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Latest Research : Gastroenterology
  Last Updated: Aug 27, 2011 - 8:03:46 PM

Latest Research : Gastroenterology
Weight loss by targeting satiety hormone
The uroguanylin-GUCY2C endocrine axis may provide a therapeutic target to control appetite, obesity, and metabolic syndrome, according to a study by a team of researchers, led by Scott Waldman, at Thomas Jefferson University, Philadelphia.
Aug 27, 2011 - 7:40:40 PM

Latest Research
Mayo Clinic studies how much practice makes perfect when performing colonoscopies
ROCHESTER, Minn. - A colonoscopy is an invaluable procedure for detecting problems in the colon and rectum. Doctors can often diagnose gastrointestinal issues and even catch the warning signs of colorectal cancer. Perfecting the skills required for this delicate procedure takes practice. But just how much practice makes perfect?
May 9, 2011 - 4:00:00 AM

Latest Research
Attacking bowel cancer on 2 fronts
Stem cells in the intestine, which when they mutate can lead to bowel cancers, might also be grown into transplant tissues to combat the effects of those same cancers, the UK National Stem Cell Network (UKNSCN) annual science meeting will hear today.
Mar 30, 2011 - 4:00:00 AM

Latest Research
New gene sites affecting nonalcoholic fatty liver disease discovered
NAFLD is a condition where fat accumulates in the liver (steatosis) and can lead to liver inflammation (nonalcoholic steatohepatitis or NASH) and permanent liver damage (fibrosis/cirrhosis). NAFLD affects anywhere from 11% to 45% of some populations and is associated with obesity, hypertension, and problems regulating serum lipids or glucose.
Mar 10, 2011 - 5:00:00 AM

Latest Research
New vaccine technology protects mice from hepatitis C virus
Immunology: Three percent of the world's population is currently infected by hepatitis C. The virus hides in the liver and can cause cirrhosis and liver cancer, and it's the most frequent cause of liver transplants in Denmark. Since the virus mutates strongly, we have no traditional vaccine, but researchers at the University of Copenhagen are now the first to succeed in developing a vaccine, which provides future hope for medical protection from this type of hepatitis.
Feb 23, 2011 - 5:00:00 AM

Latest Research
Y-90 radioembolization offers promise for late-stage liver cancer
INDIANAPOLIS -- The latest weapon against inoperable liver cancer is so tiny that it takes millions of them per treatment, but according to interventional radiologists at the Indiana University School of Medicine, those microscopic spheres really pack a therapeutic punch.
Dec 14, 2010 - 5:00:00 AM

Latest Research
Gastric bypass alters sweet taste function
Gastric bypass surgery decreases the preference for sweet-tasting substances in obese rats, a study finding that could help in developing safer treatments for the morbidly obese, according to Penn State College of Medicine researchers.
Nov 2, 2010 - 4:00:00 AM

Latest Research
Liver hormone is a cause of insulin resistance
Researchers have identified a hormone produced and secreted by the liver as a previously unknown cause of insulin resistance. The findings, in the November issue of Cell Metabolism, a Cell Press publication, suggest a new target for the treatment of insulin resistance and type 2 diabetes, the researchers say.
Nov 2, 2010 - 4:00:00 AM

Latest Research : Surgery : Transplantation
Increased mortality risk in later years in obese children following Liver transplantation
A new study from the University of Washington reported obese children are at increased mortality risk in later years following primary liver transplantation (LT).
Oct 28, 2010 - 6:27:35 PM

Latest Research
NC Children's Hospital part of $12 million grant to create first-of-kind registry for IBD
CHAPEL HILL, N.C. -- Building on the success of previous efforts among researchers and caregivers to improve the care of chronically ill children, North Carolina Children's Hospital is one of 27 sites across the nation developing a disease registry for inflammatory bowel diseases (IBD). The research collaborative is part of a $12-million grant to Cincinnati Children's Hospital Medical Center, enabling the creation of this first-of-its-kind registry system providing real time information on thousands of IBD cases across the country and, eventually, around the world.
Oct 13, 2010 - 4:00:00 AM

Latest Research
NYU Langone Medical Center receives NIH Director's Transformative Research Projects award
The National Institutes of Health (NIH) announced today that Martin J. Blaser, MD, the Frederick H. King Professor of Internal Medicine at NYU Langone Medical Center has been awarded one of only twenty NIH Director's Transformative Research Projects (T-R01) award for research entitled Disappearing Gastrointestinal Microbiota in Epidemic Obesity. The project will examine whether changes in the human microbiome as a result of antibiotic use early in life has fueled the epidemic of obesity. The amount of the award is approximately $6.6 million over a five year period.
Sep 30, 2010 - 4:00:00 AM

Latest Research
Unique gastroenterology procedure developed in adults shows promise in pediatrics
The use of device-assisted enteroscopy, a technique that allows complete examination of the small bowel, may be just as successful pediatrics as it has been in adult medicine, according to a study from Nationwide Children's Hospital.
Sep 27, 2010 - 4:00:00 AM

Latest Research
Proof that a gut-wrenching complaint -- irritable bowel syndrome -- is not in your head
Irritable bowel syndrome makes life miserable for those affected -- an estimated ten percent or more of the population. And what irritates many of them even more is that they often are labeled as hypochondriacs, since physical causes for irritable bowel syndrome have never been identified. Now, biologists at the Technische Universitaet Muenchen (TUM) have shed new light on the matter: They have discovered mini-inflammations in the mucosa of the gut, which upset the sensitive balance of the bowel and are accompanied by sensitization of the enteric nervous system.
Aug 19, 2010 - 4:00:00 AM

Latest Research
Some patients with hepatitis B faring better after liver transplant
ROCHESTER, Minn. -- Treatment to reduce recurrence of hepatitis B appears to improve liver transplant outcomes for some patients, according to a Mayo Clinic study presented at the American Transplant Congress under way May 1-5 in San Diego.
May 4, 2010 - 4:00:00 AM

Latest Research
Study shows liver transplant center impacts patient outcomes
ROCHESTER, Minn. -- For patients in need of a liver transplant, their choice of a transplant center can make a noteworthy difference in their outcomes, according to a Mayo Clinic study presented at the American Transplant Congress under way May 1-5 in San Diego.
May 2, 2010 - 4:00:00 AM

Latest Research : Gastroenterology : Liver
Extracorporeal liver support therapy shows promise for severely ill patients
Results from two studies presented on 16th April 2010 at the International Liver Congress 2010 have shown that treatment with extracorporeal devices may not confer a survival advantage for severe liver failure patients, despite positive dialysis effects. However, results among a small sub-group of patients show promise.
Apr 18, 2010 - 12:49:40 PM

Latest Research
Keeping the weight off after a very low-energy diet
Simple advice can reduce the risk of weight regain after a very-low-energy diet: the secret to keeping the weight off is to switch back to normal food gradually, reveals a dissertation from the Sahlgrenska Academy, at the University of Gothenburg, Sweden, which also contains new research results for patients who have undergone obesity surgery.
Apr 4, 2010 - 4:00:00 AM

Latest Research : Gastroenterology : Inflammatory Bowel Disease
Demographic profile suggests environmental role in etiology of Crohn's Disease
A research team from the United Kingdom determined the hospitalized prevalence of severe IBD and subsequent 5-year mortality in Wales, and investigated associations between severe IBD and social deprivation, distance travelled to hospital, and other socio-demographic characteristics.

Feb 6, 2010 - 12:58:48 PM

Latest Research
A novel and simple formula to predict treatment success in chronic hepatitis C
The likelihood of treatment success of 48 wk peg-interferon (PEG-IFN) plus ribavirin (RBV) therapy for chronic hepatitis C may be predicted by viral kinetics on therapy. In particular, recent studies have shown that sustained virological response (SVR) can be predicted by a rapid virological response (RVR), and an early virological response (EVR). Nevertheless, the current dosing regimens could potentially under-treat some patients and additional measurements of viral response is needed to facilitate individualization of therapy. Among predictive factors already reported, many are not readily available from daily clinical assessment, because they require genomic analyses and/or advanced experimental methods. The prediction with simply available data may be useful.
Jan 14, 2010 - 5:00:00 AM

Latest Research
Fat in the liver -- not the belly -- is a better marker for disease risk
New findings from nutrition researchers at Washington University School of Medicine in St. Louis suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver.
Aug 24, 2009 - 4:00:00 AM

Latest Research
Sequential TACE and cryosurgery can improve survival times for patients with HCC?
Hepatocellular carcinoma (HCC)--a liver cancer--is recognized as one of the most common cancers in the world that disproportionately affects Southeast Asians and Africans. While there are therapies that possibly provide a cure, surgical removal and liver transplantation are invasive and radical options. However, even these approaches only benefit a small proportion of the total number HCC patients. Cryosurgery is a minimally invasive technique of using extreme low temperatures to freeze and kill tumors, improve patient' survival times, and reduce surgical complications. Cryosurgery can be potentially applied to any surgery for solid organ cancers where conventional surgery would otherwise be used to remove undesirable tissue. It is anticipated that in the near future, cryosurgery will increasingly replace the use of traditional techniques of ablation.
Aug 11, 2009 - 4:00:00 AM

Latest Research
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively referred to as IBD.
Jun 2, 2009 - 4:00:00 AM

Latest Research
No longer afraid to be a bridesmaid or travel with the boss
CHICAGO --- One of Laurie Keefer's patients was afraid to be a bridesmaid in a friend's wedding, others worried about traveling with the boss or even going to parties in peoples' homes.
May 13, 2009 - 4:00:00 AM

Latest Research
UIC researchers measure health effects of Chicago's waterways
Researchers at the University of Illinois at Chicago School of Public Health are conducting a study to determine the health effects associated with recreational activities such as boating, canoeing, kayaking and fishing on Chicago's waterways.
Mar 23, 2009 - 4:00:00 AM

Latest Research
Putting a name to the fluke
In a world first, a UQ researcher has developed a non-invasive screening method for potentially fatal liver and intestinal flukes plaguing the lives of an estimated 9 million people throughout southeast Asia.
Feb 11, 2009 - 5:00:00 AM

Latest Research : Gastroenterology
14.6% of patients with Iron deficiency anaemia of obscure origin have gluten sensitive enteropathy (GSE
A research team led by Prof. Reza Malekzadeh studied the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. Their findings will be published on December 28, 2008 in the World Journal of Gastroenterology.
Dec 31, 2008 - 8:13:26 AM

Latest Research
Novel IBS treatment developed at UB garners $8.5 million for seven-year clinical trial
BUFFALO, N.Y. -- Irritable bowel syndrome is a chronic, debilitating disorder affecting 25 million people in the U.S -- 14-24 percent of women and 5-19 percent of men.
Nov 13, 2008 - 5:00:00 AM

Latest Research : Gastroenterology : Liver : Hepatitis
Factors for developing IPF in Hepatitis C patients
There is little or no information on the yearly cumulative incidence and risk factors on the development rate of Idiopathic pulmonary fibrosis in patients with HCV.A research team led by Yasuji Arase from Toranomon Hospital of Japan addresses this, and the study will be published on October 14, 2008 in the World Journal of Gastroenterology.
Oct 23, 2008 - 2:12:44 PM

Latest Research
Children's Hospital of Pittsburgh of UPMC scientific director elected to Institute of Medicine
David H. Perlmutter, MD, scientific director and physician-in-chief at Children's Hospital of Pittsburgh of UPMC, has been elected to the prestigious Institute of Medicine (IOM).
Oct 13, 2008 - 4:00:00 AM

Latest Research : Gastroenterology
Endoscopy not needed in asymptomatic children after caustic ingestion
A new study from researchers in Italy reports that endoscopy may not be necessary in children who show no symptoms after a caustic ingestion. The results demonstrated that the incidence of severe abnormalities of the esophagus in children without any early symptoms is very low and an endoscopy could be avoided.
Sep 26, 2008 - 11:52:29 PM

Latest Research
How to prevent liver damage induced by anti-tuberculosis treatment?
About one third of the world's population has latent tuberculosis and roughly 9 million cases of active tuberculosis emerge annually resulting in 2-3million deaths. Most new cases occur in the most populated nations like India and China. Combination chemotherapy containing Isoniazid (INH), Rifampicin (RMP), Pyrazinamide (PZA) with or without ethambutol for initial 2 months followed by a continuation phase of 4-6 months of Isoniazid and Rifampicin is the preferred regimen for successful treatment and for preventing acquired resistance. Drug induced hepatotoxicity is a potentially serious adverse effect of antituberculosis (ATT) regimen. A higher risk of hepatotoxicity has been reported in Indian patients (up to 11.5%) than in their western counterpart (up to 4.3%). The only measure available for managing hepatotoxicity is stopping the offending agents, once there is an evidence of liver damage and reintroducing the same after normalization of liver enzymes. Preventive therapy of contacts causes severe hepatotoxicity more often than curative treatment of clinical tuberculosis. Search for non-toxic and highly effective new compounds for treating tuberculosis or an effective vaccine conferring sustained protective immunity have yet not seen the face of success.
Sep 19, 2008 - 4:00:00 AM

Latest Research
String probes for devastating childhood digestive disease
A swallowed string may someday replace the invasive, uncomfortable endoscope now used to diagnose a devastating childhood disease of the esophagus.

Jul 30, 2008 - 4:00:00 AM

Latest Research : Gastroenterology
Integrins act as receptors to Rotavirus
Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhoea. In a report online in the Proceedings of the National Academy of Sciences, Estes and her colleagues describe two receptors for the enterotoxin, both of them integrins.

Jun 30, 2008 - 9:07:43 AM

Latest Research
NCI grant launches clinical trials for colon cancer screening
EVANSTON, Ill. --- A Northwestern University biomedical engineer who has developed optical technology shown to be effective for the early detection of colon cancer has received a $7.5 million grant over five years from the National Cancer Institute to further study an instrument that potentially could become a routine colon cancer screening test and to launch large-scale clinical trials.
Jun 25, 2008 - 4:00:00 AM

Latest Research
'Addicted' cells provide early cancer diagnosis
Scientists at the Institute of Food Research have detected subtle changes that may make the bowel more vulnerable to the development of tumours.
Jun 10, 2008 - 4:00:00 AM

Latest Research
Weizmann Institute scientists develop a new approach to treating autoimmune disease
In autoimmune diseases, the immune system turns against the body's own tissues and organs, wreaking havoc and destruction for no apparent reason. Partly because the origins of these diseases are so obscure, no effective treatment exists, and the suffering they inflict is enormous. Now Weizmann Institute scientists have developed a method that in the future may make it possible to treat autoimmune diseases effectively without necessarily knowing their exact cause. Their approach is equivalent to sending a police force to suppress a riot without seeking out the individuals who instigated the unrest.
Jun 2, 2008 - 4:00:00 AM

Latest Research
A better method is found for the treatment of patients with portal hypertension
Bleeding from ruptured esophageal varices is the main complication of portal hypertension and a major cause of death. About one-third of variceal bleeding episodes are fatal while 70% of survivors re-bleed within a year. Propranolol, the drug of choice for primary prevention of variceal bleeding, has been found to be effective in 45% of patients who have never bled, and in only 40% of patients who have had a bleeding episode before. Thus, this drug does not protect a significant number of patients and combination therapy has been advocated as a result. Various drug combinations have been tried, most commonly propranolol with isosorbide mononitrate. However, the problem with combination therapy is an increased incidence of side effects, poor tolerability and lack of compliance. The search for an ideal drug combination that is effective, relatively free from side effects and easy to administer, has been elusive.
May 20, 2008 - 4:00:00 AM

Latest Research
Synergistic growth inhibitory effect of herbal extracts against HCC and lung cancer cells
Several herbs with diversified pharmacological properties are known to be rich sources of chemical constituents that may have potential for the treatment of several human cancers. Data from the Department of Preclinical Science, Faculty of Medicine, Thammasat University, demonstrates that the growth inhibitory activity of doxorubicin or cisplatin, as single agents, may be modified in combination with emblic myrobalan or belleric myrobalan extracts and may be synergistically enhanced in some cases.
Apr 30, 2008 - 4:00:00 AM

Healthcare : India Healthcare
India unveils zinc tablet to control diarrhoea
New Delhi, April 7 - India Monday unveiled a zinc dispersible tablet to control diarrhoea, a disease that kills nearly 500,000 children in the country every year.

Apr 7, 2008 - 7:55:20 PM

Latest Research
What change does prokineticin 2/Bv8 have in human hepatocellular carcinoma?
Liver hepatocarcinoma is a highly vascularized cancer, and more and more research is focused on the molecules controlling angiogenesis. In 2001, two novel peptides, known as prokineticin 1/EG-VEGF (PK1/EG-VEGF) and prokineticin 2/Bv8 (PK2/Bv8), were identified, as having potent angiogenic activities. The angiogenic potential of these two peptides during human hepatocellular carcinoma progression was evaluated. These findings show, that only, PK2/Bv8 is expressed in liver and -- surprisingly -- that its expression decreases during hepatocellular carcinoma. Furthermore, these results show that PK2/Bv8 expression is restricted specifically to liver resident macrophages, thus suggesting a role in Kuppfer cell physiology.
Mar 18, 2008 - 4:00:00 AM

Latest Research
Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Heavier alcohol consumption increases the risk of ESCC. There are synergetic interactions among alcohol drinking and ALDH2, ADH1B, CYP2E1 genotypes. The risk of ESCC in moderate-to-heavy drinkers, ALDH2 (1/2) combined with the ADH1B (1/1) genotype; ALDH2 (1/2) combined with the CYP2E1 (c1/c1) genotype; leads to synergetic interactions, higher than drinkers with ALDH2 (1/1) + ADH1B (1/2 + 2/2); ALDH2 (1/1) + CYP2E1 (c1/c2 + c2/c2).
Mar 13, 2008 - 4:00:00 AM

Latest Research
Scientists successfully treat new mouse model of inflammatory bowel disease
March 6, 2008 -- Researchers trying to improve cancer immune therapy have made an unexpected find: They've produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that afflict approximately 1.4 million Americans with abdominal pain, constipation and diarrhea.
Mar 6, 2008 - 5:00:00 AM

Latest Research
Type 2 diabetes may be caused by intestinal dysfunction
NEW YORK (March 5, 2008) -- Growing evidence shows that surgery may effectively cure Type 2 diabetes -- an approach that not only may change the way the disease is treated, but that introduces a new way of thinking about diabetes.
Mar 5, 2008 - 5:00:00 AM

Latest Research : Gastroenterology : Inflammatory Bowel Disease : Crohn's Disease
Crohn's disease or gastrointestinal endometriosis?
Crohn's disease may mimic gastrointestinal endometriosis in its clinical presentation.A case report published on January 7, 2008 in the World Journal of Gastroenterology describes such a patient.


Feb 22, 2008 - 8:03:09 AM

Latest Research : Gastroenterology : Liver
small intestinal bacteria overgrowthplays a role in nonalcoholic fatty liver disease?
An article recently published in the January 14 issue of the World Journal of Gastroenterology has great significance for NASH. This article will undoubtedly bring about new pathogenesis and treatment of NASH.
Feb 22, 2008 - 7:09:07 AM

Latest Research : Gastroenterology : Inflammatory Bowel Disease : Crohn's Disease
Alternative strategy better for Crohn's Disease
An international research study, published in The Lancet, has thrown into question the current method of treating Crohn’s disease – opening the door to a safer and more effective treatment option for sufferers of the chronic disease.
Feb 22, 2008 - 6:52:59 AM

Latest Research
May inflammatory bowel disease mimic gynecological disorders in its clinical presentation
Endometriosis is a condition of unknown etiology in which endometrial tissue occurs at extra-uterine sites, including ovaries, fallopian tubes, and gastrointestinal tract. It usually occurs between 30 and 40 years of age. Four to 17% of menstruating women develop endometriosis. When the disease involves the small bowel, it usually has a benign course, but in rare circumstances, it may present as abdominal emergency. Invasive bowel endometriosis can present as bowel obstruction. The major cause of obstruction is stricture formation and adhesions, which occasionally mimic Crohn's disease or a malignancy in its clinical presentation.
Feb 22, 2008 - 5:00:00 AM

Latest Research
Do patients with inflammatory bowel disease receive optimal care?
Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal disease. The disease has a relatively higher morbidity in young adults, in whom growth, education, employment and wellbeing all are adversely influenced. A number of guidelines for management of inflammatory bowel disease are available for bringing evidence-based medicine into full play to improve IBD patient care. What about the actual quality of care for patients with IBD in China?
Feb 22, 2008 - 5:00:00 AM

Latest Research
University of Sydney researchers find new evidence linking kava to liver damage
In recent years, serious concerns about the dangers of kava and the effects on the liver have resulted in regulatory agencies, such as the US Food and Drug Administration and Australia's Therapeutic Goods Administration, banning or restricting the sale of kava and kava products.
Feb 22, 2008 - 5:00:00 AM

Latest Research
A strange case of upper obstructive syndrome
Aorto-duodenal fistulae (ADF) are the most frequent aorto-enteric fistulae (80%) and the most frequent presenting sign of ADF is upper gastrointestinal bleeding (UGI). A 59-year-old male patient, who underwent an aortic-bi-femoral bypass five years ago, was admitted to the Emergency Room after five days of persistent occlusive syndrome with dyspepsia and biliary vomiting. Computed tomography (CT) scan showed in the third duodenal segment the presence of an area with the characteristics of inflammatory tissue, including air bubbles between the duodenum and aortic-bi-femoral prosthesis adherent to the third duodenal portion (pcomma signq) (Figure 1). Microbiological cultures and scintigraphy were unremarkable. Esophago-gastro-duodenoscopy showed the aortic prosthesis crossing the third segment of duodenal wall occluding the intestinal lumen (Figure 2). At laparotomy, after viscerolisis, the prosthesis was detached from duodenal wall and the intestine failed to close transversely (Figure 3). To protect the intestinal wall, a pediculated fragment of the greater omentum was placed between the duodenum and aortic bypass. Furthermore, a gastrojejunal Roux anastomosis was employed. The prosthesis was not changed because there were no local or systemic signs of infection. The post-operative course was uneventful.
Feb 22, 2008 - 5:00:00 AM

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