations, have shown that transplantation of fetal DA neurons can relieve the symptoms this disease. However the technical and ethical difficulties in obtaining sufficient and appropriate donor fetal brain tissue have limited the application of this therapy.

These researchers previously demonstrated that mouse embryonic stem cells can differentiate into neurons when cultured under specific conditions. These same culture conditions, technically simple and efficient, were recently applied to primate embryonic stem cells and resulted in the generation of large numbers of DA neurons. In their current JCI study, Jun Takahashi and colleagues generated neurons from monkey embryonic stem cells and exposed these cells to FGF20, a growth factor that is produced exclusively in the area of the brain affected by Parkinson disease and is reported to have a protective effect on DA neurons. The authors observed increased DA neuron development and subsequently transplanted these neurons into monkeys treated with an agent called MPTP, which is considered a primate model for Parkinson disease. These transplanted cells were able to function as DA neurons and diminished Parkinsonian symptoms.

In an accompanying commentary, J. William Langston from the Parkinson's Institute, California, describes this study as a milestone in the development of stem cell technology but cautions that while the observations are encouraging, the reported number of surviving DA neurons was very low, only 13% of the cells surviving, well below the estimated number of DA neurons that survive after fetal cell transplants (approximately 10%). While this may be a difference observed between transplantation in monkeys and humans, Langston stresses that it may be necessary for far more DA neurons to survive and for that survival to be long lasting in order to render this approach as a useful therapy in humans.

Langston highlights that "clearly the study reported here will advance research aimed at validating the use of stem cells to treat neurodegenerative disease" and this is most welcome particularly as investigators face yet another presidential moratorium endeavoring to limit the number of human stem cell lines that can be used for future research and treatment.
 

- January 3 issue of the Journal of Clinical Investigation
 

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/94.

 
Subscribe to Parkinson's Newsletter
E-mail Address:

 

TITLE: Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model

AUTHOR CONTACT: Jun Takahashi
Kyoto University Graduate School of Medicine, Kyoto, Japan.
Phone: 81-75-751-3450; Fax: 81-75-752-9501; E-mail: [email protected]

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/102.

ACCOMPANYING COMMENTARY:

TITLE: The promise of stem cells in Parkinson disease

AUTHOR CONTACT: J. William Langston
Parkinson's Institute, Sunnyvale, California, USA.
Phone: 408-734-2800; Fax: 408-734-8522; E-mail: [email protected]

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/23.


Related Parkinson's News

Laser probe of a brain pigment's anatomy may offer insight into Parkinson's disease
Novel blood test for early detection of Parkinson's, receives national recognition
New genetic model for Parkinson's disease
Expertise In Brain Stimulation Therapy May Improve Outcomes in Parkinson's Disease
Pesticide Dieldrin Linked to Increased Risk of Parkinson's Disease
ER trafficking defect caused by alpha-synuclein accumulation implicated in Parkinson's
Pesticides exposure associated with Parkinson's disease
Tuberculosis drug PAS may cure Parkinson's-like illness
Stabilizing microtubules with L-AP4 reduces rotenone toxicity
New Guidelines Improve Diagnosis and Quality of Life for People with Parkinson Disease


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us