XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
  Infertility
   Letrozole
  Menstruation Disturbances
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

Infertility Channel
subscribe to Infertility newsletter

Latest Research : Gynaecology : Infertility

   DISCUSS   |   EMAIL   |   PRINT
Dopamine agonist can prevent ovarian hyperstimulation syndrome
Jun 22, 2006, 05:07, Reviewed by: Dr. Priya Saxena

"We knew that dopamine and its agonists also reverse increased VP in hyperstimulated animals, so we decided to see whether it could prevent OHSS in women undergoing ovarian stimulation for ART."

 
A class of drug widely used in a number of gynaecological conditions can prevent ovarian hyperstimulation syndrome (OHSS), an infrequent but serious complication of assisted reproduction treatments, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic, on Wednesday 21 June 2006. Dr. Claudio Alvarez, from the Instituto Valenciano de Infertilidad, Valencia, Spain, said that his team's work, using the dopamine agonist cabergoline, was the first successful attempt to prevent this disorder.

OHSS can occur when drugs are used to stimulate the ovaries to produce the eggs needed for fertilization in IVF treatment. The ovaries become larger than normal, and there can be a build-up of fluid in the abdomen. In severe cases there may also be hemoconcentration (decrease of the fluid content of the blood, with a resulting increase in its concentration), and kidney and liver damage; this can be life-threatening. Although OHSS has been known for many years, until now it has been treated empirically and the underlying causes have been little understood.

Animal models had shown that increased vascular permeability (VP), a factor in OHSS, was associated with an increased expression in the ovary of vascular endothelial growth factor (VEGF), responsible for the growth of blood vessels. The binding of VEGF to its receptor VEGFR2 increases VP. "We knew that dopamine and its agonists also reverse increased VP in hyperstimulated animals", said Dr. Alvarez, "so we decided to see whether it could prevent OHSS in women undergoing ovarian stimulation for ART."

Dopamine agonists are widely used in gynaecological conditions, especially in patients with hyperprolactinemia - a condition where the presence of abnormally high levels of the hormone, prolactine, can cause a number of disorders affecting fertility and their safety record is good. So Dr. Alvarez and his team began a study of 54 egg donors, who were randomly allocated into two groups immediately after administration of human chorionic gonadotropin (hCG), a drug used to induce ovulation.

The study group received 0.5 mg of the dopamine agonist cabergoline and the control group took placebo. The women were monitored every 48 hours from day 0 (the day hCG was given) to day 8. There were significant differences between the two groups.

"We found that cabergoline reduced hemoconcentration, ascites (excess fluid in the space between the membranes lining the abdomen and abdominal organs) and the incidence of moderate to severe OHSS in women at risk," said Dr. Alvarez. "Our next move will be to study the action of dopamine agonists in more detail, and to proceed to bigger studies of their effects in clinical trials. We hope that our work will enable us to better understand the mechanism of development of this serious complication of ART treatment, and to be able to treat it effectively."
 

- 22nd annual conference of the European Society of Human Reproduction and Embryology
 

www.eshre.com

 
Subscribe to Infertility Newsletter
E-mail Address:

 



Related Infertility News

Spermatogonial stem cells could aid male infertility
Dopamine agonist can prevent ovarian hyperstimulation syndrome
CBT can restore ovulation in infertile women
New method of testing ova for abnormalities
New Hope For Preserving Future Fertility
How IVF could be causing genetic errors in embryos
Fertility drug letrozole given 'all-clear' in new study
Major birth defect risk more for IVF babies
Treatment of Men with ED Improves Women's Sexual Function
Fertility awareness-based methods of family planning & timing - Study


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us