RxPG News Feed for RxPG News

Medical Research Health Special Topics World
 Asian Health
 Food & Nutrition
 Men's Health
 Mental Health
 Occupational Health
 Public Health
 Sleep Hygiene
 Women's Health
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 World Healthcare
   Latest Research
 Alternative Medicine
 Clinical Trials
 Infectious Diseases
  Anorexia Nervosa
  Child Psychiatry
  Forensic Psychiatry
  Mood Disorders
  Peri-Natal Psychiatry
  Personality Disorders
  Sleep Disorders
   Circardian Rhythm
  Substance Abuse
 Sports Medicine
   Medical News
 Awards & Prizes
   Special Topics
 Odd Medical News

Last Updated: Oct 11, 2012 - 10:22:56 PM
Sleep Disorders Channel

subscribe to Sleep Disorders newsletter
Latest Research : Psychiatry : Sleep Disorders

   EMAIL   |   PRINT
New sleep gene discovery wakes up scientists

Jul 4, 2006 - 9:51:00 PM , Reviewed by: Ankush Vidyarthi
"The theory was that the mutation caused (more of the PERIOD protein) so you get a short day so you want to get up very early in the morning"

[RxPG] Proteins that regulate sleep and biological timing in the body work much differently than previously thought, meaning drug makers must change their approach to making drugs for sleep disorders and depression and other timing-related illnesses.

The surprise finding is an about-face from previous research, said Daniel Forger, assistant professor of math at the University of Michigan. Forger and his collaborators from the University of Utah's Huntsman Cancer Institute have written a paper on the topic, which will appear on in the July 11 issue of the Proceedings of the National Academy of Science.

Scientists studied two proteins (one called CKIe and another called PERIOD) that help regulate timing in the body, and looked at how those proteins function in cells, said Forger. One of the proteins causes the other protein to degrade, and the body knows what time it is by how much or how little PERIOD protein is present at any one time in the body. The body's clock is called a circadian rhythm.

Drug makers spend billions to develop drugs to help people with sleep disorders, and other disorders impacted by our biological clocks. Drugs to restore a healthy circadian rhythm by manipulating the levels of PERIOD proteins are currently under development.

One such sleep disorder is called Familial Advanced Sleep Phase Syndrome and this is caused by a gene mutation, Forger said. Patients suffering from the disease routinely wake very early, say at 4 a.m. and must go to bed early, at say 7 p.m. said Forger.

If put in a cave with no light, these people should have a shortened day, Forger said. This means that on our time, they would wake the first day at say, 6 a.m. then at 4 a.m. then at 2 a.m. on subsequent days.

"When they have light and dark cycles in the normal world, they pretty much have to live in a 24-hour day," Forger said. "They were able to adjust but the price they have to pay is their body wakes up early, and they have to go to bed earlier than we do."

"The theory was that the mutation caused (more of the PERIOD protein) so you get a short day so you want to get up very early in the morning," Forger said. But, during testing they found the opposite is true: the mutation actually caused the PERIOD to degrade more quickly so that less is present in the body.

The finding wasn't a complete surprise to Forger, who develops math models of the circadian rhythms. Forger's computer models always said that the opposite of the prevailing thinking should be true---that the PERIOD protein should degrade more quickly when the mutation is present.

"I had this prediction for a year or two," Forger said. "Basically, people said this is ridiculous, you're a mathematician, what do you know…"

Then he met David Virshup, M.D., while giving an invited talk at the University of Utah. Virshup's previous research was on the gene involved in circadian rhythms and its role in cancer development. Their experiments had also suggested that genetic mutation caused the protein to degrade more quickly. Virshup suggested they test Forger's simulation.

The researchers took cell cultures and observed that for those with the mutated gene, the protein only took a couple hours to degrade. For the normal gene, it took 8-10 hours.

Next, Virshup said, his team will begin testing ways to regulate the circadian rhythm in mice, a necessary step before new drugs can be developed.

Publication: July 11 issue of the Proceedings of the National Academy of Science
On the web: www.pnas.org/cgi/doi/10.1073/pnas.0604511103 

Advertise in this space for $10 per month. Contact us today.

Related Sleep Disorders News
Sleep loss can cause testosterone levels to plummet
Snoring due to sleep apnea can damage brain severely
Meditation may be effective for treating insomnia
Caffeine may prevent risk taking after sleep deprivation
Surgical weight loss does not eliminate sleep apnea
Sleep disturbances among the elderly linked to suicide
Slow wave activity during sleep is lower in African-Americans
Reduced sleep quality can aggravate psychological conditions
Imagery rehearsal therapy improves sleep
Extended Shifts for Medical Interns Negatively Impact Patient Safety

Subscribe to Sleep Disorders Newsletter

Enter your email address:

 Additional information about the news article
Funding for the study was provided by the National Institutes of health, the Huntsman Cancer Institute and the Sloan Foundation.
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

Contact us

RxPG Online



    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)