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Last Updated: Sep 13, 2008 - 5:00:44 PM |
Latest Research
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Genetics
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Genetic Disorders
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Huntington's
Link between Huntington's and abnormal cholesterol levels in brain discovered
Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington's disease affects the brain. The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington's protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.
Dec 3, 2006 - 3:10:30 PM
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Latest Research
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Genetics
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Genetic Disorders
:
Huntington's
PARP1 inhibitors can protect Huntington's disease affected cells from damage
An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels. In the August issue of Chemistry & Biology, a research team from the MassGeneral Institute for Neurodegenerative Disease (MIND) describes their discovery of a novel inhibitor of Poly (ADP-ribose) polymerase (PARP1) and their findings that PARP1 inhibitors can protect HD-affected cells from damage in laboratory assays.
Jul 30, 2006 - 2:41:00 AM
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Latest Research
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Genetics
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Genetic Disorders
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Huntington's
Gene therapy protects neurons in Huntington's disease
Researchers at Rush University Medical Center, Chicago, and Ceregene Inc., San Diego, have successfully used gene therapy to preserve motor function and stop the anatomic, cellular changes that occur in the brains of mice with Huntington's disease (HD). This is the first study to demonstrate that, using this delivery method, symptom onset might be prevented in HD mice with this treatment.
Jun 30, 2006 - 3:02:00 AM
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Latest Research
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Genetics
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Genetic Disorders
:
Huntington's
Huntingtin cleavage is caused by caspase-6
Researchers at the University of British Columbia's Centre for Molecular Medicine and Therapeutics (CMMT) have provided ground-breaking evidence for a cure for Huntington disease in a mouse offering hope that this disease can be relieved in humans.
Jun 17, 2006 - 8:10:00 PM
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Latest Research
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Genetics
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Genetic Disorders
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Huntington's
Clioquinol, an antibiotic shows new promise for Huntington's Disease
Clioquinol, an antibiotic that was banned for internal use in the United States in 1971 but is still used in topical applications, appears to block the genetic action of Huntington's disease in mice and in cell culture, according to a study reported by San Francisco VA Medical Center (SFVAMC) researchers.
Sep 12, 2005 - 6:14:00 PM
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Latest Research
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Genetics
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Genetic Disorders
:
Huntington's
Potential therapeutic target for Huntington's disease
Researchers studying yeast cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment.
Apr 7, 2005 - 6:14:00 PM
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