By American Society of Nephrology, [RxPG] The corelation between leptin, PTH and bone density in Chronic kidney disease has been examined in many studies in the past. A study published in the December issue of Clinical Journal of the American Society of Nephrology looked at the effect of adipose tissue on bone turnover through leptin production in kidney transplant recipients.
The study analysed associations of serum leptin with PTH and with biomarkers of bone turnover, viz. serum beta crosslaps (a marker of bone resorption) and osteocalcin (a marker of bone formation) in 978 kidney transplant recipients.
Higher leptin levels were associated with higher PTH and lower vitamin D levels, but on further analysis it was found that the effect of leptin on PTH was mediated through Vitamin D. High leptin levels were found to be significantly associated with lower levels of the bone turnover markers. The authors therefore concluded that elevated leptin level is independantly associated with lower bone turnover in kidney transplant recipients.
Publication:
December issue of Clinical Journal of the American Society of Nephrology
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This news story has been reviewed by Dr. Sanjukta Acharya before its publication on RxPG News website. Dr. Sanjukta Acharya, MBBS MRCP is the chief editor for RxPG News website. She oversees all the medical news submissions and manages the medicine section of the website. She has a special interest in nephrology. She can be reached for corrections and feedback at [email protected]
RxPG News is committed to promotion and implementation of Evidence Based Medical Journalism in all channels of mass media including internet.
Additional information about the news article
Associations between Serum Leptin Level and Bone Turnover in Kidney Transplant Recipients Csaba P. Kovesdy, Miklos Z. Molnar, Maria E. Czir, Anna Ruda, Akos Ujszasz, Laszlo Rosivall, Miklos Szathmari, Adrian Covic, Andras Keszei, Gabriella Beko, Peter Lakatos, Janos Kosa, Istvan Mucsi
CJASN December 2010 5): (12) 2297-2304
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