Blood vessel regeneration possible in adult hearts
Nov 19, 2006 - 7:27:40 AM
, Reviewed by: Priya Saxena
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"TB4 is presented here as a single factor that can potentially couple myocardial [heart] and coronary vascular regeneration in failing mouse hearts,"
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By RegeneRx,
[RxPG] REGENERX BIOPHARMACEUTICALS, INC. reported today that a study published in the advanced online edition of the journal Nature supported and elaborated TB4's significant effects in the damaged hearts of mice and highlighted its therapeutic potential for the treatment of heart attacks and heart failure in humans.
"TB4 is presented here as a single factor that can potentially couple myocardial [heart] and coronary vascular regeneration in failing mouse hearts," according to researchers from the University College London's Institute of Child Health, London, UK; Baylor College of Medicine, Houston, TX; Massachusetts General Cardiovascular Research Center, Boston, MA; and Harvard Medical School and Harvard Stem Cell Institute, Cambridge, MA.
"A major shortcoming of current angiogenic therapy in response to myocardial ischemia in humans is that the outcome may be limited to capillary growth without concomitant collateral support of arterioles [terminal branches of arteries]. Our findings that, in mice, TB4 can promote vessel formation and collateral growth not only during development but also critically from adult epicardium, suggest TB4 has considerable therapeutic potential in humans," stated the researchers.
"These results are very exciting because most humans suffering from ischemic cardiac events, either acutely or chronically, do not develop the collateral vessel growth necessary to preserve and restore heart tissue. If, in humans, we see the same effects as seen in mice, TB4 would be the first drug to prevent loss of [heart] muscle cells and restore blood flow in this manner and provide a new and much needed treatment modality for these patients," commented Deepak Srivastava, M.D., Professor and Director, Gladstone Institute of Cardiovascular Disease, University of California San Francisco, CA. Dr. Srivastava and his colleagues published the first paper on TB4's effects on myocardial infarction in Nature in November 2004.
The study was funded by the British Heart Foundation and the Medical Research Council.
Over 105,000 people die from heart disease in the UK each year. Heart attacks occur in over one million people annually in the United States and over thirteen million suffer from coronary artery disease, making it the single largest cause of death in the Western world.
Publication:
Advanced online edition of the journal Nature
On the web:
www.regenerx.com 
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| Funding information and declaration of competing interests:
The study was funded by the British Heart Foundation and the Medical Research Council.
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Additional information about the news article
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The RegeneRx Technology Platform
Thymosin beta 4 (TB4) is a synthetic version of a naturally occurring peptide present in virtually all human cells. It is a first-in-class drug candidate that promotes endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition, and down-regulates inflammation. One of TB4's key mechanisms of action is its ability to regulate the cell-building protein, actin, a vital component of cell structure and movement. Of the thousands of proteins in cells, actin represents up to 10% of the total protein and, thus, plays a major role in the physiology of the cell. RegeneRx has identified several molecular variations of TB4 that may affect the aging of skin, among other properties, and could be important candidates as active ingredients in pharmaceutical and consumer products.
Researchers at the National Institutes of Health, and at other academic institutions throughout the U.S., have published numerous scientific articles indicating that TB4 is effective in accelerating dermal and corneal wound healing in several animal models, under a variety of conditions. In two articles published in the scientific journal, Nature, researchers found that TB4 protects heart tissue following a myocardial infarction (heart attack) and can regenerate coronary vessels in laboratory animals. Abstracts of scientific papers related to TB4's mechanisms of action may be viewed at RegeneRx's web page: www.regenerx.com.
About RegeneRx Biopharmaceuticals, Inc.
RegeneRx is focused on the discovery and development of novel molecules to accelerate tissue and organ repair. Currently, RegeneRx is developing TB4, a 43 amino acid peptide, in part, under an exclusive world-wide license from the National Institutes of Health. Preliminary research suggests that TB4 may prove efficacious for multiple indications; therefore, RegeneRx is developing TB4 as a therapeutic platform. RegeneRx holds nearly 60 world-wide patents and patent applications related to dermal, ocular, and internal wounds and tissue repair, cardiac and neurological injuries, and septic shock. RegeneRx is currently sponsoring three Phase II chronic dermal wound healing clinical trials and has additionally targeted ophthalmic and cardiac trials in 2007 as part of its ongoing clinical development program.
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