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Last Updated: Oct 11, 2012 - 10:22:56 PM
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Eating less may help you live longer

Dec 29, 2009 - 3:05:57 PM , Reviewed by: Dr. Rashmi Yadav
They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under the same conditions, said a UAB release.

Main results
Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. On analysis of normal WI-38 and immortalized WI-38/S fetal lung fibroblasts in this study, it was found that glucose restriction resulted in growth inhibition and apoptosis in WI-38/S cells, whereas it induced lifespan extension in WI-38 cells. Moreover, in WI-38/S cells glucose restriction decreased expression of hTERT (human telomerase reverse transcriptase) and increased expression of p16INK4a. Opposite effects were found in the gene expression of hTERT and p16 in WI-38 cells in response to glucose restriction. The altered gene expression was partly due to glucose restriction-induced DNA methylation changes and chromatin remodeling of the hTERT and p16 promoters in normal and immortalized WI-38 cells. Furthermore, glucose restriction resulted in altered hTERT and p16 expression in response to epigenetic regulators in WI-38 rather than WI-38/S cells, suggesting that energy stress-induced differential epigenetic regulation may lead to different cellular fates in normal and precancerous cells. Collectively, these results provide new insights into the epigenetic mechanisms of a nutrient control strategy that may contribute to cancer therapy as well as antiaging approaches.
[RxPG] Going back for a second dessert after your holiday meal might not be the best strategy for living a long, cancer-free life, a new study has confirmed.

University of Alabama-Birmingham - researchers have shown exactly how restricted calorie diets, specifically in the form of restricted glucose -, help human cells live longer.

This discovery could help lead to drugs and treatments that slow human ageing and prevent cancer.

'Our hope is that the discovery that reduced calories extend the lifespan of normal human cells will lead to further discoveries of the causes for these effects in different cell types...,' said Trygve Tollefsbol, researcher at the Centre for Aging and Comprehensive Cancer Centre UAB.

'We would also hope for these studies to lead to improved prevention of cancer as well as many other age-related diseases through controlling calorie intake of specific cell types,' he added.

Tollefsbol and colleagues used normal human lung cells and pre-cancerous human lung cells that were at the beginning stages of cancer formation.
Eating less may help you live longer
Eating less may help you live longer

Both sets of cells were lab grown and received either normal or reduced levels of glucose. As the cells grew over a period of a few weeks, researchers monitored their ability to divide, and tracked how many cells survived over this period.

They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under the same conditions, said a UAB release.

'Western science is on the cusp of developing a pharmaceutical fountain of youth,' said Gerald Weissmann, medical expert and editor-in-chief of the Federation of American Societies for Experimental Biology - Journal, which published these findings.

Original research article: http://www.fasebj.org/cgi/rapidpdf/fj.09-149328v1 
DOI of the scientific paper: doi:10.1096/fj.09-149328 
Publication: Yuanyuan Li, Liang Liu, and Trygve O. Tollefsbol; Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression; FASEB J. first published on December 17, 2009 
On the web: The Federation of American Societies for Experimental Biology. 

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 About Dr. Rashmi Yadav
This news story has been reviewed by Dr. Rashmi Yadav before its publication on RxPG News website. Dr. Rashmi Yadav, MBBS, is a senior editor for RxPG News. In her position she is responsible for managing special correspondents and the surgery section of the website. Her areas of special interest include cardiothoracic surgery and interventional radiology. She can be reached for corrections and feedback at [email protected]
RxPG News is committed to promotion and implementation of Evidence Based Medical Journalism in all channels of mass media including internet.
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

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