XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
  Memory
  Regeneration
  Stroke
  Brain Diseases
  Headache
  Spinal Cord Diseases
  Demyelinating Diseases
  Neurodegenerative Diseases
   Rett Syndrome
  Taste
  Trigeminal Neuralgia
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

Neurodegenerative Diseases Channel
subscribe to Neurodegenerative Diseases newsletter

Latest Research : Neurosciences : Neurodegenerative Diseases

   DISCUSS   |   EMAIL   |   PRINT
Nitration Linked to Oxidative Stress Related Damage in Neurodegenerative Disorders
Jun 29, 2006, 02:43, Reviewed by: Dr. Priya Saxena

"Our study certainly suggests that the sensitivity of certain proteins to peroxynitrite is an early contributor to neurodegeneration, but other factors may also be involved,"

 
Parkinson's, Alzheimer's, Lou Gehrig's disease and other brain disorders are among a growing list of maladies attributed to oxidative stress, the cell damage caused during metabolism when the oxygen in the body assumes ever more chemically reactive forms.

But the precise connection between oxidation and neurodegenerative diseases has eluded researchers. Now, a study by the Department of Energy's Pacific Northwest National Laboratory and UCLA's David Geffen School of Medicine reveals that damage is linked to a natural byproduct of oxidation called nitration.

"We looked at a healthy brain and found nitration of proteins that are implicated in neurodegenerative disease," said Colette Sacksteder, PNNL scientist and lead author of the study, published in the July issue of the journal Biochemistry (online Wed., June 28). PNNL scientist Wei-Jun Qian was co-lead author.

The results are from the most detailed proteomic analysis of a mammalian brain to date that is, a survey of nearly 8,000 different, detectable proteins in the mouse brain. The research suggests that many neurodegenerative diseases leave a biochemical calling card, or biomarker, that could be used to predict the earliest stages of brain impairment. Many biomedical researchers believe that detecting disease states before symptoms occur is the key to reversing many as-yet-incurable diseases.

The biomarker is known as nitrotyrosine, made when an amino acid in the brain, tyrosine, is in the presence of an oxidative-stress molecule called peroxynitrate. The biomarker was found on 31 sites along 29 different proteins, half of which had been previously implicated in several of the neurodegenerative diseases.

"Our study certainly suggests that the sensitivity of certain proteins to peroxynitrite is an early contributor to neurodegeneration, but other factors may also be involved," said Diana Bigelow, PNNL staff scientist and the paper's corresponding author. "The next step, of explicitly looking at tissues with neurodegenerative disease, will test this hypothesis."
 

- July issue of the journal Biochemistry (online Wed., June 28)
 

www.pnl.gov

 
Subscribe to Neurodegenerative Diseases Newsletter
E-mail Address:

 

The study was made possible by a specially modified mass spectrometer at PNNL, housed at the W.R. Wiley Environmental Molecular Sciences Laboratory. The instrument, designed and operated by a group led by co-author and Richard D. Smith, a Battelle Fellow, separates and identifies proteins with unprecedented precision. Bigelow and colleagues supported the results with standard molecular biology techniques. The study was funded by the National Institutes of Health and PNNL.

PNNL is a DOE Office of Science laboratory that solves complex problems in energy, national security, the environment and life sciences by advancing the understanding of physics, chemistry, biology and computation. PNNL employs 4,200 staff, has an annual budget of more than $725 million, and has been managed by Ohio-based Battelle since the lab's inception in 1965.


Related Neurodegenerative Diseases News

3-D forms link antibiotic resistance and pantothenate kinase associated neurodegeneration
New biomarkers could help doctors spot neurodegenerative diseases
Nitration Linked to Oxidative Stress Related Damage in Neurodegenerative Disorders
REM sleep disorders can indicate early neurodegeneration
Neurodenegerative diseases mechanisms linked to transport proteins
New Tools Developed for Studying Neurodegenerative Brain Disorders
New Tools Developed for Studying Neurodegenerative Brain Disorders
Research Suggests Abraham Lincoln Suffered from Spinocerebellar Ataxia type 5 (SCA5)
Discovery may improve treatment of neurodegenerative diseases
Possible molecular origin of nervous system degeneration diseases


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us