Inhibiting NF kappa B protects against Liver Injury
Mar 18, 2005 - 11:06:00 PM
The researchers found that inhibiting NF kappa B protects against liver injury by decreasing expression of inflammatory proteins and may be a therapeutic target in liver disease.
By Journal of Clinical Investigation, [RxPG] Liver damage after organ transplantation or hemorrhagic shock is due to a type of injury known as ischemia/reperfusion, occurring when blood flow is temporarily stopped and, upon restoration, leads to massive inflammation and death of liver cells.
Studies have shown that a protein called NF kappa B plays a role in this type of injury, but its precise function is unclear. In a study appearing online on March 17, in advance of the April 1 print edition of the Journal of Clinical Investigation, Christian Trautwein and colleagues from Hannover Medical School interfere with NF kappa B function in liver cells to examine its role in liver injury.
The researchers found that inhibiting NF kappa B protects against liver injury by decreasing expression of inflammatory proteins and may be a therapeutic target in liver disease.
Publication:
TITLE: Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis, but protects from ischemia/reperfusion-injury; April 1 print edition of the Journal of Clinical Investigation
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