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Latest Research : Nephrology
  Last Updated: Nov 2, 2013 - 11:52:55 AM

Latest Research : Nephrology
Renal biomarkers predict risk of acute kidney injury following surgery in two large studies
Three protein measurements- including urine interleukin-18 (IL-18) and urine and plasma (blood) neutrophil gelatinase-associated lipocalin (NGAL)—indicate who has a high risk of developing kidney injury after heart surgery, according to two studies appearing in an upcoming issue of the Journal of the American Society of Nephrology.


Aug 13, 2011 - 8:03:30 PM

Latest Research : Nephrology : Dialysis
Intradialytic hypotension associated with increased incidence of haemodialysis vascular access thrombosis
A study published online on July 29 in the Journal of the American Society of Nephrology reports an increased risk of thrombus(clot) formation in the vascular access which is used for haemodialysis as a consequence of intradialytic hypotension(low blood pressure during dialysis).
Jul 30, 2011 - 7:42:44 PM

Latest Research : Nephrology
Mouse model shows that kidney-specific dopamine system important for kidney function and blood pressure regulation
Vanderbilt University Medical Center investigators have demonstrated in a mouse model that dopamine produced outside the brain – in the kidneys – is important for renal function, blood pressure regulation and life span.
Jul 19, 2011 - 6:19:38 PM

Latest Research : Nephrology
Blood pressure control system in distal nephron
Scientists at The University of Texas Health Science Center San Antonio demonstrated that sodium handling by the distal nephron is under the control of a local regulatory system.

Jan 14, 2011 - 9:44:46 PM

Latest Research : Nephrology
Adherence to cardiac medication less in renal patients
Among older adults with a recent heart attack (myocardial infarction), those with lower levels of kidney function are less likely to take their medications as prescribed, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

Jan 13, 2011 - 8:22:58 PM

Latest Research : Nephrology
Higher Leptin levels associated with lower bone turnover in Renal transplant patients
A study published in the December issue of Clinical Journal of the American Society of Nephrology looked at the effect of adipose tissue on bone turnover through leptin production in kidney transplant recipients.


Dec 27, 2010 - 9:38:40 AM

Latest Research : Nephrology
Vegetarian diets help renal patients to lower serum phosphorus and FGF-23 levels
Phosphorous levels and FGF23 levels are lower in kidney disease patients who stick to a vegetarian diet, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).
Dec 27, 2010 - 9:09:41 AM

Latest Research : Nephrology
SHARP trial shows benefit of cholesterol-lowering in Chronic Kidney Patients
The findinds of the SHARP trial indicate that round a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by using the combination of ezetimibe and simvastatin to lower blood cholesterol levels.
Dec 22, 2010 - 12:16:39 AM

Latest Research : Nephrology : Dialysis
Low Phosphate diet not helpful in dialysis patients
Doctors often ask kidney disease patients on dialysis to limit the amount of phosphate they consume in their diets, but this does not help prolong their lives, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results even suggest that prescribing low phosphate diets may increase dialysis patients' risk of premature death.



Dec 10, 2010 - 8:34:21 AM

Latest Research : Nephrology
Poor kidney function in HIV- infected drug users
Poor kidney function is common among injection drug users, particularly those with HIV, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology.
Aug 14, 2010 - 9:41:35 PM

Latest Research : Nephrology
Belatacept may preserve renal function better than calcineurin inhibitors in kidney transplantation
Initial results of a study conducted at 100 centers worldwide indicate that belatacept, a first-in-class costimulation blocker can prevent the immune system rejecting new organs. The results also suggest that it may provide similar patient and graft survival to cyclosporine but with fewer side effects and superior kidney function after 12 months.
Mar 9, 2010 - 2:30:15 PM

Latest Research : Nephrology
Bone mineral density loss faster in those with kidney disease
Even slight kidney impairment can speed up the loss of bone mineral density (BMD) among older people, putting them at risk of potentially disabling fractures, new research shows.
Feb 6, 2010 - 3:20:32 PM

Latest Research : Nephrology
Proteinuria, in addition to decreased glomerular filtration rate, has adverse outcomes
Patients with high levels of proteinuria (protein in urine) in addition to another marker of reduced kidney function had an associated increased risk of all-cause death, heart attack or progression to kidney failure, according to a study in the February 3 issue of JAMA.
Feb 2, 2010 - 2:13:14 PM

Latest Research : Nephrology
Hypertension often missed in children with renal disease
Blood pressure readings in children with chronic kidney disease often fail to detect hypertension – even during doctor’s office visits — increasing a child’s risk for serious heart problems, according to research from Johns Hopkins Children’s Center and other institutions.
Nov 22, 2009 - 8:57:34 AM

Latest Research : Nephrology
Eculizumab prevents kidney transplant rejection by inhibiting activation the complement system
Early results from a Mayo Clinic research study demonstrate the effectiveness of a new approach to blocking an important part of the immune system that causes severe damage to some kidney transplants. Historically, these patients have been very difficult to treat successfully because their immune systems are already primed with antibodies to destroy the donor organ. These findings were presented today at the American Transplant Congress.
Jun 2, 2009 - 2:25:59 PM

Latest Research : Nephrology
Three-variable and five-variable equations for eGFR recommended for pre-operative patients
A research team led by Dr. Tokihiko Sawada from Dokkyo Medical University, Japan retrospectively calculated the preoperative three-variable and five-variable equations for eGFR, and compared the results with Ccr in patients undergoing hepatectomy.

May 24, 2009 - 10:26:10 AM

Latest Research : Nephrology : Dialysis
Nephrologist care prior to starting dialysis reduces risk of death
For patients with end-stage renal disease (ESRD), receiving care from a nephrologist in the months before starting dialysis reduces the risk of death during the first year on dialysis, reports a study in the May 2009 issue of the Journal of the American Society of Nephrology (JASN).
Mar 25, 2009 - 4:13:58 PM

Latest Research : Nephrology
Women drinking 2 or more cans of soda are at risk of albuminuria
Women who drink two or more cans of soda pop per day are nearly twice as likely to show early signs of kidney disease, a recent study has found.However, researchers did not find an elevated risk for men, or for people who drink diet soda, said lead researcher David Shoham of Loyola University Health System.
Feb 9, 2009 - 11:52:34 AM

Latest Research : Nephrology : Dialysis
Lower death rate in dialysis patients living at higher altitude
Compared to dialysis patients living near sea level, dialysis patients living at an altitude higher than 4,000 feet have a 12-15 percent lower rate of death, according to a study in the February 4 issue of JAMA.
Feb 3, 2009 - 11:16:02 PM

Latest Research : Nephrology
Normograms to predict long-term outcomes in renal transplants
In a study published in the March 2009 issue of The Journal of Urology, researchers report on the development and validation of three nomograms that can reliably predict long-term outcomes.
Jan 24, 2009 - 4:43:01 PM

Latest Research : Nephrology : Dialysis
Clear advantage of high efficacy Haemodiafiltration over conventional hemodialysis
Suffering from end-stage renal disease (ESRD), a growing number of patients at the Centre hospitalier de l'Université de Montréal (CHUM), have become the beneficiaries of a North American breakthrough: high efficacy hemodiafiltration (HDF).
Nov 29, 2008 - 3:19:20 AM

Latest Research : Genetics
Atlas of kidney genome created
A comprehensive genome-based atlas, created by researchers, would help shed light on healthy and abnormal kidney development and disease. The atlas shows how the entire genome is regulated to produce thousands of specific genes that are mixed and re-mixed to form genetic teams.

Nov 13, 2008 - 10:43:26 AM

Latest Research : Nephrology
NICE issues guidelines for chronic kidney disease- early identification and management
The new National Institute for Health and Clinical Excellence (NICE) guidelines for the management of early kidney disease were issued on the 24th of September 2008. It focuses on the early identification of renal disease in high risk individuals (i.e. in patients with diabetes mellitus, hypertension, multisystem disorders, cardiovascular disease and those with family history of kidney disease), management of risk factors and early kidney disease and appropriate referral for specialist care.
Sep 27, 2008 - 8:17:58 AM

Latest Research : Nephrology
Night-time kidney transplants less successful
Kidney transplants should be carried out during the day if possible. At least this is the conclusion suggested by a survey just published by urologists and internists at the University of Bonn
Jul 15, 2008 - 12:37:38 PM

Latest Research : Nephrology
AVOID study shows Aliskiren decreasing albuminuria
The much awaited results of the AVOID (Aliskiren in the eValuation of prOteinuria In Diabetes) study were published in the June 5th edition of the New England Journal of Medicine. It is the first study which looked at the kidney-protective benefits of Aliskiren, independent of its proven blood pressure reductions.
Jun 12, 2008 - 11:35:31 AM

Latest Research : Nephrology
ASTRAL Trial-Angioplasty and stenting offer no benefit over medical therapy
The largest-ever randomized study to evaluate the effectiveness of catheter-based interventions in patients with narrowing of the renal artery has shown that angioplasty and stenting offer no benefit over medical therapy. Among patients who completed one year of follow-up, there were no differences in the change in kidney function, blood pressure control or the rates of major cardiovascular illness, according to the Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) trial.
Apr 1, 2008 - 1:44:28 PM

Latest Research : Nephrology
Renal patients still being referred late
Some patients with kidney disease aren’t referred to kidney specialists in time to delay disease progression and improve their prognosis for a variety of reasons, according to researchers at Wake Forest University School of Medicine and colleagues.
Mar 2, 2008 - 3:09:50 AM

Latest Research : Nephrology
Emory algorithm helps improve kidney transplant chances
Approximately one-third of the patients on the national waiting list for kidney transplants have only a small chance of receiving a new organ, no matter how long they are on the list. Due to prior transplants, pregnancies or blood transfusions, these patients have developed antibodies that make it very difficult to match them with donor organs.
Researchers at Emory University have developed a decision process, based on innovative technology, that may help to level the transplant playing field and give new hope to these "highly sensitized patients." The Emory Algorithm, as this new method is known, may even change the way kidneys from deceased donors are allocated in the United States.

Mar 2, 2007 - 11:51:45 AM

Latest Research : Nephrology
Kidney stones? Have some orange juice!!!
A daily glass of orange juice can help prevent the recurrence of kidney stones better than other citrus fruit juices such as lemonade, researchers at UT Southwestern Medical Center have discovered.
Sep 1, 2006 - 5:14:00 PM

Latest Research : Nephrology
NOTCH2 gene mutations linked to Alagille syndrome
In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs. The Children's Hospital team previously discovered the first gene associated with this disease.
Aug 1, 2006 - 1:30:00 PM

Latest Research : Nephrology
Fetal hydronephrosis mystery solved
Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line. Scientists have known of the mouse line's naturally occurring mutation since the early 1970s. Researchers at Washington University School of Medicine in St. Louis are the first to identify the mutated gene, allowing them to determine the mutation's effects and the origins of the disease.
May 3, 2006 - 12:14:00 AM

Latest Research : Nephrology
Alport Syndrome: From Pathogenesis to a Potential Therapy
In 1927, Cecil Alport described a family in which affected individuals developed progressive kidney failure, deafness, and sometimes eye problems. Alport syndrome, although it affects only one in 50,000 live births in the United States, is the second most commonly inherited reason for kidney failure. It is caused by mutations in the genes that encode type IV collagen, a structural component of the thin, sheet-like basement membrane that covers the glomeruli, the kidney's filtration units. The glomerular basement membrane (GBM) normally filters fluid and small molecules (but not proteins or red blood cells) from the capillaries in the glomeruli into the urine, but in Alport syndrome, the collagen scaffold of the GBM is defective and, over time, the GBM splits and thins. The first symptom of Alport syndrome is blood in the urine (hematuria), followed by proteinuria and progressive renal failure as scar tissue (fibrotic tissue) forms around the glomeruli. The syndrome has no specific treatment, but kidney transplantation is usually successful in patients with end-stage kidney failure.
Mar 8, 2006 - 5:07:00 AM

Latest Research : Nephrology
Meckel-Gruber syndrome gene identified- a help to understand polycystic kidney disease
An international research collaboration led by Mayo Clinic has identified a new gene involved in causing the inherited kidney disorder, Meckel-Gruber syndrome (MKS). Children with MKS have central nervous system deformities as well as abnormal cysts in their kidneys, and usually die shortly after birth.
Jan 17, 2006 - 2:10:00 AM

Latest Research : Nephrology : Dialysis
Dialysis patients may be overmedicated
Changes in a widely used assay (blood test) for parathyroid hormone (PTH) have made its use with the established guidelines for end stage renal disease clinical management both inappropriate and potentially harmful to patients. This research is published in the journal Seminars in Dialysis.
Nov 30, 2005 - 3:35:00 PM

Latest Research : Nephrology
Mycophenolate mofetil may be more effective in inducing lupus nephritis remission
Treating lupus patients suffering from kidney inflammation with a medicine known as mycophenolate mofetil may be more effective in inducing remission than treating them with the standard regimen of intravenous cyclophosphamide (Cytoxan), a new clinical trial indicates. The study, published in Thursday’s issue (Nov. 24) of the New England Journal of Medicine, also showed that mycophenolate mofetil produced fewer complications, researchers found.
Nov 25, 2005 - 6:22:00 AM

Latest Research : Nephrology : Dialysis
Dialysis patients often have close family members also on dialysis - Study
Nearly one-fourth of all dialysis patients have a close relative on dialysis, researchers at Wake Forest University Baptist Medical Center, and others, report in the current online edition of the American Journal of Nephrology. The researchers suggest screening other relatives for undetected kidney disease.
Nov 2, 2005 - 12:12:00 PM

Latest Research : Nephrology
Prognosis Improving For Diabetics With End Stage Renal Disease
Patients with type 1 diabetes have an improved prognosis with regard to end-stage renal disease over the past four decades, and it appears the incidence of end-stage renal disease is lower than previously estimated, according to a study in the October 12 issue of JAMA.
Oct 14, 2005 - 9:55:00 PM

Latest Research : Nephrology
Osmolytes critical to survival of kidney cells
Researchers at the University of Texas Medical Branch at Galveston (UTMB) have developed a new way to predict the ability of certain small molecules to protect proteins in the cells of a wide variety of organisms living in extreme environments. The technique, described in a paper published online Oct. 7 in the Proceedings of the Natural Academy of Sciences (PNAS), is a method of calculating the stabilizing effect on cellular proteins by small organic molecules called "osmolytes." It could have implications for the study of Alzheimer's disease, cystic fibrosis, kidney disease and stabilizing protein drugs.
Oct 8, 2005 - 5:40:00 AM

Latest Research : Nephrology
Study Examines Global Prevalence Of Kidney Failure Among Critically Ill Patients
A multinational study has found that 5 to 6 percent of patients in intensive care units experience acute kidney failure, and about 60 percent of these patients die in the hospital, according to an article in the August 17 issue of JAMA.
Aug 17, 2005 - 9:59:00 PM

Latest Research : Nephrology
"gold standard" of open surgery for kidney tumors should remain the first choice
Urologists often view less-invasive surgery techniques as more desirable for the patient, but in a study of open nephron-sparing surgeries (NSS) from 1985 to 2001 at Mayo Clinic, researchers found that the "gold standard" of open surgery for kidney tumors should remain the first choice for many patients. The study appears online in The Journal of Urology.

Aug 10, 2005 - 12:22:00 PM

Latest Research : Nephrology
Chronic Kidney Disease Associated with "Benign" Prostate Obstruction
Men who experience signs and symptoms of a prostate obstruction resulting from benign prostatic hyperplasia (BPH) are three times more likely than other men to develop chronic kidney disease, according to findings of a Mayo Clinic study published in this month's edition of Kidney International.
Jun 29, 2005 - 1:00:00 PM

Latest Research : Nephrology
Unique therapeutic strategy for Chronic Kidney Disease (CKD)
Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia -- severe malnutrition and physical wasting away -- in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.
Jun 12, 2005 - 5:42:00 AM

Latest Research : Nephrology : Dialysis
Hemodialysis causes antioxidant loss leading to long-term complications
An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.
Apr 8, 2005 - 1:34:00 AM

Latest Research : Nephrology : Dialysis
Oxidative Stress in Dialysis Patients can Lead to Long-Term Health Problems
An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.
Apr 3, 2005 - 10:04:00 AM

Latest Research : Nephrology
KCP enhances signals from bone morphogenetic proteins that control kidney development and disease
Scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.
Mar 29, 2005 - 3:18:00 PM

Latest Research : Nephrology
Sulodexide Gelcaps : An Oral Heparinoid for the Treatment of Diabetic Nephropathy Gets Ready for Phase 3-4 Trial
Keryx Biopharmaceuticals, Inc. announced today that it has finalized a Special Protocol Assessment (SPA) agreement with the Food and Drug Administration (FDA) for the Phase 3 and Phase 4 clinical trials of KRX-101 (sulodexide gelcaps), the Company's drug candidate for the treatment of diabetic nephropathy.
Mar 17, 2005 - 8:03:00 AM

Latest Research : Nephrology
Age Should Not Be A Limiting Factor for Kidney Transplantation
Growing evidence suggests that age alone shouldn’t prevent older adults from being organ donors – or having a kidney transplant themselves – according to researchers at Wake Forest University Baptist Medical Center. The findings could help alleviate a serious shortage of organs for transplantation.
Mar 15, 2005 - 1:54:00 PM

Latest Research : Nephrology
Vitamin D May Significantly Improve Survival in Dialysis Patients
The administration of intravenous vitamin D appears to significantly improve the survival of patients on dialysis, according to a study that will be published in the April Journal of the American Society of Nephrology and has been released ahead of print on the journal's website. Vitamin D injections are currently recommended only for dialysis patients with elevated levels of parathyroid hormone, but the report from a Massachusetts General Hospital (MGH)-based research group suggests that the treatment might help most dialysis patients live longer.
Mar 13, 2005 - 8:34:00 AM

Latest Research : Nephrology
BMP-7 Prevents Renal Osteodystrophy and Vascular Calcification Associated with Chronic Renal Disease
The investigators demonstrate that BMP-7 treatment prevents renal osteodystrophy and vascular calcification by stimulating the rate of skeletal mineralization, thereby diverting mineral that might have been deposited inappropriately in the blood vessels.
Mar 13, 2005 - 8:26:00 AM

Latest Research : Nephrology
LEA29Y (belatacept) effectively preserves kidneys during transplants
Emory University physician-researchers in Atlanta have shown an investigational medication, known as LEA29Y (belatacept), is effective in preserving transplanted kidney function while at the same time avoiding the toxic side effects that are common in the currently used long-term, immunosuppressive transplant medications. The pre-clinical research conducted with nonhuman primates at the Yerkes National Primate Research center was an important step in establishing human clinical trials to develop an effective alternative to current anti-rejection therapies.
Feb 23, 2005 - 8:04:00 PM

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