|Last Updated: Nov 2, 2013 - 11:52:55 AM
4 UCLA stem cell researchers receive CIRM Early Translational grants
Four researchers from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational Research Awards totaling approximately $13 million from the California Institute for Regenerative Medicine, the state's stem cell agency. The UCLA researchers received four of the 12 total awards; no other institution received more than one.
Sep 3, 2013 - 4:00:00 AM
Genetics defines a distinct liver disease
Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.
Apr 21, 2013 - 4:00:00 AM
Nerve damage may underlie widespread, unexplained chronic pain in children
Massachusetts General Hospital (MGH) investigators have described what may be a newly identified disease that appears to explain some cases of widespread chronic pain and other symptoms in children and young adults. Their report that will appear in the April issue of the journal Pediatrics, and has received early online release, finds that most of a group of young patients seen at the MGH for chronic, unexplained pain had test results indicating small-fiber polyneuropathy, a condition not previously reported in children. The MGH investigators call this new syndrome juvenile-onset small-fiber polyneuropathy or JOSeFINE.
Mar 11, 2013 - 4:00:00 AM
Colonoscopy cost sharing eliminated for privately insured patients
The federal government has issued an important clarification on preventive screening benefits under the Affordable Care Act. Patients with private insurance will no longer be liable for cost sharing when a pre-cancerous colon polyp is removed during screening colonoscopy. This ensures colorectal cancer screening is available to privately insured patients at no additional cost, as intended by the new healthcare law. Patients with Medicare coverage must still pay a coinsurance when a polyp is removed as a result of the screening colonoscopy.
Feb 25, 2013 - 5:00:00 AM
EASL publishes first comprehensive literature review on the burden of liver disease in Europe
Brussels and Geneva, 20th February 2013 --- Major progress has been made in the past 30 years in the knowledge and management of liver disease, yet approximately 29 million Europeans still suffer from a chronic liver condition.
Feb 21, 2013 - 5:00:00 AM
Targeting neurotransmitter may help treat gastrointestinal conditions
HERSHEY, Pa. -- Selective targeting of the neurotransmitter that differentially affects brain cells that control the two distinct functions of the pancreas may allow for new medication therapies for conditions like diabetes, dyspepsia and gastro-esophageal reflux, according to Penn State College of Medicine researchers.
Dec 4, 2012 - 5:00:00 AM
NIH launches free database of drugs associated with liver injury
A free source of evidence-based information for health care professionals and for researchers studying liver injury associated with prescription and over-the-counter drugs, herbals, and dietary supplements is now available from the National Institutes of Health. Researchers and health care professionals can use the LiverTox database to identify basic and clinical research questions to be answered and to chart optimal ways to diagnose and control drug-induced liver injury.
Oct 12, 2012 - 4:00:00 AM
Genetic clues to the causes of primary biliary cirrhosis!
Researchers have newly identified three genetic regions associated with primary biliary cirrhosis (PBC), the most common autoimmune liver disease, increasing the number of known regions associated with the disorder to 25.
Sep 9, 2012 - 4:00:00 AM
Taxman Foundation pledges $2.5 million to boost training of digestive disease experts
The Taxman Family Foundation will donate $2.5 million to support the training of specialists in the study and treatment of digestive disease at the University of Chicago Medicine.
Jul 2, 2012 - 4:00:00 AM
Early introduction of biologic therapy improves Crohn's disease outcomes
A large-scale study of medical claims data shows that introducing sophisticated biologic therapies early in the course of treatment for Crohn's disease improves response to medication and reduces the need for surgery.
Apr 17, 2012 - 4:00:00 AM
GCKR and PNLPA3 genetic variants acting in combination may confer susceptibility to fatty liver disease in obese children
A study, published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, found the genetic variant Patatin-like phospholipase domain containing protein-3 (PNPLA3) acting in conjunction with the glucokinase regulatory protein (GCKR) is associated with increased susceptibility to fatty liver disease in obese children.
Mar 23, 2012 - 8:42:13 AM
NSF grant will aid Wayne State professors' mathematical modeling of fatty liver predictors
Detroit - Predicting problems in one of the body's most complex organs soon may become easier because of work being done by Wayne State University researchers.
Jan 19, 2012 - 5:00:00 AM
The economic cost of advanced liver disease
Health care costs for hepatitis C patients with end-stage liver disease are nearly 2.5 times higher than those in the early stages, according to a Henry Ford Hospital study.
Nov 7, 2011 - 5:00:00 AM
Social media has role in delivery of healthcare but patients should proceed with caution
Washington, DC -- Social networking sites like Facebook and YouTube can be powerful platforms to deliver and receive healthcare information, especially for patients and caregivers who are increasingly going online to connect and share experiences with others with similar medical issues or concerns. However, these sites may lack patient-centered information and can also be sources of misleading information that could potentially do more harm than good, according to the results of two separate social media-related studies unveiled today at the American College of Gastroenterology's ACG) 76th Annual Scientific meeting in Washington, DC.
Oct 31, 2011 - 4:00:00 AM
Celiac patients face potential hazard as information on cosmetic ingredients difficult to find
Washington, DC -- The lack of readily available information about cosmetic ingredients may cause patients with celiac disease who use lip, facial or body products to unknowingly expose themselves to gluten -- an ingredient they need to avoid, according to the results of a new study unveiled today at the American College of Gastroenterology's (ACG) 76th Annual Scientific meeting in Washington, DC.
Oct 31, 2011 - 4:00:00 AM
Psychological traumas experienced over lifetime linked to adult irritable bowel syndrome
Washington, DC -- The psychological and emotional traumas experienced over a lifetime -- such as the death of a loved one, divorce, natural disaster, house fire or car accident, physical or mental abuse -- may contribute to adult irritable bowel syndrome (IBS), according to the results of a study unveiled today at the American College of Gastroenterology's (ACG) 76th Annual Scientific meeting in Washington, DC.
Oct 31, 2011 - 4:00:00 AM
Acid-suppressing medications may be overprescribed for infants
Frequent spitting up, irritability and unexplained crying in infants are often very distressing to parents. Physicians frequently prescribe acid-suppressing drugs for these symptoms. However, gastroesophageal reflux disease (GERD) is an uncommon cause of these symptoms in otherwise thriving infants, and in his commentary published in the Journal of Pediatrics, Dr. Eric Hassall cautions against over-diagnosis of GERD and over-prescription of acid-suppressing drugs in children under one year of age.
Oct 20, 2011 - 4:00:00 AM
Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer
Case Western Reserve University School of Medicine and the Case Comprehensive Cancer Center are proud to announce the receipt of a highly competitive $5.4 million grant to study genetic determinants of Barrett's esophagus and esophageal adenocarcinoma. This five-year award from the National Cancer Institute will support the Barrett's Esophagus Translational Research Network (BETRNet), which consists of multiple centers collaborating to develop an understanding of the basis of Barrett's esophagus and its conversion to esophageal carcinoma. Researchers will also work to determine the role genetics and environmental factors play in the development and progression of these diseases, with the ultimate goal of reducing the mortality associated with this deadly cancer.
Oct 10, 2011 - 4:00:00 AM
Liver cancer incidence lower in patients with nonalcoholic fatty liver disease than hepatitis C
Patients with non-alcoholic fatty liver disease (NAFLD) with advanced fibrosis or cirrhosis have a lower incidence of liver-related complications and hepatocellular carcinoma (HCC) than patients infected with hepatitis C virus (HCV), according to the prospective study published in the October issue of Hepatology, a journal of the American Association for the Study of Liver Diseases. Patients with both NAFLD and HCV had similar mortality rates.
Sep 27, 2011 - 4:00:00 AM
FDA grants cardiotrophin-1 Orphan Drug status for acute liver failure treatment to Digna Biotech
Digna Biotech, a Spanish biotechnological company, announces that the Food and Drug Administration (FDA) granted cardiotrophin-1 (CT-1) Orphan Drug status for use in the treatment of acute liver failure (Designation request 11-3507).
Sep 22, 2011 - 4:00:00 AM
Weight loss by targeting satiety hormone
The uroguanylin-GUCY2C endocrine axis may provide a therapeutic target to control appetite, obesity, and metabolic syndrome, according to a study by a team of researchers, led by Scott Waldman, at Thomas Jefferson University, Philadelphia.
Aug 27, 2011 - 7:40:40 PM
Mayo Clinic studies how much practice makes perfect when performing colonoscopies
ROCHESTER, Minn. - A colonoscopy is an invaluable procedure for detecting problems in the colon and rectum. Doctors can often diagnose gastrointestinal issues and even catch the warning signs of colorectal cancer. Perfecting the skills required for this delicate procedure takes practice. But just how much practice makes perfect?
May 9, 2011 - 4:00:00 AM
Attacking bowel cancer on 2 fronts
Stem cells in the intestine, which when they mutate can lead to bowel cancers, might also be grown into transplant tissues to combat the effects of those same cancers, the UK National Stem Cell Network (UKNSCN) annual science meeting will hear today.
Mar 30, 2011 - 4:00:00 AM
New gene sites affecting nonalcoholic fatty liver disease discovered
NAFLD is a condition where fat accumulates in the liver (steatosis) and can lead to liver inflammation (nonalcoholic steatohepatitis or NASH) and permanent liver damage (fibrosis/cirrhosis). NAFLD affects anywhere from 11% to 45% of some populations and is associated with obesity, hypertension, and problems regulating serum lipids or glucose.
Mar 10, 2011 - 5:00:00 AM
New vaccine technology protects mice from hepatitis C virus
Immunology: Three percent of the world's population is currently infected by hepatitis C. The virus hides in the liver and can cause cirrhosis and liver cancer, and it's the most frequent cause of liver transplants in Denmark. Since the virus mutates strongly, we have no traditional vaccine, but researchers at the University of Copenhagen are now the first to succeed in developing a vaccine, which provides future hope for medical protection from this type of hepatitis.
Feb 23, 2011 - 5:00:00 AM
Y-90 radioembolization offers promise for late-stage liver cancer
INDIANAPOLIS -- The latest weapon against inoperable liver cancer is so tiny that it takes millions of them per treatment, but according to interventional radiologists at the Indiana University School of Medicine, those microscopic spheres really pack a therapeutic punch.
Dec 14, 2010 - 5:00:00 AM
Liver hormone is a cause of insulin resistance
Researchers have identified a hormone produced and secreted by the liver as a previously unknown cause of insulin resistance. The findings, in the November issue of Cell Metabolism, a Cell Press publication, suggest a new target for the treatment of insulin resistance and type 2 diabetes, the researchers say.
Nov 2, 2010 - 4:00:00 AM
Gastric bypass alters sweet taste function
Gastric bypass surgery decreases the preference for sweet-tasting substances in obese rats, a study finding that could help in developing safer treatments for the morbidly obese, according to Penn State College of Medicine researchers.
Nov 2, 2010 - 4:00:00 AM
Increased mortality risk in later years in obese children following Liver transplantation
A new study from the University of Washington reported obese children are at increased mortality risk in later years following primary liver transplantation (LT).
Oct 28, 2010 - 6:27:35 PM
NC Children's Hospital part of $12 million grant to create first-of-kind registry for IBD
CHAPEL HILL, N.C. -- Building on the success of previous efforts among researchers and caregivers to improve the care of chronically ill children, North Carolina Children's Hospital is one of 27 sites across the nation developing a disease registry for inflammatory bowel diseases (IBD). The research collaborative is part of a $12-million grant to Cincinnati Children's Hospital Medical Center, enabling the creation of this first-of-its-kind registry system providing real time information on thousands of IBD cases across the country and, eventually, around the world.
Oct 13, 2010 - 4:00:00 AM
NYU Langone Medical Center receives NIH Director's Transformative Research Projects award
The National Institutes of Health (NIH) announced today that Martin J. Blaser, MD, the Frederick H. King Professor of Internal Medicine at NYU Langone Medical Center has been awarded one of only twenty NIH Director's Transformative Research Projects (T-R01) award for research entitled Disappearing Gastrointestinal Microbiota in Epidemic Obesity. The project will examine whether changes in the human microbiome as a result of antibiotic use early in life has fueled the epidemic of obesity. The amount of the award is approximately $6.6 million over a five year period.
Sep 30, 2010 - 4:00:00 AM
Unique gastroenterology procedure developed in adults shows promise in pediatrics
The use of device-assisted enteroscopy, a technique that allows complete examination of the small bowel, may be just as successful pediatrics as it has been in adult medicine, according to a study from Nationwide Children's Hospital.
Sep 27, 2010 - 4:00:00 AM
Proof that a gut-wrenching complaint -- irritable bowel syndrome -- is not in your head
Irritable bowel syndrome makes life miserable for those affected -- an estimated ten percent or more of the population. And what irritates many of them even more is that they often are labeled as hypochondriacs, since physical causes for irritable bowel syndrome have never been identified. Now, biologists at the Technische Universitaet Muenchen (TUM) have shed new light on the matter: They have discovered mini-inflammations in the mucosa of the gut, which upset the sensitive balance of the bowel and are accompanied by sensitization of the enteric nervous system.
Aug 19, 2010 - 4:00:00 AM
Some patients with hepatitis B faring better after liver transplant
ROCHESTER, Minn. -- Treatment to reduce recurrence of hepatitis B appears to improve liver transplant outcomes for some patients, according to a Mayo Clinic study presented at the American Transplant Congress under way May 1-5 in San Diego.
May 4, 2010 - 4:00:00 AM
Study shows liver transplant center impacts patient outcomes
ROCHESTER, Minn. -- For patients in need of a liver transplant, their choice of a transplant center can make a noteworthy difference in their outcomes, according to a Mayo Clinic study presented at the American Transplant Congress under way May 1-5 in San Diego.
May 2, 2010 - 4:00:00 AM
Extracorporeal liver support therapy shows promise for severely ill patients
Results from two studies presented on 16th April 2010 at the International Liver Congress 2010 have shown that treatment with extracorporeal devices may not confer a survival advantage for severe liver failure patients, despite positive dialysis effects. However, results among a small sub-group of patients show promise.
Apr 18, 2010 - 12:49:40 PM
Keeping the weight off after a very low-energy diet
Simple advice can reduce the risk of weight regain after a very-low-energy diet: the secret to keeping the weight off is to switch back to normal food gradually, reveals a dissertation from the Sahlgrenska Academy, at the University of Gothenburg, Sweden, which also contains new research results for patients who have undergone obesity surgery.
Apr 4, 2010 - 4:00:00 AM
Demographic profile suggests environmental role in etiology of Crohn's Disease
A research team from the United Kingdom determined the hospitalized prevalence of severe IBD and subsequent 5-year mortality in Wales, and investigated associations between severe IBD and social deprivation, distance travelled to hospital, and other socio-demographic characteristics.
Feb 6, 2010 - 12:58:48 PM
A novel and simple formula to predict treatment success in chronic hepatitis C
The likelihood of treatment success of 48 wk peg-interferon (PEG-IFN) plus ribavirin (RBV) therapy for chronic hepatitis C may be predicted by viral kinetics on therapy. In particular, recent studies have shown that sustained virological response (SVR) can be predicted by a rapid virological response (RVR), and an early virological response (EVR). Nevertheless, the current dosing regimens could potentially under-treat some patients and additional measurements of viral response is needed to facilitate individualization of therapy. Among predictive factors already reported, many are not readily available from daily clinical assessment, because they require genomic analyses and/or advanced experimental methods. The prediction with simply available data may be useful.
Jan 14, 2010 - 5:00:00 AM
Fat in the liver -- not the belly -- is a better marker for disease risk
New findings from nutrition researchers at Washington University School of Medicine in St. Louis suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver.
Aug 24, 2009 - 4:00:00 AM
Sequential TACE and cryosurgery can improve survival times for patients with HCC?
Hepatocellular carcinoma (HCC)--a liver cancer--is recognized as one of the most common cancers in the world that disproportionately affects Southeast Asians and Africans. While there are therapies that possibly provide a cure, surgical removal and liver transplantation are invasive and radical options. However, even these approaches only benefit a small proportion of the total number HCC patients. Cryosurgery is a minimally invasive technique of using extreme low temperatures to freeze and kill tumors, improve patient' survival times, and reduce surgical complications. Cryosurgery can be potentially applied to any surgery for solid organ cancers where conventional surgery would otherwise be used to remove undesirable tissue. It is anticipated that in the near future, cryosurgery will increasingly replace the use of traditional techniques of ablation.
Aug 11, 2009 - 4:00:00 AM
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively referred to as IBD.
Jun 2, 2009 - 4:00:00 AM
No longer afraid to be a bridesmaid or travel with the boss
CHICAGO --- One of Laurie Keefer's patients was afraid to be a bridesmaid in a friend's wedding, others worried about traveling with the boss or even going to parties in peoples' homes.
May 13, 2009 - 4:00:00 AM
UIC researchers measure health effects of Chicago's waterways
Researchers at the University of Illinois at Chicago School of Public Health are conducting a study to determine the health effects associated with recreational activities such as boating, canoeing, kayaking and fishing on Chicago's waterways.
Mar 23, 2009 - 4:00:00 AM
Putting a name to the fluke
In a world first, a UQ researcher has developed a non-invasive screening method for potentially fatal liver and intestinal flukes plaguing the lives of an estimated 9 million people throughout southeast Asia.
Feb 11, 2009 - 5:00:00 AM
14.6% of patients with Iron deficiency anaemia of obscure origin have gluten sensitive enteropathy (GSE
A research team led by Prof. Reza Malekzadeh studied the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. Their findings will be published on December 28, 2008 in the World Journal of Gastroenterology.
Dec 31, 2008 - 8:13:26 AM
Novel IBS treatment developed at UB garners $8.5 million for seven-year clinical trial
BUFFALO, N.Y. -- Irritable bowel syndrome is a chronic, debilitating disorder affecting 25 million people in the U.S -- 14-24 percent of women and 5-19 percent of men.
Nov 13, 2008 - 5:00:00 AM
Factors for developing IPF in Hepatitis C patients
There is little or no information on the yearly cumulative incidence and risk factors on the development rate of Idiopathic pulmonary fibrosis in patients with HCV.A research team led by Yasuji Arase from Toranomon Hospital of Japan addresses this, and the study will be published on October 14, 2008 in the World Journal of Gastroenterology.
Oct 23, 2008 - 2:12:44 PM
Children's Hospital of Pittsburgh of UPMC scientific director elected to Institute of Medicine
David H. Perlmutter, MD, scientific director and physician-in-chief at Children's Hospital of Pittsburgh of UPMC, has been elected to the prestigious Institute of Medicine (IOM).
Oct 13, 2008 - 4:00:00 AM
Endoscopy not needed in asymptomatic children after caustic ingestion
A new study from researchers in Italy reports that endoscopy may not be necessary in children who show no symptoms after a caustic ingestion. The results demonstrated that the incidence of severe abnormalities of the esophagus in children without any early symptoms is very low and an endoscopy could be avoided.
Sep 26, 2008 - 11:52:29 PM