RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
 Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Research Article
Latest Research Channel

subscribe to Latest Research newsletter
Latest Research

   EMAIL   |   PRINT
Newly approved ocular safety methods reduce animal testing

Jun 23, 2008 - 4:00:00 AM
The ICCVAM Test Method Evaluation Report: In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication 06-4511) contains the ICCVAM recommendations for these two alternative eye test methods and how results can be used to determine appropriate warning labels and special packaging requirements. The report also includes proposals for new studies that might further increase the usefulness of alternative test methods for detecting products that cause severe eye damage.

 
[RxPG] Federal regulatory agencies have accepted recommendations of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) for two methods that can reduce live animal use for ocular safety testing, the committee announced today. ICCVAM is a permanent interagency committee composed of representatives from 15 federal regulatory and research agencies, including the National Institutes of Health (NIH) that use, generate or disseminate toxicology testing information.

The two alternative test methods, the bovine corneal opacity and permeability (BCOP) assay and the isolated chicken eye (ICE) assay, do not involve the use of live animals. These are the first scientifically valid alternative methods to gain regulatory acceptance for ocular safety testing.

The Consumer Product Safety Commission (CPSC), the Environmental Protection Agency (EPA), and the Food and Drug Administration (FDA) concurred with the ICCVAM recommendations for the BCOP and ICE tests. CPSC will now accept these tests instead of the conventional ocular toxicity test for the purpose of classification for labeling under the Federal Hazardous Substance Act (15 U.S.C. 1261-1278).

Based on an extensive database of product test results, the use of these two alternative test methods will likely reduce the use of live animals for eye safety testing by 10 percent or more, stated William Stokes, D.V.M., the executive director of ICCVAM and director of the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods NICEATM). More importantly, the use of these tests will eliminate the testing in animals of most substances likely to cause the most severe pain and discomfort.

If a positive response is obtained using either of the two new approved alternative methods, the product can be labeled as causing irreversible or severe eye damage and no live animal testing will be required. If the response is negative, the product is then tested in an animal to confirm that it does not cause severe or irreversible damage.

The NIH and other federal agencies are committed to the welfare of animals used in research. All animals used in federally funded research are protected by laws, regulations and policies to ensure they are used in the smallest number possible and with the greatest commitment to their comfort. ICCVAM is working to promote the development and validation of alternative test methods. Alternative test methods are those that accomplish one or more of the 3Rs of reducing the number of animals used in testing, or refining procedures so animals experience less pain and distress, or replacing animals with non-animal systems.

Marilyn Wind, Ph.D., chair of ICCVAM and principal ICCVAM representative for the CPSC said, The use of these alternative methods will help reduce animal use while ensuring the proper identification and hazard labeling for substances that may cause severe or permanent eye damage.

Before certain new products such as drugs and pesticides can be marketed in the United States, they must be tested for their potential to adversely affect the health of consumers. Currently, the FDA, the CPSC and the EPA require that these and other products such as cosmetics, shampoos, detergents and household chemical products be labeled with information on hazards for human health. Tests that use animals are among the tests used by these federal agencies to evaluate potential damage to the eye that may result from exposure to these products. ICCVAM conducted a comprehensive scientific review of four alternative test methods and concluded that the BCOP and ICE methods can be useful for identifying products that may cause permanent or severe damage to an exposed eye. ICCVAM's evaluation report and recommendations were forwarded to federal agencies for their consideration in October 2007.

The ICCVAM Test Method Evaluation Report: In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication 06-4511) contains the ICCVAM recommendations for these two alternative eye test methods and how results can be used to determine appropriate warning labels and special packaging requirements. The report also includes proposals for new studies that might further increase the usefulness of alternative test methods for detecting products that cause severe eye damage.

ICCVAM's recommendations were made after consideration of public comments and a report from an independent scientific peer review panel. The full report is available at the ICCVAM-NICEATM Web site (




Advertise in this space for $10 per month. Contact us today.


Related Latest Research News


Subscribe to Latest Research Newsletter

Enter your email address:


 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)