XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
  Parkinson's
   Rotenone
  Dementia
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

Parkinson's Channel
subscribe to Parkinson's newsletter

Latest Research : Aging : Parkinson's

   DISCUSS   |   EMAIL   |   PRINT
Turning off a mutation linked to Parkinson's disease
Jan 19, 2006, 15:54, Reviewed by: Dr. Priya Saxena

"It may also be useful for other diseases of the brain, such as dementia with Lewy bodies, a disease also characterized by Lewy bodies in the brain"

 
A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease.

The gene therapy, described in the January online issue of the journal Experimental Neurology, was designed by Martha Bohn and her laboratory group at Northwestern University Feinberg School of Medicine.

Bohn is Medical Research Council Professor and director of the neurobiology program at Children's Memorial Research Center and professor of pediatrics and of molecular pharmacology and biological chemistry at the Feinberg School. The gene technique the Bohn lab developed removes a protein known as alpha-synuclein from the diseased dopamine-producing neurons that die in Parkinson's disease. Alpha-synuclein is abundant in structures known as Lewy bodies a diagnostic hallmark of Parkinson's disease.

Research has shown that mutant forms of the alpha-synuclein gene, as well as too much alpha- synuclein protein, are involved in the development Parkinson's disease in some families.

For this research, the Bohn lab combined a recently developed technology called "RNA interference" with gene therapy to turn off alpha-synuclein in dopamine neurons. RNA interference is a sophisticated method to selectively turn off one gene in a cell, leaving others unaffected.

By placing the RNA interference into a crippled, non-disease-causing virus, scientists in the Bohn lab have been able to deliver the RNA interference tool to the brain of rats and turn off the alpha-synuclein protein in neurons. "This is the first step in developing a new therapy for Parkinson's disease based on molecular knowledge of the disease," said Mohan K. Sapru, research assistant professor of pediatrics, who is first author on the study and co-inventor of the gene therapy technology.

"It may also be useful for other diseases of the brain, such as dementia with Lewy bodies, a disease also characterized by Lewy bodies in the brain," Sapru said.

The Bohn lab will subsequently test this gene therapy in mouse models of the disease. If the RNA interference approach works in the mouse, a gene therapy based on silencing the _alpha-synuclein gene will be developed for clinical trials for Parkinson's patients.
 

- January online issue of the journal Experimental Neurology
 

www.northwestern.edu

 
Subscribe to Parkinson's Newsletter
E-mail Address:

 

Other researchers on this study were Jonathan W. Yates; Shea Hogan; Lixin Jiang; and Jeremy S. Halter, Feinberg School.

This work was supported by the Parkinson's Disease Foundation; National Institutes of Health grant NS31957; the State of Illinois Excellence in Academic Medicine Program; and the Medical Research Institute Council of Children's Memorial Hospital.


Related Parkinson's News

Laser probe of a brain pigment's anatomy may offer insight into Parkinson's disease
Novel blood test for early detection of Parkinson's, receives national recognition
New genetic model for Parkinson's disease
Expertise In Brain Stimulation Therapy May Improve Outcomes in Parkinson's Disease
Pesticide Dieldrin Linked to Increased Risk of Parkinson's Disease
ER trafficking defect caused by alpha-synuclein accumulation implicated in Parkinson's
Pesticides exposure associated with Parkinson's disease
Tuberculosis drug PAS may cure Parkinson's-like illness
Stabilizing microtubules with L-AP4 reduces rotenone toxicity
New Guidelines Improve Diagnosis and Quality of Life for People with Parkinson Disease


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us