XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
  Breast
  Skin
   Melanoma
  Blood
  Prostate
  Liver
  Colon
  Thyroid
  Endometrial
  Brain
  Therapy
  Risk Factors
  Esophageal
  Bladder
  Lung
  Rectal Cancer
  Pancreatic Cancer
  Bone Cancer
  Cervical Cancer
  Testicular Cancer
  Gastric Cancer
  Ovarian Cancer
  Nerve Tissue
  Renal Cell Carcinoma
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Nov 17th, 2006 - 22:35:04

Melanoma Channel
subscribe to Melanoma newsletter

Latest Research : Cancer : Skin : Melanoma

   DISCUSS   |   EMAIL   |   PRINT
Clinical Trials Tests CpG7909 and Melan-A Combination Melanoma Cancer Vaccines
Mar 18, 2005, 16:38, Reviewed by: Dr.

It was observed that the majority of T-cell responses developed rapidly with T-cell frequencies peaking seven to ten days after vaccination.

 
Results from the first Phase 1 clinical trial of a vaccine composed of a synthetic bacterial sequence, CpG7909 (ProMune TM , Coley Pharmaceuticals), and a melanoma antigen, Melan-A, indicate that this vaccine combination is not only safe but also can improve and bolster immune responses to tumors.

Lead authors and members of the Cancer Vaccine Collaborative, Drs. Daniel E. Speiser and Pedro Romero and their team from the Lausanne Branch of the Ludwig Institute for Cancer Research at the Lausanne University Hospital, Lausanne, Switzerland, reported their promising findings in The Journal of Clinical Investigation. In the clinical trial, the eight melanoma patients who each received four monthly injections of the vaccination all exhibited a strong antigen-specific T-cell response, with a rapid increase in the frequency of Melan-A specific T cells.

These T-cell clones recognize and kill melanoma cells in an antigen-specific manner. It was observed that the majority of T-cell responses developed rapidly with T-cell frequencies peaking seven to ten days after vaccination. Future studies will explore if increased doses of CpG7909 and/or peptides can further enhance the observed T-cell activation.
 

- The Journal of Clinical Investigation
 

http://www.jci.org/

 
Subscribe to Melanoma Newsletter
E-mail Address:

 



Related Melanoma News

Listening to the sound of skin cancer
Malignant melanoma cells secrete a potent embryonic growth factor
New mouse model technology in Melanoma vaccine tool-box
Malignant melanoma cells reprogrammed !
New option for patients with metastatic melanoma
Positive family history increases risk of multiple primary melanomas
Role of Slug Gene in Melanoma Metastasis Identified
Incidence Of Nonmelanoma Skin Cancer On The Rise Among Young Adults
Curcumin - Potent turmeric spice blocks growth of melanoma
MITF master regulator is the target of gene amplification in melanoma


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us