RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
  Dialysis
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Research Article
Nephrology Channel

subscribe to Nephrology newsletter
Latest Research : Nephrology

   EMAIL   |   PRINT
Normograms to predict long-term outcomes in renal transplants

Jan 24, 2009 - 4:43:01 PM , Reviewed by: Dr. Sanjukta Acharya

 
[RxPG] Kidney transplants are the best available therapy for end stage renal disease. Because of the shortage of deceased organ donors, living donor transplantation is rapidly growing and has the advantage of improved outcomes over deceased donor transplants. In fact, a transplant candidate may now have several potential living donors and the clinician may need to identify which donor would yield the best results. In a study published in the March 2009 issue of The Journal of Urology, researchers report on the development and validation of three nomograms that can reliably predict long-term outcomes.

A nomogram is an objective tool that uses an algorithm or mathematical formula to predict the probability of an outcome. Nomograms have been shown to outperform clinicians in predicting oncological outcomes and may be of benefit in certain decision-making settings. Nomograms can sift through the multitude of donor and recipient parameters that impact transplant outcome and help transplant physicians to better counsel their patients.

Using records from over 20,000 living donor transplant cases taken from the United Network for Organ Sharing (UNOS) registry, investigators from the Renal Transplantation Program, Glickman Urological & Kidney Institute at the Cleveland Clinic identified 18 characteristics, such as donor and recipient ages, donor serum creatinine levels and the cause of the recipient's renal failure. By using the value of each factor to determine a point score and totaling all of the points, the nomograms were able to predict kidney function 1 year after transplant and 5-year transplant survival. By adding 3 additional factors obtained 6 months after surgery, another nomogram was developed to refine the 5-year survival prediction.

Writing in the article, D. A. Goldfarb states, "Our work is consistent with the transplant physician community's efforts to develop better predictive tools...the nomograms developed in this study take this effort a step further by using a greater number of variables including early posttransplant information for better predictability and by attempting to predict specific outcome measures of renal function in addition to long term graft survival... These models can help to optimize the selection of living kidney donors. The prognostic information these models provide can help improve patient care."



Publication: The Journal of Urology

Advertise in this space for $10 per month. Contact us today.


Related Nephrology News
Renal biomarkers predict risk of acute kidney injury following surgery in two large studies
Intradialytic hypotension associated with increased incidence of haemodialysis vascular access thrombosis
Mouse model shows that kidney-specific dopamine system important for kidney function and blood pressure regulation
Blood pressure control system in distal nephron
Adherence to cardiac medication less in renal patients
Higher Leptin levels associated with lower bone turnover in Renal transplant patients
Vegetarian diets help renal patients to lower serum phosphorus and FGF-23 levels
SHARP trial shows benefit of cholesterol-lowering in Chronic Kidney Patients
Low Phosphate diet not helpful in dialysis patients
Poor kidney function in HIV- infected drug users

Subscribe to Nephrology Newsletter

Enter your email address:


 About Dr. Sanjukta Acharya
This news story has been reviewed by Dr. Sanjukta Acharya before its publication on RxPG News website. Dr. Sanjukta Acharya, MBBS MRCP is the chief editor for RxPG News website. She oversees all the medical news submissions and manages the medicine section of the website. She has a special interest in nephrology. She can be reached for corrections and feedback at [email protected]
RxPG News is committed to promotion and implementation of Evidence Based Medical Journalism in all channels of mass media including internet.
 Additional information about the news article
The article is "Nomograms for Predicting Graft Function and Survival in Living Donor Kidney Transplantation Based on the UNOS Registry" by H.Y. Tiong, D.A. Goldfarb, M.W. Kattan, J.M. Alster, L. Thuita, C. Yu, A. Wee and E.D. Poggio. It appears in The Journal of Urology, Volume 181, Issue 3 (March 2009) published by Elsevier.
 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)