XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
 Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate
Search

Last Updated: Nov 18, 2006 - 1:55:25 PM
Systematic Review

Special Topics Channel
subscribe to Special Topics newsletter

Special Topics

   DISCUSS   |   EMAIL   |   PRINT
Drug Company Research Reports Should Be Read With Caution
Oct 12, 2006 - 1:19:00 PM, Reviewed by: Dr. Venkat Yelamanchili

Cochrane reviews compared with industry-supported meta-analyses and other meta-analyses of the same drugs: systematic review

 
A study published on bmj.com recently has found that reviews of drugs which are supported by the pharmaceutical industry are less transparent, and are more likely to reach favourable conclusion on drugs, than independent reviews.

According to the authors, bias in drug trials is common and often favours the trial-sponsor’s product. To balance this effect, independent reviews – which can have a more critical and systematic approach - are essential to ensure doctors and other health professionals have the information they need on drugs.

The authors, based in Denmark, compared the results of 24 pairs of reviews conducted by different people on the same drugs. Compared to reviews supported by the pharmaceutical industry, reviews undertaken by the Cochrane Collaboration – an independent body – were of a higher quality and were more likely to address the potential for bias in the review.

Of seven industry-supported reviews, all recommended the experimental drug without reservation, whilst none of the corresponding Cochrane reviews reached the same conclusion. Six of the eight Cochrane reviews analysed had reservations about the quality or relevance of the trials or their findings and two of them noted that the effect decreased with increasing number of patients in the trial. Seven mentioned higher cost of the experimental drug as a problem. In contrast, none of the industry-supported reviews mentioned higher cost as a problem, and two claimed that the experimental drug was cost-effective.

The researchers also found that the reviews with not-for-profit support or no support had similarly cautious conclusions as the Cochrane reviews.

The authors conclude that industry-supported reviews should be read with caution. They also want greater transparency, including the inclusion of more information on methodology and the estimated effects of the drugs, in order to allow readers to judge the reliability of drug reviews.
 

- British Medical Journal, 7 October 2006 (Vol 333, No 7571)
 

Read the full text original research article at BMJ website

 
Subscribe to Special Topics Newsletter
E-mail Address:

 



Related Special Topics News
MPs express anguish at Delhi gang-rape, Shinde assures fast trial
Worrying rise in number of medical students in prostitution over last 10 years
Behold India's unfolding democratic revolution
Chinese woman cuts open her belly to save surgery cost
Improved Sense of Smell Produced Smarter Mammals
Two-year-old world's first to have extra DNA strand
172,155 kidney stones removed from one patient!
'Primodial Soup' theory for origin of life rejected in paper
Human species could have killed Neanderthal man
History, geography also seem to shape our genome


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us