RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
  Drug Delivery
  Nanotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Biotechnology Channel

subscribe to Biotechnology newsletter
Latest Research : Biotechnology

   EMAIL   |   PRINT
Triterpenoids Protect Against Oxidative and Electrophile Stress

Mar 30, 2005 - 6:45:00 AM
Cells that lacked Nrf2, the principal phase 2 transcription factor, and/or Keap1, the sensor for inducers and a repressor of Nrf2, displayed diminished ability to respond to the TP analogs.

 
[RxPG] Albena Dinkova-Kostova et al. report that synthetic triterpenoid (TP) analogs of oleanolic acid can activate the phase 2 response, which protects cells against electrophile and oxidant toxicities and blocks the inflammatory response to IFN-γ.

The specific mechanisms of the antiinflammatory and anticarcinogenic effects of these TPs remain unknown. To investigate these mechanisms, the authors exposed varying mouse and human cells to these TP analogs and detected an increase in the activity of NQO1, a chemoprotective enzyme, and a decrease in the synthesis of IFN-γ-evoked, proinflammatory iNOS and COX-2 enzymes.

Potencies of TP analogs for both responses closely correlated over a wide range of concentrations. The most effective analogs had activated Michael acceptor groups in rings A and C, at a critical distance from each other. In addition, TP-225, the most potent TP, protected human retinal epithelial cells against photooxidative damage by UV-A light.

Cells that lacked Nrf2, the principal phase 2 transcription factor, and/or Keap1, the sensor for inducers and a repressor of Nrf2, displayed diminished ability to respond to the TP analogs.



Publication: "Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress" by Albena T. Dinkova-Kostova, Karen T. Liby, Katherine K. Stephenson, W. David Holtzclaw, Xiangqun Gao, Nanjoo Suh, Charlotte Williams, Renee Risingsong, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, and Paul Talalay
On the web: Read the full text of this article 

Advertise in this space for $10 per month. Contact us today.


Related Biotechnology News
Synthetic protein to help regenerate new tissues
Nanostructures lend cutting edge to antibiotics
Nanoparticles could offer relief from rashes
Carbon nanotubes can affect lung lining
Chicken egg whites - answer to three-dimensional cell culture systems
Nanoparticles hitchhike on red blood cells for drug delivery
Gold Nanoparticle Molecular Ruler to Measure Smallest of Life’s Phenomena
Tiny inhaled particles take easy route from nose to brain
DNA Amplification and Detection Made Simple
Solitons Could Power Artificial Muscles

Subscribe to Biotechnology Newsletter

Enter your email address:


 Additional information about the news article
Proceedings of the National Academy of Sciences of the United States of America

PNAS is one of the world's most-cited multidisciplinary scientific serials. Since its establishment in 1914, it continues to publish cutting-edge research reports, commentaries, reviews, perspectives, colloquium papers, and actions of the Academy. Coverage in PNAS spans the biological, physical, and social sciences. PNAS is published weekly in print, and daily online in PNAS Early Edition. The PNAS impact factor is 10.3 for 2003. PNAS is available by subscription.

PNAS is abstracted and/or indexed in: Index Medicus, PubMed Central, Current Contents, Medline, SPIN, JSTOR, ISI Web of Science, and BIOSIS.

Please note that the articles in PNAS report original research by independent authors and do not necessarily represent the views of the National Academy of Sciences or the National Research Council.
 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)