XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
  Breast
  Skin
  Blood
  Prostate
  Liver
  Colon
  Thyroid
  Endometrial
  Brain
  Therapy
  Risk Factors
  Esophageal
  Bladder
  Lung
  Rectal Cancer
  Pancreatic Cancer
  Bone Cancer
  Cervical Cancer
  Testicular Cancer
  Gastric Cancer
  Ovarian Cancer
  Nerve Tissue
  Renal Cell Carcinoma
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Nov 17th, 2006 - 22:35:04

Thyroid Channel
subscribe to Thyroid newsletter

Latest Research : Cancer : Thyroid

   DISCUSS   |   EMAIL   |   PRINT
Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer
Jan 4, 2005, 19:18, Reviewed by: Dr.



 
Cincinnati University scientists studying papillary thyroid cancer in Chernobyl residents following the 1986 nuclear plant accident have identified a novel genetic mutation event that occurs as a result of their exposure to high levels of radioiodide.

Yuri E. Nukiforov led a team of researchers from both Cincinnati University and the University of Munich in identifying a novel oncogene (a mutated and/or overproduced version of a normal gene that alone or together with other changes can convert a cell into a tumor cell) in papillary thyroid carcinomas that developed in patients exposed to radiation at Chernobyl. Their results are published in the January 3 issue of the Journal of Clinical Investigation.

Mutations of the genes BRAF, RET, or RAS are found in 70% of all cases of papillary thyroid tumors. In sporadic tumors (where patients have not been exposed to high levels of radiation), the most common genetic mutational event occurs within the BRAF gene. In contrast, mutations observed in radiation-induced tumors most commonly involve fusion of one end of the RET gene to the opposite end of various other genes to create a "chimeric oncogene." The two most common gene rearrangement types are called RET/PTC1 and RET/PTC3. Both types of mutations promote transformation of normal cells into malignant cells.

In their current study, Nukiforov and colleagues identified a novel oncogene in Chernobyl residents with papillary thyroid cancer. This oncogene resulted from fusion of part of the AKAP9 gene with one end of the BRAF gene; both genes are present within chromosome 7. The intrachromosomal AKAP9-BRAF fusion event resulted in the loss of portions of the BRAF protein that normally inhibit the kinase activity of BRAF. BRAF is then able to transmit uncontrolled signals to normal cells that promote their division and transformation into malignant tumor cells.

In an accompanying commentary, Alfredo Fusco and colleagues from Università degli Studi di Napoli "Federico II", in Naples, state that this study "provides further evidence supporting the concept that chromosomal inversions represent the most typical molecular lesion in tumors occurring in Belarus and the surrounding region after the Chernobyl accident….the peculiar susceptibility of thyroid follicular cells to chromosomal rearrangement is remarkable."

This study represents a major breakthrough in our knowledge of the genetic events involved in papillary thyroid initiation. It demonstrates that while BRAF activation is a common feature of both sporadic and post-Chernobyl thyroid cancers, it is the genetic event underlying BRAF activation that can differentiate between the two types of tumors, with a higher proportion of point mutations occurring in sporadic thyroid cancers and intrachromosomal inversion responsible for a larger percentage of radiation-induced tumors. At this stage, the signaling pathway activated as a result of these mutational events (known as the MAPK pathway) is the most attractive target for new drugs that may intervene in the development of human papillary thyroid carcinomas.
 

- Journal of Clinical Investigation
 

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/94.

 
Subscribe to Thyroid Newsletter
E-mail Address:

 

TITLE: Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

AUTHOR CONTACT: Yuri Nikiforov
University of Cincinnati, Cincinnati, Ohio, USA.
Phone: 513-558-5798; Fax: 513-558-2289; E-mail: [email protected]

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/94.

ACCOMPANYING COMMENTARY:

TITLE: A new mechanism of BRAF activation in human thyroid papillary carcinomas

AUTHOR CONTACT: Alfredo Fusco
Università degli Studi di Napoli "Federico II", Naples, Italy.
Phone: 0039-0813722857; Fax: 0039-0817463749; E-mail: [email protected]

A PDF of this article this article is available at: http://www.jci.org/cgi/content/full/115/1/20.


Related Thyroid News

Study demonstrates link between thyroid cancer and the Chornobyl accident
Recombinant TSH therapy promises better quality of life for thyroid cancer patients
A novel molecular diagnostic tool to assess risk for patients with papillary thyroid cancer
Gene Activity can Differentiate Follicular Adenoma from Follicular Thyroid Cancer
Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us