|Last Updated: Nov 2, 2013 - 11:52:55 AM
Researchers construct erectile tissue in rabbits
The day is not far off when surgeons will be able to reconstruct or replace damaged or diseased penile tissue in humans and enable them to return to a normal life, says a new study.
Nov 23, 2009 - 5:25:31 PM
First Demonstration of New Hair Follicle Generation
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate.
May 17, 2007 - 8:25:51 AM
Early stage sperm cells created in laboratory
Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created.
Apr 14, 2007 - 6:17:32 AM
Faults in housekeeping genes regulating protein trafficking results in skeletal deformities
A defective link in the intracellular protein "transit system" may lie at the heart of some craniofacial defects, new research in zebrafish suggests.
Sep 19, 2006 - 3:01:00 PM
Neural stem cells derived from human embryonic stem cells carry abnormal gene expression
Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.
Researchers from the Institute for Stem Cell Biology and Medicine at UCLA coaxed cells from the federally approved line to differentiate into neural stem cells, a process that might one day be used to grow replacement cells to treat such debilitating diseases as Parkinson's and Alzheimer's. However, the neural stem cells expressed a lower level of a metabolic gene called CPT 1A, a condition that causes hypoglycemia in humans.
Aug 6, 2006 - 6:47:00 AM
Neurons grown from embryonic stem cells restore function in paralyzed rats
For the first time, researchers have enticed transplants of embryonic stem cell-derived motor neurons in the spinal cord to connect with muscles and partially restore function in paralyzed animals. The study suggests that similar techniques may be useful for treating such disorders as spinal cord injury, transverse myelitis, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy. The study was funded in part by the NIH's National Institute of Neurological Disorders and Stroke (NINDS). The researchers, led by Douglas Kerr, M.D., Ph.D., of The Johns Hopkins University School of Medicine, used a combination of transplanted motor neurons, chemicals capable of overcoming signals that inhibit axon growth, and a nerve growth factor to attract axons to muscles. The report is published in the July 2006 issue of Annals of Neurology.
Jun 21, 2006 - 12:45:00 AM
New stem-cell findings can help the body to cure itself
Researchers at Karolinska Institutet have identified an important mechanism that regulates how many new cells are produced by each intestinal stem cell. The study is published in the latest issue of the prestigious scientific journal, Cell. "This might eventually help us develop new drugs for things like neurological disorders and anaemia," says Professor Jonas Frisén.
Jun 16, 2006 - 12:49:00 AM
Putting avian transgenics on a par with transgenic mice
Origen Therapeutics announced today that it has succeeded in developing a robust and versatile technology for genetically modifying chickens that, for the first time, puts avian transgenics on a par with transgenic mice. The company made the announcement in conjunction with the publication of an article this week by Origen scientists and a collaborator from the University of California, Davis on its transgenic technology in the journal Nature. Using the new technology, Origen can, in principle, make any genetic modification desired to the chicken genome, including the insertion of genetic elements for the production of human therapeutics and the modification of the chicken immune system to produce novel human sequence polyclonal antibodies. Moreover, the new technology opens up the possibility of producing chickens with enhanced agronomic traits, including resistance to avian flu.
Jun 8, 2006 - 7:43:00 AM
Harvard to Create Human Embryonic Stem Cell Lines
After more than two years of intensive ethical and scientific review, Harvard Stem Cell Institute (HSCI) researchers at Harvard and Children's Hospital Boston have been cleared to begin experiments using Somatic Cell Nuclear Transfer (SCNT) to create disease-specific stem cell lines in an effort to develop treatments for a wide range of now-incurable conditions afflicting tens of millions of people.
Jun 7, 2006 - 7:57:00 PM
Stem Cell Study for Patients with Heart Attack Damage Seeks to Regenerate Heart Muscle
Rush cardiologists are hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue.
Apr 22, 2006 - 7:16:00 PM
Stem cells - An alternative to skin grafting?
A Singapore company has used stem cells to help victims of serious burns and other wounds grow fresh skin, its chief medical officer said in a report published Friday.
Apr 7, 2006 - 1:46:00 PM
Bone morphogenetic protein 6 (BMP-6) factor stimulates cartilage growth from stem cells
A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.
Apr 5, 2006 - 2:42:00 PM
Doctors grow organ from patients' own cells
For the first time in medical history, scientists have grown a human organ from patients' own cells to transplant back into their bodies.
Apr 5, 2006 - 2:16:00 PM
Stem cells can repair torn tendons or ligaments
Weekend athletes who overexert themselves running or playing basketball may one day reap the benefits of research at the Hebrew University of Jerusalem that shows that adult stem cells can be used to make new tendon or ligament tissue.
Apr 5, 2006 - 1:35:00 PM
New research could coax bone cells into produce up to 75 times more calcium
In a significant advance for regenerative medicine, researchers at Rice University have discovered a new way to culture adult stem cells from bone marrow such that the cells themselves produce a growth matrix that is rich in important biochemical growth factors.
Feb 14, 2006 - 5:13:00 PM
Stem cell injections may prove beneficial in treating peripheral artery disease
Indiana University School of Medicine scientists have begun a unique clinical trial using stem cell injections as a treatment that could offer hope to tens of thousands of people who face sores, ulcers and even amputations due to severe peripheral artery disease.
Feb 10, 2006 - 4:00:00 PM
New mechanism potentially explain evolution of signalling pathways
Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways.
Feb 8, 2006 - 11:19:00 AM
Hyperbaric oxygen treatments mobilize stem cells
According to a study to be published in the American Journal of Physiology-Heart and Circulation Physiology, a typical course of hyperbaric oxygen treatments increases by eight-fold the number of stem cells circulating in a patient's body. Stem cells, also called progenitor cells are crucial to injury repair. The study currently appears on-line and is scheduled for publication in the April 2006 edition of the American Journal. Stem cells exist in the bone marrow of human beings and animals and are capable of changing their nature to become part of many different organs and tissues. In response to injury, these cells move from the bone marrow to the injured sites, where they differentiate into cells that assist in the healing process. The movement, or mobilization, of stem cells can be triggered by a variety of stimuli including pharmaceutical agents and hyperbaric oxygen treatments. Where as drugs are associated with a host of side effects, hyperbaric oxygen treatments carry a significantly lower risk of such effects.
Jan 1, 2006 - 9:02:00 PM
Clinical trial to test stem cell approach for children with brain injury
A unique clinical trial will gauge the safety and potential of treating children suffering traumatic brain injury with stem cells derived from their own bone marrow starting early next year at The University of Texas Medical School at Houston and Memorial Hermann Children's Hospital.
Dec 23, 2005 - 3:07:00 AM
How stem cells become brain cells
Continued research could result in new therapies for those who suffer brain injury, Parkinson's disease and other conditions related to lost or damaged brain cells
Dec 15, 2005 - 4:12:00 PM
Human Brain Cells Grown Inside Mouse Skull
Previous studies have shown that undifferentiated human embryonic stem cells (hESC) can survive in the brains of laboratory rats with Parkinsons disease. But until now it was unclear whether hESCs can become fully functional members of the host animals neuronal architecture - a basic necessity if stem cells are ever to be used in medical treatments replenishing missing or damaged neurons in human patients with neurodegenerative diseases such as Parkinson's or Alzheimers disease. Now, research at the Salk Institute for Biological Studies indicates for the first time that hESCs mature into fully functional adult brain cells and integrate into the existing nervous system when these human cells are injected in the developing brains of two-week-old mouse embryos. The Salk researchers led by Fred H. Gage, Ph.D, professor and co-head of the Laboratory of Genetics at the Salk Institute, published their finding in this weeks Proceedings of the National Academy of Science.
Dec 13, 2005 - 3:29:00 PM
Stem cells may trigger bone cancer
Stem cells may cause some forms of bone cancer, University of Florida scientists report. The researchers are the first to identify a population of cells with characteristics of adult and embryonic stem cells in cultures derived from biopsies of patients' bone tumors. They describe their findings in this month's issue of the medical journal Neoplasia. "We're saying the cell of origin of these tumors may be very, very primitive," said C. Parker Gibbs, M.D., an associate professor of orthopaedic oncology and a member of the UF Shands Cancer Center. Gibbs collaborated with several UF scientists, including Dennis A. Steindler, Ph.D., director of UF's McKnight Brain Institute. Researchers elsewhere already have implicated stem cells in the development of leukemia, and Steindler's lab previously discovered stem-like cells in brain cancer. Others have identified these same cells in some breast cancers.
Nov 23, 2005 - 9:30:00 PM
Stem cells successfully grown into cartilage cells
Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation. Cartilage is the dense connective tissue usually found between bones to allow the smooth movement of joints. Research to be published in Tissue Engineering shows how the Imperial team directed embryonic stem cells to become cartilage cells. This could allow doctors to grow cartilage for transplantation for a number of injuries and medical problems, including sports injuries, new cartilage for people having hip replacements, and even for cosmetic surgery.
Nov 16, 2005 - 8:57:00 PM
Functional ion channels in human embryonic stem cells (ESCs) discovered
Researchers from Johns Hopkins have discovered the presence of functional ion channels in human embryonic stem cells (ESCs). These ion channels act like electrical wires and permit ESCs, versatile cells that possess the unique ability to become all cell types of the body, to conduct and pass along electric currents.
Oct 22, 2005 - 2:33:00 AM
New Approach Maintains Developmental Potential of Embryo
The generation of embryonic stem cell lines using an alternative approach that does not interfere with the developmental potential of embryos is possible. The research, which appears online (ahead of print) in the journal Nature, by ACT and its collaborators, describes a method of deriving stem cells in mice using a technique of single-cell embryo biopsy similar to that used in preimplantation genetic diagnosis (PGD) to test for genetic defects.
Oct 18, 2005 - 1:56:00 PM
Spinal cord injury treatment with neural stem cells
Researchers at the UC Irvine Reeve-Irvine Research Center have used adult human neural stem cells to successfully regenerate damaged spinal cord tissue and improve mobility in mice.
Sep 20, 2005 - 8:38:00 PM
SPECT/CT can trace stem cells destinations after being injected
A team of scientists from the Johns Hopkins Department of Radiology and Institute of Cell Engineering has used a non-invasive imaging technique, called SPECT/CT, to successfully trace stem cells destinations after being injected into the body to treat animal hearts damaged by myocardial infarction, or heart attack.
Sep 14, 2005 - 9:38:00 PM
A new link between stem cells and tumors
Scientists at the European Molecular Biology Laboratory [EMBL] in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona [IRB-PCB] have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in the on-line edition of Nature Genetics [September 4] shows that if key molecules aren't placed in the right locations within stem cells before they divide, the result can be deadly tumors.
Sep 14, 2005 - 3:38:00 AM
Full cascade of events during fertilization tracked for first time
Researchers have capitalized on the unique properties of a sperm cell to follow cell membrane fusion as it occurs during fertilization, tracking the full cascade of events for the first time. The findings could reveal new ways to enhance or block fertilization, as well as how to control the secretion of neurotransmitters and hormones such as insulin.
Sep 6, 2005 - 6:41:00 AM
Some cancers originate with defects in stem cells
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in the on-line edition of Nature Genetics (September 4) shows that if key molecules aren't placed in the right locations within stem cells before they divide, the result can be deadly tumors.
Sep 6, 2005 - 6:34:00 AM
Challenging the accepted theory of stem cell operation in kidney repair
Paracrine cell signaling, not differentiation, appears to be how stem cells work in initial phase of organ protection, repair
Sep 4, 2005 - 9:10:00 AM
Adipose tissue stem cells could be used to treat injured or damaged tissues
National and international scientists, including those from the University of Virginia Health System, will announce findings from a significant number of studies showing that adult stem cells from adipose tissue (fat) could eventually be used to treat injured or damaged tissues. They will present their research findings at the Omni Hotel in Charlottesville, Virginia, September 10-13, during the third annual International Fat Applied Technology Society conference, The Role of Adipose Tissue in Regenerative Medicine: Opportunities for Clinical Therapy. Reporters are invited to attend and a press room will be open to meet their needs.
Sep 4, 2005 - 8:24:00 AM
Fusing adult somatic cells with embryonic stem cells - New Technique
Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.
Aug 22, 2005 - 9:41:00 PM
Method to produce symmetrical divisions of mouse brain stem cells derived from ES cells
In all the hullabaloo about stem cells, nobody has noted their uncanny similarity to pizza dough. You can divide either into two or four or eight identical pieces, but that doesnt determine what kind of cell or pizza you're going to make. But once you let a cell grow hundreds of nuclei, or you pile on the pepperoni, youre on your way to making a skeletal muscle fiber or a pepperoni pizza. If you want a white blood cell or an all-veggie pie, youre out of luck. The commitment to becoming a certain cell type is called differentiation.
Aug 19, 2005 - 6:52:00 PM
Producing embryonic-like cells from umbilical cord blood
A breakthrough in human stem cell research, producing embryonic-like cells from umbilical cord blood may substantially speed up the development of treatments for life-threatening illnesses, injuries and disabilities. The discovery made during a project undertaken with experts from the University of Texas Medical Branch and the Synthecon Corporation in the United States provides medical researchers and physicians with an ethical and reliable source of human stem cells for the first time.
Aug 18, 2005 - 1:39:00 PM
Promising cells similar to embryonic stem cells from amnion
Routinely discarded as medical waste, placental tissue could feasibly provide an abundant source of cells with the same potential to treat diseases and regenerate tissues as their more controversial counterparts, embryonic stem cells, suggests a University of Pittsburgh study to be published in the journal Stem Cells and available now as an early online publication in Stem Cells Express.
Aug 6, 2005 - 4:53:00 PM
Study - how cells become specialized for secretion
Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit flys salivary gland and its skin-like outer layer.
Jul 27, 2005 - 1:20:00 PM
New chemical to accelerate stem cell mobilization
The finding has led to the development of a new chemical compound that can accelerate this process (called stem cell mobilization) in mice--which could eventually lead to more efficient stem cell harvesting for human use.
Jul 27, 2005 - 1:16:00 PM
Fog2 Is Required for Normal Diaphragm and Lung Development in Mice and Humans
Birth defects involving the diaphragm are as common and as serious as genetic disorders such as cystic fibrosis, yet the underlying causes of these defects are unknown. Most babies born with diaphragmatic defects have very small lungs, and many die in the newborn period with severe breathing difficulties.
Jul 25, 2005 - 5:13:00 PM
Discovery of adult stem cells in the uterus
Monash Institute of Medical Research (MIMR) senior scientist Dr Caroline Gargett's discovery of adult stem cells in the uterus that can be grown into bone, muscle, fat and cartilage, has been hailed as a major medical and scientific development by international reproduction experts.
Jul 22, 2005 - 4:44:00 PM
Does the Heart Contain Stem Cells?
Steven Houser, Ph.D., Director of Cardiovascular Center for Temple University School of Medicine and Senior Associate Dean of Research, is sold on the idea that the heart - like the skin - contains its own stem cells: cells that are self-renewing and can be differentiated into different types of heart tissue. It's a controversial subject in cardiovascular circles, but for Houser, who spent thirty years studying the molecular biology of heart cells, the stakes are worth it when it comes to combating congestive heart failure (CHF).
Jul 22, 2005 - 12:55:00 AM
Unlimited mesenchymal precursor cells derived from human embryonic stem cell
According to research published today, investigators from Memorial Sloan-Kettering Cancer Center (MSKCC) have used new techniques in the laboratory that allowed them for the first time to derive unlimited numbers of purified mesenchymal precursor cells from human embryonic stem cells (HESCs). Mesenchymal precursor cells are capable of giving rise to fat, cartilage, bone, and skeletal muscle cells, and may potentially be used for regenerative stem cell therapy in bone, cartilage, or muscle replacement.
Jun 28, 2005 - 1:06:00 AM
Human embryonic stem cells have the capacity to develop into eggs or sperm
Scientists in the UK have proved that human embryonic stem cells can develop in the laboratory into the early forms of cells that eventually become eggs or sperm. Their work opens up the possibility that eggs and sperm could be grown from stem cells and used for assisted reproduction, therapeutic cloning and the creation of more stem cells for further research and for the improved treatments for patients suffering from a range of diseases.
Jun 20, 2005 - 4:32:00 PM
Transplanted Spermatogonial Stem Cells Restores Fertility after Chemotherapy
Now, in a study appearing online on June 16 in advance of print publication in the July 1 issue of the Journal of Clinical Investigation, Akira Tsujimura and colleagues from Osaka University describe a way in which healthy germ cells, including spermatogonial stem cells, can be distinguished and completely separated from leukemic cells in mice, and then harvested and preserved.
Jun 20, 2005 - 10:44:00 AM
Canada's first two human embryonic stem cell lines developed
A senior scientist at Mount Sinai Hospital has developed Canada's first two human embryonic stem cell lines, giving researchers across the country new potential and hope for eventually discovering treatments and cures for many chronic and fatal diseases.
Jun 9, 2005 - 6:08:00 PM
Stem cell breakthrough in UK
Newcastle University scientists have taken a major step forward in stem cell research, putting Britain in the vanguard of technology that could produce treatments for a range of conditions such as diabetes, Parkinsons disease and spinal injuries.
May 21, 2005 - 2:35:00 PM
Oligodendrocyte Progenitors Show Functional Improvements in Spinal Cord Injuries
Geron Corporation (Nasdaq:GERN) announced today the publication of studies showing that oligodendrocyte progenitors, differentiated from human embryonic stem cells (hESCs), produce functional improvements in rats with spinal cord injuries. These studies provide proof of concept for the therapeutic potential of differentiated hESCs in the treatment of neurological disorders such as spinal cord injury.
May 11, 2005 - 6:54:00 PM
Human Eggs Can Develop In Vitro
Research has shown for the first time that human eggs may develop directly from cultured ovarian surface epithelium (OSE) cells derived from adult human ovaries. Oocytes derived from the culture of OSE cells developed in vitro into mature eggs suitable for fertilization and development into an embryo. These findings, published today in the Open Access journal Reproductive Biology and Endocrinology, offer important new strategies for use in in vitro fertilization and stem cell research, and cast doubt on the established dogma on the fetal origin of eggs in adult human ovaries.
May 5, 2005 - 11:37:00 PM
Oogenesis in Cultures Derived from Adult Human Ovaries
Ten years ago, we reported that in adult human females the ovarian surface epithelium (OSE) is a source of germ cells. Recently, we also demonstrated that new primary follicles are formed by assembly of oocytes with nests of primitive granulosa cells in the ovarian cortex. The components of the new primary follicles, primitive granulosa and germ cells, differentiated sequentially from the OSE, which arises from cytokeratin positive mesenchymal progenitor cells residing in the ovarian tunica albuginea. In the present study, we investigated the possibility that the oocytes and granulosa cells may differentiate in cultures derived from adult human ovaries. Cells were scrapped from the surface of ovaries and cultured for 5 to 6 days, in the presence or absence of estrogenic stimuli [phenol red (PhR)]. The OSE cells cultured in the medium without PhR differentiated into small (15 micron) cells of granulosa phenotype, and epithelial, neural, and mesenchymal type cells. In contrast, OSE cells cultured in the presence of PhR differentiated directly into large (180 micron) cells of the oocyte phenotype. Such cells exhibited germinal vesicle breakdown, expulsion of the polar body, and surface expression of zona pellucida proteins, i.e. characteristics of secondary oocytes. These in vitro studies confirm our in vivo observations that in adult human ovaries, the OSE is a bipotent source of oocytes and granulosa cells. Development of numerous mature oocytes from adult ovarian stem cells in vitro offers new strategies for the egg preservation, IVF utilization, and treatment of female infertility. In addition, other clinical applications aiming to utilize stem cells, and basic stem cell research as well, may employ totipotent embryonic stem cells developing from fertilized oocytes.
May 5, 2005 - 8:39:00 PM
A Developmental Switch in Neuronal Differentiation
Building an embryo is like building a house: everything has to be done at the right time and the right place if the plans are to be translated faithfully. On the building site, if the roofer comes along before the bricklayer has finished, the result may be a bungalow instead of a two-story residence. In the embryo, if the neurons, for example, start to make connections prematurely, the resultant animal may lack feeling in its skin.
Apr 27, 2005 - 2:27:00 AM