XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
  Depression
  Neuropsychiatry
  Personality Disorders
  Bulimia
  Anxiety
   Phobia
   Panic Disorders
   Stress
   PTSD
   GAD
   Agoraphobia
   OCD
   Social Phobia
  Substance Abuse
  Suicide
  CFS
  Psychoses
  Child Psychiatry
  Learning-Disabilities
  Psychology
  Forensic Psychiatry
  Mood Disorders
  Sleep Disorders
  Peri-Natal Psychiatry
  Psychotherapy
  Anorexia Nervosa
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

OCD Channel
subscribe to OCD newsletter

Latest Research : Psychiatry : Anxiety : OCD

   DISCUSS   |   EMAIL   |   PRINT
OCD has multiple genetic associations
Jun 8, 2006, 05:30, Reviewed by: Dr. Ankush Vidyarthi

"OCD once was thought to be primarily psychological in origin. But now there is growing evidence that there is a genetic basis behind OCD, which will help us better understand the condition,"

 
A federally funded team of researchers including several from Johns Hopkins have identified six regions of the human genome that might play a role in susceptibility to obsessive compulsive disorder, or OCD. The study was published online June 6 in Molecular Psychiatry.

"OCD once was thought to be primarily psychological in origin," says Yin Yao Shugart, Ph.D., statistical geneticist and associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health. "But now there is growing evidence that there is a genetic basis behind OCD, which will help us better understand the condition," she says.

OCD is characterized by intrusive and senseless thoughts and impulses that together are defined as obsessions, as well as repetitive and intentional behaviors, referred to as compulsions. OCD is estimated to affect up to 3 percent of the American population.

In what the research team describes as the first whole-genome scan to look for genetic "markers" or similarities in the genomes of people with OCD, results identified six potentially significant regions in the genome, which lie on five different chromosomes that appear "linked" to OCD. It's likely that any genes directly associated OCD are to be found in these regions.

"We've long suspected that, rather than being caused by a single gene, OCD has multiple genetic associations," says Jack Samuels, Ph.D., an epidemiologist and assistant professor of psychiatry at the Johns Hopkins School of Medicine.

To conduct the study, the researchers collected blood samples from 1,008 individuals from a total of 219 families in which at least two siblings were clinically diagnosed with OCD.

DNA from each sample was analyzed by the Hopkins Center for Inherited Disease Research (CIDR) using both molecular biology and statistical analysis computer programs. Specific DNA sequences known as genetic markers on chromosomes 1, 7, 6, and 15 and two markers on chromosome 3 appear more frequently in the patients with OCD than in those without it. The researchers want to further analyze the genetic regions they identified in this report and use more markers to possibly narrow down these regions to identify OCD risk genes.

The researchers suggest that whatever genes are found don't directly cause OCD but increase risk for it in conjunction with other genes or environmental factors.

"OCD is a relative newcomer to these genetic linkage studies," says Shugart, "so it's extremely important to follow up these findings by looking at more families and using more markers to assess the role of gene-environment interactions in OCD. "We are also very interested in finding genes underlying the different subtypes of OCD," she says.

Careful genetic analysis of different clinical categories of OCD has been limited by currently existing computer programs used in analyzing this type of data. The vast amount of data used in whole-genome analysis requires fine-tuned statistical calculations. The research team is eager to develop new methods in this area. "We predict that such findings may have immediate clinical implications for OCD patients," says Shugart.
 

- June 6 in Molecular Psychiatry
 

www.hopkinsmedicine.org/ocd/default.asp

 
Subscribe to OCD Newsletter
E-mail Address:

 

The researchers were funded by the National Institute of Mental Health, the National Institutes of Health, and the Johns Hopkins Bloomberg School of Public Health.

Authors on the paper are: Y.Y. Shugart, J. Samuels, V.L. Willour, M.A. Grados, Y. Wang, B. Cullen, R. Hoehn-Saric, D. Valle, K.-Y. Liang, M.A. Riddle and G. Nestadt, all of Hopkins; B.D. Greenberg, A. Pinto and S.A. Rasmussen of Brown Medical School; J.A. Knowles, A.J. Fyer and J. Page of the College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute; M.T. McCracken and J. Piacentini of the School of Medicine at University of California Los Angeles; S.L. Rauch and D.L. Pauls of Massachusetts General Hospital and Harvard Medical School; and D.L. Murphy of the National Institutes of Mental Health at the National Institutes of Health.


Related OCD News

Men, women have similar rates of compulsive buying
Kids with OCD bullied more than others
OCD has multiple genetic associations
Riluzole eases obsessive-compulsive symptoms


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us