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Last Updated: Sep 8, 2007 - 1:21:03 PM |
Latest Research
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Biotechnology
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Drug Delivery
Nanoparticles hitchhike on red blood cells for drug delivery
Researchers at the University of California, Santa Barbara have discovered that attaching polymeric nanoparticles to the surface of red blood cells dramatically increases the in vivo lifetime of the nanoparticles. The research, published in the July 07 issue of Experimental Biology and Medicine, could offer applications for the delivery of drugs and circulating bioreactors.
Jun 27, 2007 - 4:00:00 AM
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Latest Research
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Biotechnology
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Nanotechnology
Gold Nanoparticle Molecular Ruler to Measure Smallest of Lifes Phenomena
Scientists from the U.S. Department Energys Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley have developed a ruler made of gold nanoparticles and DNA that can measure the smallest of lifes phenomena, such as precisely where on a DNA strand a protein attaches itself.
Oct 12, 2006 - 1:23:00 PM
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Latest Research
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Biotechnology
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Nanotechnology
Tiny inhaled particles take easy route from nose to brain
In a continuing effort to find out if the tiniest airborne particles pose a health risk, University of Rochester Medical Center scientists showed that when rats breathe in nano-sized materials they follow a rapid and efficient pathway from the nasal cavity to several regions of the brain, according to a study in the August issue of Environmental Health Perspectives.
Aug 3, 2006 - 5:29:00 PM
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Latest Research
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Biotechnology
DNA Amplification and Detection Made Simple
Twenty-three years ago, a man musing about work while driving down a California highway revolutionized molecular biology when he envisioned a technique to make large numbers of copies of a piece of DNA rapidly and accurately. Known as the polymerase chain reaction, or PCR, Kary Mullis's technique involves separating the double strands of a DNA fragment into single-strand templates by heating it, attaching primers that initiate the copying process, using DNA polymerase to make a copy of each strand from free nucleotides floating around in the reaction mixture, detaching the primers, then repeating the cycle using the new and old strands as templates. Since its discovery in 1983, PCR has made possible a number of procedures we now take for granted, such as DNA fingerprinting of crime scenes, paternity testing, and DNA-based diagnosis of hereditary and infectious diseases.
Jul 12, 2006 - 5:22:00 AM
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Latest Research
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Biotechnology
Solitons Could Power Artificial Muscles
Scientists have discovered something new about exotic particles called solitons. Since the 1980s, scientists have known that solitons can carry an electrical charge when traveling through certain organic polymers. A new study now suggests that solitons have intricate internal structures.
Jul 7, 2006 - 6:15:00 PM
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Latest Research
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Biotechnology
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Nanotechnology
Nanoparticles could deliver multi-drug therapy to tumors
In the ongoing search for better ways to target anticancer drugs to kill tumors without making people sick, researchers find that nanoparticles called buckyballs might be used to significantly boost the payload of drugs carried by tumor-targeting antibodies.
Jun 22, 2006 - 5:08:00 PM
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Latest Research
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Biotechnology
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Nanotechnology
Nanotechnology can identify disease at early cellular level
Nanotechnology may one day help physicians detect the very earliest stages of serious diseases like cancer, a new study suggests. It would do so by improving the quality of images produced by one of the most common diagnostic tools used in doctors' offices the ultrasound machine.
Apr 25, 2006 - 9:13:00 PM
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Latest Research
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Biotechnology
Light-sensitive particles change chemistry at the flick of a switch
A light-sensitive, self-assembled monolayer that provides unique control over particle interactions has been developed by scientists at the University of Illinois at Urbana-Champaign. Particles coated with the monolayer change their surface charge and chemistry upon exposure to ultraviolet light.
Mar 27, 2006 - 4:37:00 PM
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Latest Research
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Biotechnology
DNA Fragments for Making Tomatoes Taste Better Identified
Tomatoes are a major nutrient for humans. In 2004, 120,000 tonnes of tomatoes were harvested worldwide - and every year this number increases. Numerous medical studies have shown the health value of tomatoes. Lycopen, the pigment that makes tomatoes red, can for example prevent heart disease. Tomatoes furthermore contain a lot of vitamins C and E, indispensable for human nourishment. But after centuries of cultivation for shape, colour, and other useful qualities, our cultured tomatoes today are of small genetic diversity, in comparison with wild types. This has affected the taste and health value of the fruits.
Mar 27, 2006 - 4:19:00 AM
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Latest Research
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Biotechnology
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Nanotechnology
'Custom' nanoparticles could improve cancer diagnosis and treatment
Researchers have developed "custom" nanoparticles that show promise of providing a more targeted and effective delivery of anticancer drugs than conventional medications or any of the earlier attempts to fight cancer with nanoparticles. Designed at the molecular level to attack specific types of cancer without affecting healthy cells, the nanoparticles also have the potential to reduce side effects associated with chemotherapy, the researchers say. Their study was described today at the 231st national meeting of the American Chemical Society, the worlds largest scientific society.
Mar 27, 2006 - 1:35:00 AM
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Latest Research
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Biotechnology
Human albumin from tobacco plants
Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to stabilise blood volume and to avoid risk of a heart attack, its administration in operating theatres being almost a daily occurrence. It is used for haemorrhages, burns, surgical operations or when the patient shows symptoms of malnutrition or dehydration, chronic infections and renal or liver illnesses. The annual consumption in Spain is about 10 tons but, at a worldwide level, the demand exceeds 500 tons.
Mar 25, 2006 - 3:35:00 PM
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Latest Research
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Biotechnology
A new metal detector to study human disease
Zinc may be a familiar dietary supplement to millions of health-conscious people, but it remains a mystery metal to scientists who study zincs role in Alzheimers disease, stroke and other health problems.
Mar 22, 2006 - 8:07:00 AM
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Latest Research
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Biotechnology
Crucial breakthrough in pectin biosynthesis
Most people know pectin as a common household gelling agent in making jams and jellies, but its uses are vast. It has anticancer properties, for instance, and may have a role in important biological functions including plant growth and development and defense against disease. Despite the importance of pectin as a major component in the primary walls of plants, scientists have known relatively little about how this family of complex polysaccharides is made. Especially perplexing has been how the synthesis of the three different classes of pectic polysaccharides is coordinated to produce the pectin matrix in cell walls.
Mar 22, 2006 - 7:55:00 AM
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Latest Research
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Biotechnology
Enzyme computer could live in human body
Israeli researchers have invented a molecular computer that uses enzymes to perform calculations and could eventually be implanted into the human body and monitor the release of drugs.
Feb 25, 2006 - 10:00:00 AM
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Latest Research
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Biotechnology
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Drug Delivery
Using biologically compatible materials to fabricate a nanoshuttle
Researchers at The University of Texas M. D. Anderson Cancer Center report that they have created a way for viral and gold particles to "directly assemble" and potentially seek out and treat disease where it resides in the body. Their study, published in the online early edition of The Proceedings of the National Academy of Sciences (PNAS) the week of Jan. 23 - 27, 2006, shows the use of biologically compatible materials to fabricate a "nanoshuttle" - thousands of times smaller than a human hair - which can be harnessed to viral particles to precisely home to disease wherever it hides. Once there, the nanoshuttle can perform a variety of functions. The study defines how assembled particles of gold - a metal that is not rejected by the body - could possibly be "tuned" to destroy tissue or emit signals that can be detected by imaging devices. The system also can be adapted to form a flexible scaffold that can carry drugs, genes or even cradle restorative stem cells.
Jan 24, 2006 - 3:51:00 PM
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Latest Research
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Biotechnology
Buckyballs Deform DNA - Surprising Simulation Findings
Soccer-ball-shaped "buckyballs" are the most famous players on the nanoscale field, presenting tantalizing prospects of revolutionizing medicine and the computer industry. Since their discovery in 1985, engineers and scientists have been exploring the properties of these molecules for a wide range of applications and innovations.
Dec 7, 2005 - 7:22:00 PM
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Latest Research
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Biotechnology
ATP Hydrolysis is Required to Reset the ATP-binding Cassette Dimer
Scientists have a tough time visualizing the tiny hatchways that allow nutrients to pass into our cells, but a group of Purdue University biologists may have found the next best thing: a glimpse into the workings of the "motor" that opens and closes them.
Dec 4, 2005 - 9:48:00 AM
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Latest Research
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Biotechnology
First comprehensive map of the proteins and kinase signaling network
A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate, according to a report this week in the journal Nature. The study is a breakthrough in understanding mechanisms of how proteins operate in different cell types under the control of master regulator molecules called protein kinases. Although protein kinases are already important targets of cancer drugs including Gleevec and Herceptin, until recently, it has been difficult to identify the proteins regulated by the kinases.
Dec 1, 2005 - 5:37:00 AM
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Latest Research
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Biotechnology
Magnetic probe successfully tracks implanted cells
By using MRI to detect magnetic probes of tiny iron oxide particles, an international research team for the first time has successfully tracked immune-stimulating cells implanted into cancer patients for treatment purposes.
Nov 21, 2005 - 8:13:00 PM
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Latest Research
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Biotechnology
New Microscope Tracks Functioning Protein at Atomic Level
A Stanford University research team has designed the first microscope sensitive enough to track the real-time motion of a single protein down to the level of its individual atoms. Writing in the Nov. 13 online issue of the journal Nature, the Stanford researchers explain how the new instrument allowed them to settle long-standing scientific debates about the way genes are copied from DNA--a biochemical process that's essential to life. In a second paper published in the Nov. 8 online issue of the journal Physical Review Letters, the scientists offer a detailed description of their novel device, an advanced version of the "optical trap," which uses infrared light to trap and control the forces on a functional protein, allowing researchers to monitor the molecule's every move in real time.
Nov 14, 2005 - 1:49:00 AM
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Latest Research
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Biotechnology
Selenium Speeds Enzymatic Reactions
At the heart of every reaction of every cell lies an enzyme, a protein catalyst. At its active siteâa special pocket on its surfaceâit binds reactants (substrates) and rearranges their chemical bonds, before releasing them as useful products. Rearranging some bonds may require help from certain chemical elements that are present in trace amounts. Many enzymes place these elements at the center of their active sites to do the most critical job.
Nov 8, 2005 - 5:44:00 PM
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Latest Research
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Biotechnology
Exploring Dynamic Personalities of Proteins
A Brandeis University study published in Nature this week advances fundamental understanding of the dynamic personalities of proteins and proposes that these enzymes are much more mobile, or plastic, than previously thought. The research, based on nuclear magnetic resonance (NMR) experiments, may shed new light on how to improve rational drug design through docking to dynamic targets.
Nov 3, 2005 - 4:24:00 PM
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Latest Research
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Biotechnology
Biotech failed to meet promises
Promises of cheaper and better drugs using biotechnologies have not been met, say researchers in this weeks BMJ. They assessed biotech products approved by the European Medicine Evaluation Agency between 1995 and 2003.
Oct 14, 2005 - 9:43:00 PM
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Latest Research
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Biotechnology
Understanding how voltage-gated ion channels operate
One of the biggest mysteries in molecular biology is exactly how ion channels tiny protein pores through which molecules such as calcium and potassium flow in and out of cells operate. Such channels can be extremely important; members of the voltage-gated ion channel family are crucial to generating electrical pulses in the brain and heart, carrying signals in nerves and muscles. When channel function goes awry, the resulting diseases known as channelopathies, including epilepsy, a number of cardiomyopathies and cystic fibrosis can be devastating.
Oct 12, 2005 - 4:56:00 AM
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Latest Research
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Biotechnology
Call for funding boost for robotics research in US
When it comes to developing robots for use in biology and medicine, no country is currently a match for the United States . But that situation could change within the next few years, according to a new report.Unless the government boosts funding for robotics research, the United States the world leader for research and manufacturing of robotic systems for tasks such as surgery and DNA sequencing will likely have to start relying on technology from other countries, said Yuan F. Zheng, professor of electrical and computer engineering at Ohio State.
Sep 20, 2005 - 10:04:00 PM
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Latest Research
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Biotechnology
Biochemistry's future with quantum physics
Chemists who have trouble predicting how some large, complex biological molecules will react with others may soon have a solution from the world of computational quantum physics, say Purdue University researchers.
Sep 19, 2005 - 12:20:00 PM
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Latest Research
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Biotechnology
First comprehensive study of human hair on nanometer level
Ohio State University researchers have just completed the first comprehensive study of human hair on the nanometer level.
Sep 9, 2005 - 5:41:00 PM
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Latest Research
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Biotechnology
Artificial intelligence to help intensive care doctors
A team of systems engineers from the University of Sheffield is developing an intelligent computer system which imitates a doctor's brain to make treatment decisions for intensive care patients. The system will take some of the workload from emergency medical teams by monitoring patients' vital signs and then evaluating and administering the right amounts of different drugs needed - a job usually carried out by specialist medical doctors.
Sep 4, 2005 - 9:27:00 AM
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Latest Research
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Biotechnology
A Global View of DNA-Packing Proteins Cracks the Histone Code
In one of biology's most impressive engineering feats, specialized proteins package some six-and-a-half feet of human DNA into a nucleus that averages just 5 microns (0.0001969 inches) in diameter. In the first of a series of supercondensing steps, DNA winds around proteins called histones, which together form a complex called the nucleosome. Histones package DNA into repetitive coils, which not only provide genomic structure but also help regulate gene expression. These tasks are mediated in part by chemical modifications to histone proteinsmost commonly to histone tails, long, unstructured chains of amino acids that protrude from nucleosomes. Different chemical modifications are associated with different functional effects. Acetylation, which adds an acetyl group to an amino acid on the histone tail, has been linked to both gene activation and silencing, depending on which amino acid is modified. Methylation (addition of a methyl group to the histone tail) has also been linked to gene activation and repression, although the chemical effects of methylation differ dramatically from those of acetylation.
Aug 31, 2005 - 2:12:00 AM
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Latest Research
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Biotechnology
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Drug Delivery
DNA buckyballs for drug delivery created
DNA isn't just for storing genetic codes any more. Since DNA can polymerize -- linking many molecules together into larger structures -- scientists have been using it as a nanoscale building material, constructing geometric shapes and even working mechanical devices.
Aug 29, 2005 - 10:36:00 PM
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Latest Research
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Biotechnology
Method to predict protein separation behavior directly from protein structure
Applying math and computers to the drug discovery process, researchers at Rensselaer Polytechnic Institute have developed a method to predict protein separation behavior directly from protein structure. This new multi-scale protein modeling approach may reduce the time it takes to bring pharmaceuticals to market and may have significant implications for an array of biotechnology applications, including bioprocessing, drug discovery, and proteomics, the study of protein structure and function.
Aug 20, 2005 - 4:38:00 PM
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Latest Research
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Biotechnology
Gene silencing technique can theoretically cure any disease
A new technique aimed at directly controlling the expression of genes by turning them on or off at the DNA level could lead to drugs for the treatment or cure of many diseases, say researchers at UT Southwestern Medical Center.
Aug 11, 2005 - 5:29:00 PM
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Latest Research
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Biotechnology
New role for CIB1 protein as fundamental inhibitor of cell movement
Scientists from the University of North Carolina at Chapel Hill School of Medicine and the UNC Lineberger Comprehensive Cancer Center have identified a protein that may inhibit cellular movement, or migration.
Aug 7, 2005 - 2:35:00 PM
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Latest Research
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Biotechnology
Structure of membrane protein NhaA revealed
The structure of the membrane protein NhaA has been revealed by researchers at the Hebrew University of Jerusalem and the Max Planck Institute of Germany.
Aug 6, 2005 - 11:47:00 AM
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Latest Research
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Biotechnology
Molecule that inhibits regrowth of spinal nerve cells
A molecule that helps the body's motor nerve cells grow along proper paths during embryonic development also plays a major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found.
Jul 14, 2005 - 11:05:00 PM
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Latest Research
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Biotechnology
Aggresome plays a role in thiopurine metabolism
Mayo Clinic researchers have discovered an inherited structural mechanism that can make drugs for some diseases toxic for some patients. The mechanism decreases a protein and in turn causes certain individuals to metabolize thiopurine drugs differently. Thiopurine therapies are used to treat patients with childhood leukemia, autoimmune diseases and organ transplants. The Mayo researchers say their finding advances the field of pharmacogenomics, which tailors medicine to a patient's personal genetic makeup.
Jul 10, 2005 - 4:01:00 PM
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Latest Research
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Biotechnology
Simple Peptides Stabilize Mighty Membrane Proteins
Cell membranes are largely made of proteins, and membrane proteins account for about a third of all genes. Despite their importance, they are devilishly hard to isolate and stabilize, and therefore are hard to study. The problem lies in their structure: membrane proteins have at least one hydrophobic domain, composed of a stretch of water-repelling amino acids, which holds the protein snugly in the lipid membrane. Purifying such a protein in an aqueous medium makes the hydrophobic parts aggregate, destroying the proteins delicate three-dimensional structure and often disrupting its function.
Jun 22, 2005 - 1:05:00 PM
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Latest Research
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Biotechnology
Nano-particle Research to Benefit Inhaler Users
Patients suffering from conditions as diverse as asthma and diabetes could benefit from research at Cardiff University to improve the effectiveness of drugs taken through spray inhalers.
May 1, 2005 - 9:10:00 PM
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Latest Research
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Biotechnology
Engineer turns Bacteria into Living Computers
In a step toward making living cells function as if they were tiny computers, engineers at Princeton have programmed bacteria to communicate with each other and produce color-coded patterns.
Apr 28, 2005 - 12:13:00 AM
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Latest Research
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Biotechnology
Structural Insights into a Porphyrin-Binding Protein
Eukaryotic cells have an organizational problem. The specialized proteins found in cellular organelles (structures with specific functions such as energy production) are mostly encoded within the nucleus. To build and maintain a cell that works efficiently under all conditions, each type of organelle needs to be able to send signals to the nucleus to say Send more protein X or hold back on enzyme Y. Think of it as the cellular version of grocery store clerks restocking orders to the warehouse.
Apr 27, 2005 - 2:27:00 AM
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Latest Research
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Biotechnology
Domain protecting proteins from degradation identified
The first stabilizing signal that protects a protein from degradation has been identified.
Apr 18, 2005 - 9:37:00 PM
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Latest Research
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Biotechnology
At the molecular level, the predator is the prey
An evolutionary arms race between predatory garter snakes and their newt quarry is turning out to be something of an illusion. At the molecular level, another battle rages. Biologists at Indiana University Bloomington, Utah State University and the University of Utah present evidence in this week's Nature that a toxin produced by the rough skinned newt, Taricha granulosa, has forced several evolutionary changes in the garter snake Thamnophis sirtalis or, more specifically, in the snake nerve cell protein that endures the toxin's attacks.
Apr 14, 2005 - 4:01:00 PM
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Latest Research
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Biotechnology
Simplicity of Histone Code Revealed
Histones, which package DNA in eukaryotes, play an important role in gene regulation. According to the histone code hypothesis, covalent posttranslational modification of histone tails, in this case, acetylation, influences gene regulation by altering transcriptional output.
Mar 30, 2005 - 6:45:00 AM
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Latest Research
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Biotechnology
Dynamic, Artificial Cells and Vesicles
Scott Long et al. have constructed synthetic cells comprised of lipid bilayer membranes surrounding a two-phase, aqueous polymer solution that can be reversibly converted to a single phase. An understanding of compartmentalization in cell function has been hampered by the lack of an experimental model system.
Mar 30, 2005 - 6:45:00 AM
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Latest Research
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Biotechnology
Bmpr1a and Bmpr1b Essential for Cartilage Formation
Larger brains are hypothesized to have evolved as an adaptation to cope with novel or changed environments, yet empirical support has been difficult to find.
Mar 30, 2005 - 6:45:00 AM
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Latest Research
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Biotechnology
Triterpenoids Protect Against Oxidative and Electrophile Stress
Albena Dinkova-Kostova et al. report that synthetic triterpenoid (TP) analogs of oleanolic acid can activate the phase 2 response, which protects cells against electrophile and oxidant toxicities and blocks the inflammatory response to IFN-γ.
Mar 30, 2005 - 6:45:00 AM
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Latest Research
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Biotechnology
Triterpenoids Protect Against Oxidative and Electrophile Stress
Albena Dinkova-Kostova et al. report that synthetic triterpenoid (TP) analogs of oleanolic acid can activate the phase 2 response, which protects cells against electrophile and oxidant toxicities and blocks the inflammatory response to IFN-γ.
Mar 29, 2005 - 5:50:00 PM
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Latest Research
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Biotechnology
Unique Mutant Leptin Protein Developed
A unique technique for neutralizing the action of the leptin protein in humans and animals thereby providing a means for controlling and better understanding of leptin function, including its role in unwanted cell growth -- has been developed.
Mar 18, 2005 - 10:27:00 PM
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Latest Research
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Biotechnology
Gene Therapy to Restore Hair Cells in Deaf
Researchers supported by the National Institute on Deafness and Other Communication Disorders successfully used gene therapy to grow new hair cells and restore hearing in deaf guinea pigs. This is the first time researchers have been able to restore structural and functional levels to auditory hair cells in live adult mammals.
Mar 1, 2005 - 5:51:00 PM
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Latest Research
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Biotechnology
Wnt10b signalling protein protects against bone loss from aging or lack of estrogen
To study the effect of Wnt10b gene expression on tissue development, MacDougald's research team created an artificial sequence of DNA called a transgene linking Wnt10b to the FABP4 promoter, which is expressed in fatty tissue and in bone marrow. U-M scientists injected the transgene DNA into fertilized mouse eggs, and then bred mice that inherited the new gene to create the transgenic animals used in their research.
Feb 22, 2005 - 6:17:00 PM
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