RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
 Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Research Article
Latest Research Channel

subscribe to Latest Research newsletter
Latest Research

   EMAIL   |   PRINT
Research suggests new options in treating skin pigment problems

Aug 22, 2007 - 4:00:00 AM
“Surprisingly,” he adds, “intermediate skin color was obtained when melanocytes and keratinocytes were combined from light and dark skin together.”

 
[RxPG] Melanocytes are not the only cells responsible for differences in skin coloration. New research from the University of Cincinnati (UC) has shown that some of the most basic cells on the skin’s surface influence pigment production and help regulate skin coloration.

The finding offers hope for new approaches to the treatment of pigmentation disorders that leave the skin disfigured by light or dark blotches.

In a two-year, preclinical dermatological study, Raymond Boissy, PhD, and his team found that cells known as keratinocytes express certain characteristics that could control skin pigmentation.

Keratinocytes are surface skin cells that make up about 96 percent of the skin’s outer layer (epidermis). The cells give the skin structural integrity and protect the body from infection.

Melanocytes, the body’s melanin-producing cells, make up another 2 percent of the epidermis. Melanin is the chemical responsible for skin pigmentation or color.

Boissy says his team’s findings could help scientists develop new drugs that alter the physiological processes that cause pigmentation disorders such as vitiligo—white blotches that occur near the body’s orifices and joints—and melasma, a disorder characterized by dark pigmented lesions.

“We’ve isolated specific physiological properties that regulate the melanocytes’ functional abilities,” explains Boissy, UC professor of dermatology and principal investigator for the study. “This is an important discovery because many pigment diseases are the result of deregulation of the melanocyte.”

“Now we have a new set of molecules to investigate that may help create uniform skin color—both for patients with pigment disorders or serious burn wounds as well as those seeking improved cosmetic skin appearance,” he adds.

The UC-led study, published in the September issue of The FASEB Journal, is the first to identify a specific model for manipulating melanin production in the body by using keratinocytes.

Previous research has shown that keratinocytes receive “packages” of pigment granules (melanosomes) from melanocytes. In dark-skinned people, these packages are dispersed throughout the cell individually, creating a larger surface area that absorbs more light than skin cells of light-skinned people, which disperse pigment in clusters.

“This was the first clue that keratinocytes played a role in skin coloration outside of genetic factors regulating the melanocyte,” says Boissy. “Further study showed there was no informational difference between the melanosomes in keratinocytes for dark and light skin responsible for sorting within the keratinocyte. The cells sorted themselves based on ethnic background, so we wanted to learn more about the factors that influence skin pigmentation.”

For this study, Boissy and his team developed a human skin substitute model using a combination of keratinocytes and melanocytes derived from donated light and dark skin. These mixed cells were transplanted into a mouse model and allowed to grow into the skin substitute for about three months.

“We found that by transplanting keratinocytes from light-skinned individuals to bioengineered skin substitutes produced a lightening effect,” says Boissy. “The same effect resulted when keratinocytes from dark-skinned individuals were transplanted into the skin substitute, creating a darkening effect.

“Surprisingly,” he adds, “intermediate skin color was obtained when melanocytes and keratinocytes were combined from light and dark skin together.”

In addition, the researchers discovered that the keratinocytes also influenced how much pigment is actually produced. Boissy says the effect is subtle, but it shows that it’s not just genetics of the melanocyte that determines skin coloration.




Publication: FASEB Journal

Funding information and declaration of competing interests: Kao Biological Sciences Laboratories

Advertise in this space for $10 per month. Contact us today.


Related Latest Research News


Subscribe to Latest Research Newsletter

Enter your email address:


 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)