||Last Updated: Nov 17th, 2006 - 22:35:04
Are influenza vaccines worth the effort?
Each year enormous effort goes into producing influenza vaccines and delivering them to appropriate sections of the population. But a review of the evidence in this week's BMJ suggests that they may not be as effective as we think.
Oct 27, 2006, 16:57
Oseltamivir significantly reduces the risk of death from influenza
Tamiflu (oseltamivir), is effective in reducing the risk of death associated with seasonal influenza in severely ill patients,1 according to new data presented today. Treatment of infected adults was associated with a 71 per cent reduction in mortality.1 These results demonstrate the importance of the role of antivirals in the management of seasonal influenza and highlights the seriousness and risk of mortality associated with it.
Oct 2, 2006, 01:35
Prisons Unprepared for Flu Pandemic
As the fear of an impending avian flu pandemic is compelling hospitals, businesses and cities to develop preparedness plans, one of the most potentially dangerous breeding grounds of disease is woefully ill-prepared for a crisis, according to a new study being presented today by researchers at Saint Louis University.
Sep 15, 2006, 17:30
University of Pittsburgh receives $1.3 million grant for developing a promising avian flu vaccine
The National Institute of Allergy and Infectious Diseases (NIAID), of the National Institutes of Health in Bethesda, Md., has awarded a $1.3 million, two-year grant to the University of Pittsburgh School of Medicine to produce a promising avian flu vaccine that could be used in Phase I and Phase II human clinical trials
Aug 29, 2006, 03:17
Novel DNA-Based H5N1(Avian) influenza vaccine
PowderMed Ltd today announced that it has submitted regulatory documentation to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) for permission to conduct a clinical trial to test their proprietary H5N1 or avian influenza (bird flu) vaccine. It is planned that the trial will be conducted at a clinical research unit in London.
Jul 10, 2006, 19:26
Genetic differences between potential pandemic influenza strains outlined
An analysis of H5N1 influenza samples in Southeast Asia shows not only how the two strains that have caused human disease are related but also that they belong to two different, distinct genetic subgroups. Researchers from the Centers for Disease Control and Prevention report their findings today at the International Conference on Emerging Infectious Diseases.
Mar 21, 2006, 02:26
Avian flu virus needs only minor adaptations to infect humans
The H5N1 avian influenza virus, commonly known as "bird flu," is a highly contagious and deadly disease in poultry. So far, its spread to humans has been limited, with 177 documented severe infections, and nearly 100 deaths in Indonesia, Vietnam, Thailand, Cambodia, China, Iraq, and Turkey as of March 14, 2006, according to the World Health Organization (www.who.int).
Mar 18, 2006, 02:02
Influenza-Associated Hospitalization in a Subtropical City
Influenza is estimated to be responsible for a million deaths worldwide every year. In developed countries, epidemics of influenza have long been known to increase hospital admissions and mortality. This impact has been measured quantitatively in many studies dating back over a century. The statistical methods used in such research have involved both “comparative” and, more recently, “regressive” techniques.
Mar 8, 2006, 05:02
SRL Ranbaxy offers a quicker bird flu diagnostic test
SRL Ranbaxy, a pathology laboratory network promoted by India's pharma major Ranbaxy Laboratories, Monday announced the launch of the first diagnostic test for bird flu that can give results in just a day.
Feb 14, 2006, 19:55
Bird flu vaccine may be fruitless
A vaccine the British government ordered as a defence against avian flu may not be effective, latest scientific findings suggest.
Feb 14, 2006, 19:37
Reactome - Starry Sky Web model of Influenza-Host Lifecycles
A "starry sky" map linking the myriad interactions between the influenza virus and its human host will help guide researchers in creating new anti-viral drugs, say researchers at UT Southwestern Medical Center.
Jan 31, 2006, 19:35
Experimental Bird Flu Vaccine Provides 100 Percent Protection
University of Pittsburgh researchers announced they have genetically engineered an avian flu vaccine from the critical components of the deadly H5N1 virus that completely protected mice and chickens from infection. Avian flu has devastated bird populations in Southeast Asia and Europe and so far has killed more than 80 people.
Jan 28, 2006, 13:04
Getting ready for the 'Bird flu'
In 1918, nearly 40 million people died in a flu pandemic. Three such pandemics have occurred during the last 100 years.
Jan 17, 2006, 18:40
Avian influenza virus shows systemic spread
Researchers at Erasmus Medical Center have demonstrated systemic spread of avian influenza virus in cats infected by respiratory, digestive, and cat-to-cat contact. The paper by Rimmelzwaan et al., "Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts," appears in the January issue of The American Journal of Pathology and is accompanied by a commentary.
Jan 14, 2006, 18:52
FDA Affirms Safety of Tamiflu
The Pediatric Advisory Committee of the U.S. Food and Drug Administration (FDA) has confirmed the safety of Tamiflu (oseltamivir phosphate) in children following a scheduled comprehensive review of data about the use of Tamiflu in children. According to Dr. Robert M. Nelson, chairman of the committee, there is “no concern at all” that Tamiflu played a role in the reported deaths of children with influenza in Japan. Dr. Nelson is an associate professor in the department of anesthesia and critical care at The Children’s Hospital of Philadelphia.
Nov 19, 2005, 23:55
Wild birds help to create human flu vaccine
Samples collected by WCS in international collaboration effort in Mongolia to be used in development of human pandemic influenza vaccine.
Nov 6, 2005, 14:36
COLD-fX® cuts recurrent colds by more than half
The results of a new study to be published in the Canadian Medical Association Journal show that COLD-fX®, an anti-flu, anti-cold pill, reduced the incidence and frequency of recurrent colds by more than half. It also cut the duration of colds and significantly reduced their severity.
Oct 25, 2005, 05:01
CDC Declared Spanish Flu Virus a Select Agent
The Centers for Disease Control and Prevention (CDC) published on 20 October, 2005 in the Federal Register an interim rule declaring the strain of influenza responsible for the 1918 pandemic as a select agent. There are currently 41 other agents and toxins listed as select agents under the Public Health Security and Bioterrorism Preparedness and Response Act of 2002.
Oct 23, 2005, 18:14
Genomic Data to Help Understand Evolution of Flu Viruses
In the first large-scale effort of its kind, researchers have determined the full genetic sequence of more than 200 distinct strains of human influenza virus. The information, being made available in a publicly accessible database, is expected to help scientists better understand how flu viruses evolve, spread and cause disease. The genomic data already has enabled scientists to determine why the 2003-4 annual influenza vaccine did not fully protect individuals against the flu that season.
Oct 6, 2005, 23:32
What was the Spanish Flu Pandemic?
The Spanish Flu Pandemic, also known as the Great Influenza Pandemic, the 1918 Flu Epidemic, and La Grippe, was an unusually severe and deadly strain of influenza, a viral infectious disease, that killed some 25 million to 50 million people worldwide in 1918 and 1919. It is thought to have been one of the most deadly pandemics so far in human history.
Oct 6, 2005, 23:23
Unmasking the 1918 Influenza Virus
The mysteries of the 1918-1919 influenza pandemic, that killed an estimated 50 million people across the globe, are finally beginning to be solved. Two scientific papers published this week provide insights into the virus that caused the most deadly influenza outbreak in modern history. This virus was unusual because it spread so quickly, was so deadly, and exacted its worst toll among the young and healthy. In just over one year, the virus infected one-third of the world’s population with death rates approximately 50 times higher than those associated with regular seasonal influenza.
Oct 6, 2005, 23:13
Why Spanish flu was so lethal
The 1918 Spanish flu was a global disaster, killing an estimated 20 to 50 million people, many of them otherwise healthy adults. By partially reconstructing the Spanish flu virus, researchers have now discovered at least part of what made the virus so lethal, thus providing essential information for influenza drug and vaccine research.
Oct 6, 2005, 23:03
Researchers Reconstruct 1918 Pandemic Influenza Virus
Influenza pandemics occur when a new strain emerges to which people have little or no immunity. Most experts believe another pandemic will occur, but it is impossible to predict which strain will emerge as the next pandemic strain, when it will occur or how severe it will be.
Oct 6, 2005, 21:26
FDA Approves New Influenza Vaccine Fluarix for Upcoming Flu Season
The Food and Drug Administration (FDA) today approved Fluarix, an influenza vaccine for adults that contains inactivated virus. Fluarix is approved to immunize adults 18 years of age and older against influenza virus types A and B contained in the vaccine. Influenza is also commonly called the flu.
Sep 1, 2005, 01:27
One Vaccine May Protect Against Both Parainfluenza and Influenza Viruses
Researchers from Wisconsin and Japan have developed a live vaccine that may protect against both the influenza and human parainfluenza viruses. They report their findings in the June 2005 issue of the Journal of Virology.
Jun 20, 2005, 16:08
Low Dose Oral Interferon Alfa-n3 May Serve as a Potential Therapy for Avian Flu
The anticipated clinical trials in human volunteers (to be conducted in both the U.S. and Asia) are designed to determine whether Low Dose Oral Interferon Alfa-n3, delivered in a new, experimental oral drug delivery format, can resuscitate the broad-spectrum antiviral genes, which are shut down by dreaded viruses such as avian flu and smallpox.
Mar 24, 2005, 09:33
Trial of Experimental Avian Flu Vaccine
Fast-track recruitment has begun for a trial to investigate the safety of a vaccine against H5N1 avian influenza, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced today.
Mar 24, 2005, 05:24
Inactivated New Human Influenza Vaccine Progressing Through the Pre-Clinical Stage
Current epidemiology shows that H5N1 is highly infectious and pathogenic for birds, but not that serious for humans. However, whenever H5N1 virus combines with human flu virus and both of them recombine to become a new flu virus, then it is possible for that virus to be highly infectious and pathogenic to humans.This kind of pandemic caused by the recombination of human-animal flu virus has historically happened three times. It caused worldwide disaster each time.
Mar 3, 2005, 16:41
Immune cooperation foils influenza A virus infection
Influenza A virus (fluA) is a major human pathogen. The role of certain white bloods cells, known as natural killer (NK) cells, in the innate immune response to fluA is not well understood. In the December 15 issue of the Journal of Clinical Investigation, Xiao-Song He and colleagues from the VA Medical Center in Palo Alto demonstrate that upon exposure of adult cells to fluA, NK cells produce IFN-gamma, which stimulates the immune system to destroy foreign material.
Dec 16, 2004, 17:43
Implicating results of H5N1 avian influenza virus laboratory study in ducks
- Highly pathogenic H5N1 virus replicates in the respiratory and intestinal tracts of experimentally infected domestic ducks and contact ducks. Large amounts of virus (103.5 – 10 5.5 per ml) are excreted via the respiratory route as well as in faeces.
Nov 4, 2004, 08:35